Ganoderma applanatum mushroom provides new insights into the management of diabetes mellitus, hyperlipidemia, and hepatic degeneration: A comprehensive analysis

Abstract

Diabetes mellitus is a metabolic disorder characterized by a relative or total insulin deficit and hyperglycemia (Karunasagara et al., 2020). Diabetic patients suffer from numerous disorders, including vascular illness, like atherosclerosis, neuropathic pain, and diabetes neuropathy (Papatheodorou et al., 2018). According to the report of 2019, 463 million individuals between the ages of 20 and 79 are estimated to have diabetes globally (Saeedi et al., 2019). By 2045, the number of affected people with diabetes is expected to increase to 700 million worldwide. Bangladesh has been in the top ten positions in the world for the number of adults (20-79 years) with diabetes (8.4 million) in 2019. The prevalence of diabetes will be increased to 15.0 million by 2045. Bangladesh has also been ranked nine in 2019 among the countries for 4.7 million adults with undiagnosed diabetes (Atlas, 2015;

Polyphenol Extracts From Germinated Mung Beans Can Improve Type 2 Diabetes in Mice by Regulating Intestinal Microflora and Inhibiting Inflammation

“…Glucose tolerance refers to the body's ability to tolerate glucose according to the degree of glucose tolerance, judge the ability of islet β cells to regulate blood glucose ( 24 ). Blood glucose area under curve (AUC) can indicate the degree of glucose utilization and clearance by the human body.…”

LC/MS analysis of mushrooms provided new insights into dietary management of diabetes mellitus in rats

“…In literature, the mushrooms showed different polysaccharides and their effect on diabetes, for example, G. lucidum (polyheterosaccharides); P. ostreatus , (polyheterosaccharides); P. citrinopileatus (acid polysaccharide); L. edodes (glucan, heteropolysaccharides); and H. marmoreus (glycoprotein). Chlorella pyrenoidosa polysaccharides with a low molecular weight (>3000 Da) showed an hypolipidemic effect in rat (Agunloye & Oboh, 2022 ; Hossain et al, 2021 ; Jayasuriya et al, 2015 ; Qiu et al, 2022 ). Chisandra sphenanthera polysaccharide (191.18 kD) showed antidiabetic effect in rats with type 2 diabetes (Niu et al, 2017 ).…”

“…marmoreus (glycoprotein). Chlorella pyrenoidosa polysaccharides with a low molecular weight (>3000 Da) showed an hypolipidemic effect in rat (Agunloye & Oboh, 2022;Hossain et al, 2021;Jayasuriya et al, 2015;Qiu et al, 2022). Chisandra sphenanthera polysaccharide (191.18 kD) showed antidiabetic effect in rats with type 2 diabetes (Niu et al, 2017).…”

Biological Functions of Dillenia pentagyna Roxb. Against Pain, Inflammation, Fever, Diarrhea, and Thrombosis: Evidenced From in vitro, in vivo, and Molecular Docking Study

“…In Chimera, the residues were retained in AMBER ff14sB mode and Gasteiger mode. As a result, all proteins have been shrunk to the least level of energy ( 35 ).…”