Antidiabetic, anti-oxidant and antimicrobial activities of Fadogia ancylantha extracts from Malawi

Nyirenda, KK; Saka, John D.K.; Naidoo, Devashan; Maharaj, VJ; Muller, Christo J. F.

doi:10.1016/j.jep.2012.07.002

Cited by 17 publications

(11 citation statements)

References 17 publications

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“…Nyirenda et al. () reported that polar compounds, such as phenolic compounds and flavonoids, were more soluble in aqueous solvents than in organic solvents. It was reported that the phenolic compound content of 50% hydroethanolic extract was higher than in the water extract of guava leaves (Qian and Nihorimbere ).…”

Section: Resultsmentioning

confidence: 99%

“…This result is consistent with previous reports showing that the phenolic compound content of water extract was higher than in pure ethanol and pure methanol extracts (Reddy et al 2012;Aktumsek et al 2013). Nyirenda et al (2012) reported that polar compounds, such as phenolic compounds and flavonoids, were more soluble in aqueous solvents than in organic solvents. It was reported that the phenolic compound content of 50% hydroethanolic extract was higher than in the water extract of guava leaves (Qian and Nihorimbere 2004).…”

Section: Resultsmentioning

confidence: 99%

“…; Nyirenda et al. ), and such plants with high antioxidant abilities can be used as natural medicines for preventing aging and chronic diseases (Kähkönen et al. ).…”

Section: Introductionmentioning

confidence: 99%

“…Medicinal plants have been used in the treatment and improvement of human diseases (Gutierrez et al 2008;Nyirenda et al 2012), and such plants with high antioxidant abilities can be used as natural medicines for preventing aging and chronic diseases (K€ ahk€ onen et al 1999). In addition, these plants have various physiologically active substances with anticancer and antimicrobial abilities (Bhanot et al 2011;Miyake and Hiramitsu 2011).…”

Section: Introductionmentioning

confidence: 99%

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Study to find the best extraction solvent for use with guava leaves (Psidium guajavaL.) for high antioxidant efficacy

Seo

Lee

Elam

et al. 2014

Food Science & Nutrition

125

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The effects of guava leaves extracted using solvents of water, ethanol, methanol, and different concentrations of hydroethanolic solvents on phenolic compounds and flavonoids, and antioxidant properties have been investigated. The antioxidant capability was assessed based on 2,2-diphenyl-1-picrylhydrazyl radical and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical-scavenging abilities, reducing power, and nitric oxide-and nitrate-scavenging activities. The results demonstrated that the antioxidant ability of guava leaf extracts has a strong relationship with phenolic compound content rather than flavonoid content. Phenolic compound content of water extracted guava leaves was higher compared to pure ethanol and methanol extracts. However, phenolic compound content extracted using hydroethanolic solvent was higher than water, whereas 50% hydroethanolic was observed to be the most effective solvent showing high antioxidant ability.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…; Nyirenda et al. ), and such plants with high antioxidant abilities can be used as natural medicines for preventing aging and chronic diseases (Kähkönen et al. ).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Study to find the best extraction solvent for use with guava leaves (Psidium guajavaL.) for high antioxidant efficacy

Seo

Lee

Elam

et al. 2014

Food Science & Nutrition

125

View full text Add to dashboard Cite

show abstract

“…Heat causes disintegration of the covalent bonds of phenolic compounds causing maximum increase in TPC (Ghimeray et al 2013). It may also be due to the fact that phenolic compounds and flavonoids, both polar compounds, display high solubility in aqueous solvents than in organic solvents (Nyirenda et al 2012).…”

Section: Pancreatic Lipase Inhibition Assaymentioning

confidence: 99%

.Phytochemical analysis of Elateriospermum tapos and its inhibitory effects on alphaamylase, alpha-glucosidase and pancreatic lipase

Nor-Liyana¹,

Siroshini²,

Nurul-Syahirah³

et al. 2019

JTFS

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Elateriospermum tapos contains high unsaturated fat and phytochemicals with many health benefits. This paper focuses on activities and inhibitory effects of E. tapos on digestive enzymes. Cold water, hot water and 70% ethanol extracts of the seed and shell of the fruit of E. tapos were used in this study. The extracts were screened for antioxidant activity, total phenolic content, total flavonoid content, and inhibitory effects on α-amylase, α-glucosidase and pancreatic lipase. Hot water extraction of shell of the E. tapos fruit had the highest total phenolic content (1298.60 ± 4. 24 µg GAE 100 g -1 ), total flavonoid content (16685.58 ± 487.77 µg CE 100 g -1 ) and antioxidant activity by 2, 2-diphenyl-2-picrylhydrazyl and β-carotene methods (84.16 and 122.17% respectively). The seed cold extract showed maximum α-amylase inhibition with IC 50 (half maximal inhibitory concentration) of 0.03 mg mL -1 . The lowest IC 50 (0.02 mg mL -1 ) for α-glucosidase inhibition was from seed ethanol extracts while shell cold extract had the lowest IC 50 for pancreatic lipase inhibition (37.80 mg mL -1 ). Results confirmed E. tapos as potential antioxidant and inhibitor of digestive enzymes for lipid (pancreatic lipase) and carbohydrate (α-amylase and α-glucosidase) which are beneficial to combat obesity and diabetes.

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Micellar electrokinetic chromatography fingerprinting combined with chemometrics as an efficient strategy for evaluating the quality consistency and predicting the antioxidant activity of Lianqiao Baidu pills

Chen

Sun

Yang

et al. 2017

J of Separation Science

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An approach combining micellar electrokinetic chromatography fingerprinting with chemometrics was developed to evaluate the quality consistency of Lianqiao Baidu pills, which are traditional Chinese patent medicines composed of 19 herbs used mainly to treat skin ulcers, common cold, rheumatism, herpes, and constipation. The triangle optimization method was employed to choose a satisfactory background electrolyte, with the information index, I, as an objective function for assessing the capillary electrophoresis conditions. Then, under the optimal conditions, the micellar electrokinetic chromatography fingerprints of 28 batches of samples were established, and five marker compounds were quantitatively determined simultaneously. A limited-ratio quantified fingerprint method was introduced to evaluate the chromatographic fingerprints both qualitatively and quantitatively. Principle component analysis revealed that the 28 batches of samples can be clustered according to different manufacturers. Moreover, the relationship between the fingerprint and the antioxidant activity was explored by orthogonal partial least-squares regression, which provided critical medicinal efficacy information for quality control. The present study establishes a powerful and reliable method for monitoring the quality consistency of Lianqiao Baidu pill.

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Antidiabetic, anti-oxidant and antimicrobial activities of Fadogia ancylantha extracts from Malawi

Cited by 17 publications

References 17 publications

Study to find the best extraction solvent for use with guava leaves (Psidium guajavaL.) for high antioxidant efficacy

Study to find the best extraction solvent for use with guava leaves (Psidium guajavaL.) for high antioxidant efficacy

.Phytochemical analysis of Elateriospermum tapos and its inhibitory effects on alphaamylase, alpha-glucosidase and pancreatic lipase

Micellar electrokinetic chromatography fingerprinting combined with chemometrics as an efficient strategy for evaluating the quality consistency and predicting the antioxidant activity of Lianqiao Baidu pills

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