Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin-induced diabetic rats

Maiti, Rajkumar; Jana, Debasis; Das, Uttam Kumar; Ghosh, Debidas

doi:10.1016/j.jep.2004.02.002

Cited by 257 publications

(173 citation statements)

References 14 publications

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“…[1][2][3] According to the World Health Organization, about 80% of the people in the world use medicinal herbs to treat and prevent diseases instead of primary medical assistance because of low prices and the ease of obtaining such medicinal plants. 4 Literature data confirm the significant effects of alternative medicine to control hyperglycemia 5,6 and lipid levels. [7][8][9] Hypercaloric diets are very common nowadays and increase the occurrence of hypercholesterolemia and low levels of high-density lipoprotein-cholesterol (HDL-c), resulting in higher risks of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 78%

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Souza

Barbalho

Damasceno

et al. 2012

Journal of Medicinal Food

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The aim of this study was to evaluate the effects of Passiflora edulis f. flavicarpa Degener (yellow passion) juice on the lipid profile and oxidative stress status of Wistar rats. Adult male Wistar rats were divided in two groups (n = 8 animals per group): the control group, which received water, and the treated group, which was given P. edulis juice (1,000 mg/kg). Both groups received by gavage treatment twice a day for 28 days. The treated group showed an increased high-density lipoproteincholesterol level and decreased low-density lipoprotein-cholesterol and free fatty acid levels compared with the control group. Levels of triglycerides and and very low-density lipoprotein-cholesterol, superoxide dismutase activity, and total glutathione concentration were not statistically different between the two groups, but the thiobarbituric acid-reactive substances concentration (indicating lipid peroxidation) decreased in the treated group. These findings suggests that P. edulis juice in the experimental conditions used showed beneficial effects on lipid profile and improved lipid peroxidation in Wistar rats.

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Section: Introductionmentioning

confidence: 78%

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Souza

Barbalho

Damasceno

et al. 2012

Journal of Medicinal Food

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“…22) In our previous work we have reported the antidiabetic effect of some of these plant parts in separate and in composite manner but not these four plant parts in a single formula. [23][24][25][26] In this experiment an approach has been considered to find out the composite effect of these four plant parts in a single formula on the basis of previous idea that composite extracts of plants are used as the drug of choice rather than individual and many of these shown promising effects. 27) In this study an attempt has been taken to strengthen the idea about the testicular disorders noted in diabetes and to evaluate the antidiabetic potency and the remedial effect of the herbal formulation known as MTEC on testicular dysfunction in diabetic state.…”

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confidence: 99%

Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat

Mallick

Mandal

Barik

et al. 2007

Biological & Pharmaceutical Bulletin

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Diabetes is associated with declining sexual function in both male 1) and female 2) individuals. In case of female, diabetic symptoms consistent with autonomic neuropathy associated with decreased subjective sexual arousal. 3) In recent study Erol et al. noted that women with type 2 diabetes experienced higher prevalence rates of sexual dysfunction when compared to non diabetic. 4) Approximately 80% of diabetic patients complained loss of libido, 60% had diminished clitoral sensitivity, 50% experienced organic dysfunction, 40% experienced vaginal discomfort, and 40% experienced vaginal dryness. 5) Type 1 diabetic women experienced higher prevalence of reduced vasocongestion and reduced vaginal lubrication to erotic stimuli. 6) Thus these clinical studies suggest that both type 1 and type 2 impede the sexual arousal responses in women.Male reproductive alterations have been widely reported in model animals and human with diabetes. 7) Streptozotocin induced diabetes in male rats resulted atrophy of sex organ, changes in histoarchitecture of ventral prostate, 8) diminution in sperm count, 8) along with low levels in plasma gonadotrophins 9,10) and testosterone. 11) The copulatory behavior of diabetic rat has been collapsed 12) along with low fertility in induced normal mating. 12) In human, diabetes is associated with erectile dysfunction 13,14) along with loss of libido 1,5) and abnormal morphology of sperm, low plasma levels of gonadotrophins and testosterone. 15) Though there are several reports about dysfunctions of the male reproductive activity in diabetic state but the data are confusing, and the exact role that insulin plays in the regulation of male reproductive function is still unclear.In traditional practice, medicinal plants are used in many countries to control diabetes mellitus. The National Centre for Complementary and Alternative Medicine, established in 1998 by the United States Government where development of herbal medicine is one of the important subjects of study. 16,17) Moreover the herbal drug is of first choice at present because plant drugs are to be less toxic and more free from side effect than synthetic one. 18) M. paradisiaca is a tree like herb belonging to the Musaceae family and different parts of the plant have medicinal value. 19,20) T. indica LINN is tree type of plant belonging to the Caesalpiniaceae family was used as a traditional medicine for the management of diabetes mellitus. 21) E. Jambolana is used as traditional medicine for the management of diabetes. 19) This plant is found all over India and belongs to the Myrtaceae family. Jambu bark cure hemorrhages, burning sensation, dysentery, diarrhea, diabetes, excessive thirst, dyspepsia, cough and asthma and is used in preparation of astringent decoction for gargles and washes. 20) Seeds are used for the treatment of diabetes. 20) Coccinia indica is under Cucurbitaceae family and has medicinal importance as observed earlier by others. 22) In our previous work we have reported the antidiabetic effect of some of these plant pa...

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“…One possible effect of antidiabetic drugs can be improvement of glycogenesis (Maiti et al, 2004). Diabetic control group showed significant decrease in liver glycogen content while treatment with TG for 42 days resulted in significant and dose dependant elevation of the liver glycogen content.…”

Section: Resultsmentioning

confidence: 99%

Antihyperglycemic and lipid lowering effect of Tectona grandis in alloxan induced diabetic rats

Ghaisas¹,

Navghare²,

Takawale³

et al. 2010

Oriental Pharmacy and Experimental Medicine

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SUMMARYIn India, Tectona grandis is traditionally used in the treatment of diabetes mellitus and lipid disorder. In the present study, the antihyperglycemic and lipid lowering effect of ethanolic extract of bark of Tectona grandis (TG) was evaluated using alloxan induced diabetes in rats. Alloxan was given at the dose of 140 mg/kg, i.p. After induction of diabetes, TG was administered for 42 days p. o. and simultaneously different biochemical parameters like plasma glucose, liver glycogen content, serum triglyceride, cholesterol, LDL-cholesterol and HDL-cholesterol were estimated. Diabetic control showed significant increase (P < 0.01) in plasma glucose, serum triglyceride, cholesterol, LDL-cholesterol and significant decrease (P < 0.01) in serum HDL-cholesterol and liver glycogen content. Treatment with TG showed significant reduction (P < 0.01) in plasma glucose when compared with diabetic control. The elevated levels of serum triglyceride and cholesterol levels were significantly reduced (P < 0.01) by TG. TG treatment for 42 days showed significant decrease in serum LDL-cholesterol (P < 0.01) and significant increase in serum HDLcholesterol level (P < 0.01). Moreover, diabetic control there was significant decrease in liver glycogen content which was significantly increased (P < 0.05) by treatment with TG. Hence, from the result obtained in the present study it can be concluded that Tectona grandis has the potential to treat diabetes condition and associated lipid disorder.

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Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin-induced diabetic rats

Cited by 257 publications

References 14 publications

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat

Antihyperglycemic and lipid lowering effect of Tectona grandis in alloxan induced diabetic rats

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