Antidiabetic activity of Boerhaavia diffusa L.: effect on hepatic key enzymes in experimental diabetes

Pari, Leelavinothan; Satheesh, M. Amarnath

doi:10.1016/j.jep.2003.12.013

Cited by 167 publications

(108 citation statements)

References 22 publications

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“…In Ayurvedic and Unani, the miracle medicinal plant finds to use as a cure for 22 ailments. In Brazilian pharmacopeia, 23 uses have been described for the plant, while in Africa and Middle East, the plant is prescribed for 14 ailments [1] .…”

Section: Introductionmentioning

confidence: 99%

“…Pharmacological studies have demonstrated that B. diffusa known to possess anticonvulsant [4] , diuretic, anti-inflammatory, antifibrinolytic [9] , antibacterial [10] , anti-hepatotoxic, anthelmintic, febrifuge, anti-leprosy, antiasthmatic, antiurethritis, antilymphoproliferative [11] , antimetastatic [12] , immunosuppressive [13] , antidiabetic, antioxidant [14] , immune-modulation [15] , hepatoprotective [16] , anti-nociceptive, nephroprotective [17] , bacteria induced ulcer & diarrhea [18] and antiurolithiatic [19] activities. The identification of phytoconstituents and assay of antioxidant, thrombolytic, cytotoxic, antimicrobial activities were conducted using specific standard in vitro procedures.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phytochemical screening and in vitro bioactivities of the extracts of aerial part of Boerhavia diffusa Linn.

Apu

Liza

Jamaluddin

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical screening and in vitro bioactivities of the extracts of aerial part of Boerhavia diffusa Linn.

Apu

Liza

Jamaluddin

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…This suggested that the plant protects against hepatic injury in rats (Rawat et al, 2008). The anti-diabetic property of B. diffusa leaf extract was also studied in normal and alloxan induced diabetic rats and found to significantly decrease blood glucose and significantly increase plasma insulin levels (Pari et al, 2008). This was thought to be due to rapid phosphorylation of glucose by hexokinase causing increased utilization of glucose for energy production.…”

Section: Introductionmentioning

confidence: 98%

“…Traditionally, the plant has been evaluated for its hepatoprotective, anti-diabetic, diuretic, anti-inflammatory, antibacterial, antiviral and cancer chemopreventive properties (Rawat et al, 2008;Pari et al, 2008). In rats, aqueous extract of thinner roots of B. diffusa at a dose of 2 ml/kg caused a reduction in the levels of serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase when compared with control rats.…”

Section: Introductionmentioning

confidence: 99%

The effect of the aqueous extract of the leaves of <i>Boerhavia diffusa</i> Linn. on semen and testicular morphology of male wistar rats

Adenubi¹,

Raji²,

Awe³

et al. 2010

Science World Journal

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The effect of aqueous leaf extract of Boerhavia diffusa plant on the semen and testicular morphology of male Wistar rats was investigated. Thirty five rats were divided into seven groups of five animals each (Groups I-VII) with group I serving as the control. Distilled water (0.5 mls) was administered orally to rats in Group I (Control), while rats in the remaining six experimental groups (II-VII) were dosed orally with 50, 100 and 150mg/kg of 2.4% aqueous extract of B. diffusa for 60 days and then euthanized immediately (Grps II, IV & VI) or allowed to recover for one week before euthanasia (Grps III, V & VII). The serum testosterone level, weights and histopathology of the testes, epididymes and seminal vesicles were determined, and the spermatozoa from the cauda epididymes of the groups were studied. Data were compared using Man-whitney's test and analysis of variance (ANOVA). There was no significant difference in the serum testosterone level between treated rats and control. The weights of the testes, epididymes and seminal vesicles were however significantly (P<0.05) decreased in treated rats compared with the control. Sperm motility and sperm count decreased significantly (P<0.05) also in the treated rats compared with the control. In addition, the sperm live-dead ratio decreased significantly (P<0.05) in rats treated with 100 and 150mg/kg of the extract (Grps IV-VII) compared with the control. Histopathology of the testes of treated rats revealed marked degeneration of germinal epithelia with spermiostasis. This result suggests that aqueous extract of B. diffusa produced adverse effects in semen and testicular morphology of the rats.

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“…This plant is commonly known as red hogweed, tar vine, red spiderling, wineflower. Roots and leaves of this plant are used by many tribes in India for their anti-diabetic 3 , analgesic 4 , diuretic 5 , immunomodulatory 6,7,8 , anti-oxidant 9 , hepatoprotective 10 and anti-lymphoproliferative 11 properties. The root of B.diffusa contains alkaloids (punarnavine), rotenoids (boeravinones A-O), aminoacids, flavonoids, esacosanoic, stearic, β-sitosterols, tetracosanoic and ursolic acids 9,12 .…”

Section: Introductionmentioning

confidence: 99%

Isolation, Purification and Characterization of Boeravinone B From Boerhaavia Diffusa Linn.

Krishnamoorthy¹,

Muthukumaran²,

Maheswaran³

et al. 2017

Int. Res. J. Pharm.

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Boerhavia diffusa is a medicinal plant used in treatment of autoimmune diseases, cancers and inflammation. In the present study, methanolic extraction of roots of Boerhaavia diffusa was carried out and presence of Boeravinone B was identified from Thin Layer Chromatography and reverse phase HPLC. The methanolic root extract was run in TLC containing the mobile phase as toluene: ethyl acetate: methanol in the ratio (7:1:2). Retention factor for Boeravinone B in B.diffusa extract was found to be 0.461. RP-HPLC was carried out from the mobile phase consisting of acetonitrile and water at the ratio of 50:50 at 35 °C with a flow rate of 1.0 mL/min in C18 reverse phase column. Retention time of Boeravinone B was found to be 13.8 min. Linearity range of the concentration of extracted Boeravinone B was 5 -120 μg/ml and the correlation coefficient (R 2 ) value was found to be 0.997±0.003. Recovery was found to be 90.6% -92.8%. The limit of detection (LOD) of Boeravinone B was found to be 2 μg/ml and limit of quantitation (LOQ) was found to be 5 μg/ml. Presence of functional groups such as phenyl groups at 1450.47 cm -1 , 1591.27 cm -1 , C=C (Carbon skeleton) at 1618.28 cm -1 and Isoflavonoid structure at 1649.14 cm -1 of absorption spectra of isolated Boeravinone B were characterized by FTIR spectroscopy through recording absorption spectra. Thus, a rapid, economical and viable method was developed for isolation, purification and characterization of Boeravinone B.

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Antidiabetic activity of Boerhaavia diffusa L.: effect on hepatic key enzymes in experimental diabetes

Cited by 167 publications

References 22 publications

Phytochemical screening and in vitro bioactivities of the extracts of aerial part of Boerhavia diffusa Linn.

Phytochemical screening and in vitro bioactivities of the extracts of aerial part of Boerhavia diffusa Linn.

The effect of the aqueous extract of the leaves of <i>Boerhavia diffusa</i> Linn. on semen and testicular morphology of male wistar rats

Isolation, Purification and Characterization of Boeravinone B From Boerhaavia Diffusa Linn.

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