Antidepressant-like effect of the extract from leaves of Schinus molle L. in mice: Evidence for the involvement of the monoaminergic system

Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system

“…1b). The doses of the antagonists and the administration schedule used in these experiments were chosen on the basis of experiments previously performed (Savegnago et al 2007;Brüning et al 2008) and the literature data confirm the selectivity and efficacy of the abovementioned treatments at the doses used (O'Neill and Conway 2001;Bourin et al 2009;Machado et al 2007;Posser et al 2009). …”

A review on antidepressant effect of medicinal plants

“…molle, from family Anacardiaceae, is native to South America but has been introduced to most tropical and subtropical regions across the world. This plant has been reported to exert certain pharmacological properties including anti-inflammatory, antitumor, antifungal, anticonvulsant, and analgesic (Machado et al, 2007). Injection with n-hexane S. molle extract (3-600 mg/kg) significantly decreased the immobility duration in tail suspension test in mice with an efficacy comparable to that of fluoxetine (10 mg/kg).…”

Evaluation of behavioral and pharmacological effects of Hedyosmum brasiliense and isolated sesquiterpene lactones in rodents

“…To address some of the mechanisms by which the extract EEHb causes anxiolytic-like action in the plus-maze test, animals were treated with different drugs. The doses of drugs used were selected on the basis of literature data and on previous results from our laboratory (De-Souza et al, 2003;Aragão et al, 2006;Machado et al, 2007).…”