Antidiabetic and antidiarrhoeal effects on ethanolic extract of Psidium guajava (L.) Bat. leaves in Wister rats

Mazumdar, Santosh; Akter, Rasheda; Talukder, D.

doi:10.1016/s2221-1691(15)30163-5

Cited by 39 publications

(24 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Guava extract have anti diarrhoeal activity and it can be used for the treatment and prevention of diarrhaea [50]. Guava have significant antidiabetic and antidiarrhoeal activities in ethanolic extracts [51,52].…”

Section: Antidiarrheal Activitymentioning

confidence: 99%

The phytochemistry and medicinal value of Psidium guajava (guava)

et al. 2018

View full text Add to dashboard Cite

Psidium guajava (guava) is well known tropic tree which is abundantly grown for fruit. Many countries have a long history of using guava for medicinal purposes. This plant finds applications for the treatment of diarrhea, dysentery, gastroenteritis, hypertension, diabetes, caries and pain relief and for improvement in locomotors coordination. Its leaf's extract is being used as a medicine in cough, diarrhea, and oral ulcers and in some swollen gums wound. Its fruit is rich in vitamins A, C, iron, phosphorus and calcium and minerals. It contains high content of organic and inorganic compounds like secondary metabolites e.g. antioxidants, polyphenols, antiviral compounds, anti-inflammatory compounds. The phenolic compounds in guava help to cure cancerous cells and prevent skin aging before time. The presence of terpenes, caryophyllene oxide and p-selinene produces relaxation effects. Guava leaves contain many compounds which act as fungistatic and bacteriostatic agents. Guava has a high content of important antioxidants and has radio-protective ability. Quercetin is considered as most active antioxidant in the guava leaves and is responsible for its spasmolytic activity. Its ethyl acetate extract can stop the germ infection and thymus production. Guava possesses anti-viral, anti-inflammatory, anti-plaque and anti-mutagenic activities. Guava extract shows antinociceptive activity and is also effective in liver damage inflammation and serum production. Ethanolic extract of guava can increase the sperm quality as well as quantity and can be used for the treatment of infertile males.

show abstract

Section: Antidiarrheal Activitymentioning

confidence: 99%

The phytochemistry and medicinal value of Psidium guajava (guava)

et al. 2018

View full text Add to dashboard Cite

show abstract

“…It is cultivated in tropical and subtropical climatic zones of Pakistan and its leaves are used for the treatment of high blood pressure, cancer, inflammation, infection, diabetes, cough and other ailments (Sabeen & Ahmad 2009). Antimicrobial, antidiarrhoeal and other biological properties of P. guajava are of special interest for pharmaceutical and food industries (Arima & Danno 2002;Mazumdar et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, antioxidant, antitumor, anticancer and cytotoxic effects ofPsidium guajavaleaf extracts

Ashraf

Sarfraz

Rashid

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

Context Psidium guajava L. (Myrtaceae) leaves are used in traditional medicines for the treatment of cancer, inflammation and other ailments. Objective The current study explores scientific validation for this traditional medication. Materials and methods We used ferric-reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picryl hydrazil (DPPH) assays to estimate antioxidant activity of P. guajava leaf extracts (methanol, hexane and chloroform). Antitumour and in vivo cytotoxic activities were determined using potato disc assay (PDA) and brine shrimp lethality assay, respectively. Three human carcinoma cell lines (KBM5, SCC4 and U266) were incubated with different doses (10-100 mg/mL) of extracts and the anticancer activity was estimated by MTT assay. NF-kB suppressing activity was determined using electrophoretic mobility shift assay (EMSA). Chemical composition of the three extracts was identified by GC-MS. Total phenolic and flavonoid contents were measured by colorimetric assays. Results and discussions The order of antioxidant activity of three extracts was methanol4chloro-form4hexane. The IC 50 values ranged from 22.73 to 51.65 mg/mL for KBM5; 22.82 to 70.25 mg/mL for SCC4 and 20.97 to 89.55 mg/mL for U266 cells. The hexane extract exhibited potent antitumour (IC 50 value ¼ 65.02 mg/mL) and cytotoxic (LC 50 value ¼ 32.18 mg/mL) activities. This extract also completely inhibited the TNF-a induced NF-kB activation in KBM5 cells. GC-MS results showed that pyrogallol, palmitic acid and vitamin E were the major components of methanol, chloroform and hexane extracts. We observed significant (p50.05) difference in total phenolic and flavonoid contents of different solvent extracts. Conclusion The present study demonstrates that P. guajava leaf extracts play a substantial role against cancer and down-modulate inflammatory nuclear factor kB. ARTICLE HISTORY

show abstract

“…Anti-diabetic activity Alloxan induced diabetic test model [11] Streptozotocin (STZ)-induced diabetes mellitus mode [12] Anti-hyperlipidemic activity Lipase inhibition [13] Cardioprotective effects Ischemia-reperfusion injury using isolated perfused rat hearts [14] Ionotropic effect [15] Contractile effect on aortic rings in rat [16] Hypotensive effect Hypertensive Dahl salt-sensitive rats [12] Anti-proliferative activity Methylene blue assay [17] In vivo cytotoxic activity Brine shrimp cytotoxicity [18] In vitro anticancer assay MTT assay 2 ) in 10 mL de-ionized water was used as copper oxide ion donor [30]. Here, reduction and stabilization of copper oxide nanoparticles were achieved by aqueous extract of P. guajava leaves prepared by extraction of about 10 g of leaves powder with 100 mL of de-ionized water at 80°C for 3 h. They found these copper oxide nanoparticles spherical in shape.…”

Section: Metallic Nanoparticles Green Synthesized Using Guava Leavesmentioning

confidence: 99%

Psidium guajava leaves assisted green synthesis of metallic nanoparticles: a review

Patil

Rane²

2020

Beni-Suef Univ J Basic Appl Sci

View full text Add to dashboard Cite

Background Several attempts have been made for green synthesis of metallic nanoparticles, revealing the significance of plant extracts in reducing metal source to nanoparticles and applications in various domains of science. Main body Psidium guajava (guava) is evergreen, edible fruit-bearing plant, belonging to family Myrtaceae. Its leaves are reported to contain several phytochemicals like tannins, glycosides, terpenes, and triterpenes. This article focus on applications of Psidium guajava leaves extract in fabrication of nanoparticles of various metals like silver, gold, titanium dioxide, zinc oxide, and copper oxide. In respective research attempts, these metallic nanoparticles were evaluated for one or more applications like anti-microbial activity and/or photocatalytic activity. Conclusion Use of polar extract of guava leaves indicated involvement of its polar phyto-compounds in reducing the metal source and stabilizing the nanoparticles. In conclusion, it could be noted that metal nanoparticles have better anti-microbial activity and photocatalytic potential over aqueous leaves extract. Graphical abstract

show abstract

Antidiabetic and antidiarrhoeal effects on ethanolic extract of Psidium guajava (L.) Bat. leaves in Wister rats

Cited by 39 publications

References 16 publications

The phytochemistry and medicinal value of Psidium guajava (guava)

The phytochemistry and medicinal value of Psidium guajava (guava)

Chemical composition, antioxidant, antitumor, anticancer and cytotoxic effects ofPsidium guajavaleaf extracts

Psidium guajava leaves assisted green synthesis of metallic nanoparticles: a review

Contact Info

Product

Resources

About