Antidepressant-like effects of saringosterol, a sterol from Sargassum fusiforme by performing in vivo behavioral tests

Jin, Hong-Guo; Zhou, Min; Jin, Qinghao; Liu, Bingyu; Guan, Liping

doi:10.1007/s00044-017-1804-2

Cited by 9 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The physiological functions of C4-SBIs were investigated using the elegant virus-induced gene silencing strategy (VIGS) in Nicotiana benthamiana, as already established in the case of the C14-demethylation step (CYP51; [124]). VIGS of SMO1 and SMO2 indicated deficiencies in distinct entities based on distinct sterol profiles: SMO1-silenced plants exhibited 4,4-dimethyl-9β,19-cyclopropylsterols as major sterols whereas SMO2-silenced plants had 4α-methyl-∆ 7 -sterols [117].…”

Section: The Plant-specific Sterol-c4-demethylation Process and Its I...mentioning

confidence: 99%

Chemical Biology of Sterols, Triterpenoids and Other Natural Products

2019

View full text Add to dashboard Cite

Wenxu Zhou studies sterol metabolism and regulations of a variety of organisms including higher plants, marine algae, pathogenic fungi, parasitic protozoa, and animals. His research focuses on identifying the unique niches of sterol metabolism among different organisms and utilizing them for new chemotherapeutic targets and new strategies for plant pest control. He has extensive experience in natural product chemistry, chromatography technologies, GC/MS base metabolomics,

show abstract

Section: The Plant-specific Sterol-c4-demethylation Process and Its I...mentioning

confidence: 99%

Chemical Biology of Sterols, Triterpenoids and Other Natural Products

2019

View full text Add to dashboard Cite

show abstract

“…Sargassum fusiforme is a kind of brown edible algae that is widely distributed on the seashores of China, Korea, and Japan as a therapeutic for thousands of years [ 21 ]. Saringosterol, a phytosterol extracted from Sargassum fusiforme , has been shown to exhibit anti-tubercular activity by inhibiting the growth of Mycobacterium tuberculosis [ 22 ], as well as antidepressant-like effects [ 23 ], anti-obesity activity [ 24 ], and the effect of preventing cognitive decline [ 25 ]. Furthermore, we previously demonstrated that saringosterol has a potent and selective action for LXRβ in vitro, and is a potentially natural cholesterol-lowering agent [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Saringosterol from Sargassum fusiforme Modulates Cholesterol Metabolism and Alleviates Atherosclerosis in ApoE-Deficient Mice

et al. 2021

View full text Add to dashboard Cite

Dysregulation of cholesterol homeostasis is a major risk factor of atherosclerosis, which can lead to serious health problems, including heart attack and stroke. Liver X receptor (LXR) α and β are transcription factors belonging to the nuclear receptor superfamily, which play important roles in cholesterol homeostasis. Selectively activating LXRβ provides a promising strategy for the treatment of atherosclerosis. Here, we employed atherosclerotic apoE-knockout mice to evaluate the effects of saringosterol, a phytosterol with potent and selective action for LXRβ, which we identified previously in edible marine seaweed Sargassum fusiforme. We found that saringosterol treatment reduced the atherosclerotic plaque burden without having undesirable adverse hepatic effects in apoE-deficient mice fed an atherogenic diet. Meanwhile, reduced serum levels of cholesterol, accompanied by altered expression of LXR-regulated genes involved in cholesterol absorption, transport, efflux, excretion, and elimination, were observed in apoE-knockout mice after saringosterol treatment. Together, our study not only establishes saringosterol as an effective cholesterol-lowering and anti-atherogenic phytosterol but also provides insights into the underlying mechanism.

show abstract