Antidiabetic Aptitude of Cordia sebestena and its Outcome on Biochemical Parameters, Serum Electrolytes, and Hematological Markers

Abstract

Diabetes is a metabolic disorder which evolves from imperfect insulin action and secretion. 1 In congruence with the International Diabetes Federation, diabetes is among the utmost gigantic health hassles. The planetary preponderance of hyperglycemic patients is hypothesized to augment from 415 million in 2015 to 642 million by 2040, symbolizing the escalation of 35.5% in the next 25 years. 2 Diabetes inaugurates multiple organ ruination including eyes, kidneys, liver, heart, and blood vessels. 3 Conventionally, blood investigation is one of the screening proceedings to authenticate general health. Glucose, cholesterol, calcium, total protein, alkaline phosphates, uric acid, sodium, potassium, and chloride levels are indicative values for diabetes mellitus 4 and its associated diseases such as coronary artery disease, dyslipidemia, 5] diabetic nephropathy, 6 chronic hepatopathy, and liver disease. 7 Innumerable plants are affluent source of antidiabetic consequence and have been practiced in

Comparative study of aqueous, methanol and petroleum ether extracts of unripe Carica papaya seed on liver and kidney function in streptozotocin-induced diabetic rats

“…However, glycosuria discovered in diabetes leads to excretion of abundant water, Na + , and K + in urine. Hence, it is evidenced that electrolytes and water loss associated with diabetes would result in loss of ECF, resulting in loss of Na + and K + concentration 50,51 . Hyponatremia is a decrease in serum Na + concentration which is often observed in uncontrolled hyperglycemia and it may result in cognitive impairment, osteoporosis and fractures 52 .…”

A comprehensive review on management of Parkinson’s disease, inclusive of drug discovery and pharmacological approaches

“…27) was developed back in the late 1950s; all of these drugs contained catechol groups, such as gallic acid (58), caffeic acid (59), U-0521 (60), 2-hydroxyoestrogen (61), and flavonoids like quercetin (62). However, there are numerous reports available, revealing the inhibition of COMT by some plant-derived alkaloids and phenolics (Abdel-Moty et al, 1998;Chaudhary et al, 2016Chaudhary et al, , 2018aChaudhary et al, , 2018bChaudhary et al, , 2019Chaudhary et al, , 2020El-Shorbagi et al, 2015Mohamed et al, 1993;Soliman et al, 2019;Vieira-Coelho et al, 1996). These drugs have undergone insufficient clinical trials, so they are not actually used as medicines due to unsatisfactory selectivity, toxicity, and disadvantageous pharmacokinetics (Backstrom et al, 1989;Ruottinen and Rinne, 1998).…”