Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

Abstract

Background: Diabetes mellitus (DM) is one of the most common endocrinal diseases characterized by hyperglycemia and altered metabolism of lipids, carbohydrates, and proteins with an increased risk of many complications. Bioactive drugs extracted from natural sources had been used in a wide range of treatment for many diseases. This work aimed to investigate the potential antidiabetic effect of Egyptian honey bee venom (BV) in alloxan-induced diabetic rats. Subjects and methods: Forty adult male albino rats (140-180 g) were used in the study and divided into five groups each of eight rats. The normal control group, diabetic group, high-and low-dose BV-treated groups, and vildagliptintreated group. Blood samples and pancreases were collected after 6 weeks of the experiment. Results: Treatment of diabetic rats with BV revealed a significant decrease in serum glucose level accompanied by a significant increase in insulin level. Malondialdehyde (MDA), cholesterol, triglycerides, creatinine, and aminotransferases (ALT and AST) levels were significantly decreased after BV treatment in comparison with diabetic animals. Total antioxidant capacity (TAC), glutathione (GSH) contents, and catalase (CAT) activity had improved. Histological examination of the pancreas indicated a marked improvement in the islet architecture and marked regeneration of insulin-secreting β-cell in diabetic BV-treated rats. Conclusion: The study concluded that BV could have the ability to lower glucose level in diabetic rats and enhance insulin secretion, and relieved the various biochemical and histological abnormalities resulted due to diabetes metabolic disorders.

Physicochemical properties, total phenolic content, and antioxidant activity of chestnut, rhododendron, acacia and multifloral honey

“…Due to its therapeutic features, there are many studies available on the beneficial effects of honey on human biological processes including antioxidant [ 1 , 3 ], antimicrobial [ 4 – 6 ], wound healing [ 7 , 8 ], antidiabetic [ 9 , 10 ], anti-inflammatory [ 11 , 12 ], and anticancer [ 13 , 14 ] activities. Furthermore, owing to its antiviral effects [ 15 ], honey has been applied in clinical trials in the USA and Egypt hoping to discover potential curing effects against the current COVID-19 pandemic [ 16 ].…”

Effect of Honeybee Venom (Apis Mellifera) on Respiratory Functions of Hypercholesterolemic Male Albino Rats

“…Bee venom can have therapeutic, defensive, and hypolipidemic effects by increasing lipid consumption in adipose tissue and triglyceride hydrolysis (Hassan et al, 2019). Treatment with cholesterol, induced decreases in levels of Hb, Hct, and RBCs count.…”

Ganoderma applanatum mushroom provides new insights into the management of diabetes mellitus, hyperlipidemia, and hepatic degeneration: A comprehensive analysis

“…Blood glucose level measured after 3 days. Animals with blood glucose levels equal to 200 mg/dl or above were considered diabetic and used in the experiment (Hassan et al., 2019 ).…”