Antidiabetic Effect of<i>Boerhavia diffusa</i>: Effect on Serum and Tissue Lipids in Experimental Diabetes

Pari, Leelavinothan; Satheesh, M. Amarnath

doi:10.1089/jmf.2004.7.472

Cited by 45 publications

(23 citation statements)

References 22 publications

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“…Partial restoration of the pancreatic islet cells after treatment with the extract indicate that the possible mechanism by which the methanolic extract of F. aestuans reduced blood glucose levels of the diabetic rats may be either by increasing the pancreatic secretion of insulin from the islet of Langerhan's or it is released from bound insulin. Similar result has been reported (Pari et al, 2004). Recently, Mgbeje et al (2016) found that there was a significant reduction in the blood glucose levels of rats treated with n-hexane fraction of Heinsia crinite whencompared with the diabetic control (Mgbeje et al, 2016).…”

Section: Discussionsupporting

confidence: 76%

Anti-diabetic activities of Fleurya aestuans (L.) Gaudich in alloxan induced rats

Fagbohun¹,

Jaiyesimi²,

Adegboyega³

et al. 2017

Afr. J. Pharm. Pharmacol.

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Diabetes mellitus is becoming an increasing concern all over the world and such people especially in some communities have used medicinal plants to treat diabetes and its complications. This investigation aimed to examine the hypoglycemic potential of the methanol extract of Fleurya aestuans leaves in normal and alloxan induced diabetic rats. Thirty five Wistar albino rats were grouped into seven different groups of five per group where diabetes was induced in the rats by intra peritoneal administration of alloxan monohydrate (150 mg/kg) except a control group. F. aestuans methanol extract at a dose of 100, 200, 300 and 400 mg/kg of body weight were administered at a single dose per day for a period of 10 days to the diabetic rats, respectively. Five mg/kg of standard drug, glibenclamide (a positive control) was given to one of the groups. The effects of F. aestuans methanol extract of whole plant, on blood glucose was measured in the diabetic rats. This activity is not dose dependent.

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Section: Discussionsupporting

confidence: 76%

Anti-diabetic activities of Fleurya aestuans (L.) Gaudich in alloxan induced rats

Fagbohun¹,

Jaiyesimi²,

Adegboyega³

et al. 2017

Afr. J. Pharm. Pharmacol.

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“…Phospholipids are vital part of biomembrane rich in PUFA, which are susceptible substrate for free radicals such as O 2 •- and OH • radicals [42]. Increased phospholipids levels in tissues were reported by [43,44] in streptozotocin diabetic rats. Administration of Diasulin decreased the levels of tissue free fatty acids and phospholipids.…”

Section: Discussionmentioning

confidence: 99%

Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats

Saravanan

Pari

2005

BMC Complement Altern Med

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BackgroundThis study was undertaken to investigation the effect of Diasulin, a poly herbal drug composed of ethanolic extract of ten medicinal plants on blood glucose, plasma insulin, tissue lipid profile, and lipidperoxidation in alloxan induced diabetes.MethodsEthanolic extract of Diasulin a, poly herbal drug was administered orally (200 mg/kg body weight) for 30 days. The different doses of Diasulin on blood glucose and plasma insulin in diabetic rats were studied and the levels of lipid peroxides [TBARS, and Hydroperoxide] and tissue lipids [cholesterol, triglyceride, phospholipides and free fatty acids] were also estimated in alloxan induced diabetic rats. The effects were compared with glibenclamide.ResultTreatment with Diasulin and glibenclamide resulted in a significant reduction of blood glucose and increase in plasma insulin. Diasulin also resulted in a significant decrease in tissue lipids and lipid peroxide formation. The effect produced by Diasulin was comparable with that of glibenclamide.ConclusionThe decreased lipid peroxides and tissue lipids clearly showed the antihyperlipidemic and antiperoxidative effect of Diasulin apart from its antidiabetic effect.

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“…Phospholipids are present in cell membrane and make up the vast majority of the surface lipoprotein forming a lipid bilayer that acts as an interface with both polar plasma environment and non-polar lipoprotein of lipoprotein core [58]. Increased phospholipids level in tissues was reported by Venkateswaran et al [59] and Pari and Satheesh [60] in streptozotocin-induced diabetic rats. Administration with the stem and leaf ethanol extracts of B. nervosa and glibenclamide decreased the level of phospholipids.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic Activity of Bacolepis Nervosa (Wight and Arn.) Decne. Ex Moq. Extract on Alloxan Induced Diabetic Rats

Alphonse¹,

Mohan

Doss

2016

Int J Pharm Pharm Sci

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Objective: The aim of this study was to investigate the effect of ethanol extracts of stem and leaf of Bacolepis nervosa as antihyperglycemic, antihyperlipidemic and antioxidant activity in alloxan-induced diabetic rats.Methods: Diabetes was induced in wistar albino rats by administration of alloxan monohydrate (150 mg/kg). The ethanol extract of B. nervosa leaf and stem at a dose of 150 and 300 mg/kg body weight was administrated at a single dose per day to diabetes-induced rats for a period of 14 d. The effect of ethanol extract of B. nervosa leaf and stem on blood glucose, insulin, urea, creatinine, HbA1Results: The ethanol extract of B. nervosa stem and leaf elicited significant reduction in blood glucose (p<0.001), serum enzymes (SGPT, SGOT, ALP) (p<0.01), lipid parameters (TC, TG, VLDL-LDL, PL) (p<0.01) except HDL-C and significantly increased insulin (p<0.01), HDL-C (p<0.05),, GPx, GSH, SOD and CAT (p<0.05) at the dose of 300 mg/kg when compared with the diabetic-induced control.C, serum protein, albumin, globulin, serum enzymes, serum lipid profiles, lipid peroxidase (LPO) and antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) were measured in the diabetic rats. Conclusion:From the above results, it is concluded that ethanol extracts of B. nervosa leaf and stem possesses significant antihyperglycemic, antihyperlipidemic and antioxidant effect in alloxan induced diabetic rats.

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Antidiabetic Effect ofBoerhavia diffusa: Effect on Serum and Tissue Lipids in Experimental Diabetes

Cited by 45 publications

References 22 publications

Anti-diabetic activities of Fleurya aestuans (L.) Gaudich in alloxan induced rats

Anti-diabetic activities of Fleurya aestuans (L.) Gaudich in alloxan induced rats

Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats

Antidiabetic Activity of Bacolepis Nervosa (Wight and Arn.) Decne. Ex Moq. Extract on Alloxan Induced Diabetic Rats

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