Antidiabetic and Antilipidemic Effect of Musa balbisiana Root Extract: A Potent Agent for Glucose Homeostasis in Streptozotocin-Induced Diabetic Rat

Abstract

Folklore studies have revealed that Musa balbisiana Colla (MB; Family: Musaceae) has high medicinal properties. The purpose of the present study is to evaluate antihyperglycemic, and antioxidant activity of MB extracts in streptozotocin (STZ) induced diabetic rats. In vitro antioxidant and antidiabetic activity of MB extracts, i.e., root extract (RE), shoot extract and inflorescence extract were determined by using various methods viz 1,-1-diphenyl-2-picrylhydrazyl (DPPH) and a method to assess their possible effect on glucose diffusion across gastrointestinal tract and identify bioactive compound of potent extract. In vivo antilipidemic and antidiabetic activity was evaluated by administrating oral dose of RE for 15 days on STZ- induced diabetic rat. RE showed highest antioxidant activity by scavenging DPPH radical (IC50 32.96 μg/ml) and inhibit 30% glucose movement in vitro. The methanol extract of root showed the presence of calyx [4] arene category of the compound. Furthermore, RE treated rat revealed a reduction in fasting blood glucose (62.5%), serum total cholesterol (36.2%), triglyceride (54.5%), and low-density lipoprotein (50.94%) after 15 days as compared to STZ treated animal. There was an initiation of regenerative structures of the affected organs after 15 days of RE treatment. Histopathological observations clearly differentiate the structural changes in pancreas, liver, and kidney of STZ and RE treated group. The presence of calyx [4] arene class of compound may be responsible for its antioxidant and antidiabetic properties by absorbing glucose in vivo.

Antimicrobials tethering on suture surface through a hydrogel: a novel strategy to combat postoperative wound infections

“…The slides were examined under light microscope (LEICA EC3, Germany) for determination of pathological changes. [23][24][25] 3. Results…”

Musa balbisiana Fruit Rich in Polyphenols Attenuates Isoproterenol-Induced Cardiac Hypertrophy in Rats via Inhibition of Inflammation and Oxidative Stress

“…Musa balbisiana Colla (Family: Musaceae), commonly known as banana, is native to India and other parts of Asia and has been utilized in folk medicine since a long time by the tribal people of North-east India [5]. However, literature reviews have indicated that different banana species are utilized traditionally for the treatment of cardiac diseases, diabetes, inflammation, hypertension, diarrhoea, and dysentery [6,7].…”

“…However, literature reviews have indicated that different banana species are utilized traditionally for the treatment of cardiac diseases, diabetes, inflammation, hypertension, diarrhoea, and dysentery [6,7]. The root, stem juice, and ash of banana leaves are also utilized in venereal diseases and blood disorders and as an anthelmintic [5][6][7]. The World Health Organization (WHO) believes that a significant percentage of the population of developing countries rely on natural resources for their primary health care needs.…”

Isolation of flavonoids from Musa acuminata Colla (Simili radjah, ABB) and the in vitro inhibitory effects of its leaf and fruit fractions on free radicals, acetylcholinesterase, 15‐lipoxygenase, and carbohydrate hydrolyzing enzymes

“…Unfortunately, there is paucity of information on the bioactive compounds isolated from the leaves of Musa spp. Although antidiabetic effect of some Musa spp have been studied (Adewoye, Ige, & Latona, 2011;Bhaskar, Shobha, Sambaiah, & Salimath, 2011;Kalita et al, 2016) particularly on the flower and inflorescence part.…”