Antidiabetic potential of Citrus sinensis and Punica granatum peel extracts in alloxan treated male mice

Abstract

An investigation on the effects of four different concentrations of peel extract from Citrus sinensis (CS) or Punica granatum (PG) in male mice revealed the maximum glucose lowering and antiperoxidative activities at 25 mg/kg of CS and 200 mg/kg of PG. In a separate experiment their potential was evaluated with respect to the regulation of alloxan induced diabetes mellitus. While a single dose of alloxan (120 mg/kg) increased the serum levels of glucose and alpha-amylase activity, rate of water consumption and lipid peroxidation (LPO) in hepatic, cardiac and renal tissues with a parallel decrease in serum insulin level, administration of 25 mg/kg of CS or 200 mg/kg of PG was found to normalize all the adverse changes induced by alloxan, revealing the antidiabetic and anti peroxidative potential of test fruit peel extracts. Subsequent phytochemical analysis indicated that the high content of total polyphenols in the test peels might be related to the antidiabetic and antiperoxidative effects of the test peels.

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

“…Cyclic monoterpene, DL-limonene [218]. Ascorbic acid [219] Maximum glucose lowering and antiperoxidative activities in alloxan diabetic mice [220]. Antithyroidal, hypoglycemic, and insulin stimulatory properties, suggesting its potential to ameliorate both hyperthyroidism and diabetes mellitus [221].…”

Medicinal plants with antidiabetic effects (part 2): plant based review

“…In a separate experiment their potential was evaluated with respect to the regulation of alloxan induced diabetes mellitus. While a single dose of alloxan (120 mg/kg) increased the serum levels of glucose and alpha-amylase activity, rate of water consumption and lipid peroxidation (LPO) in hepatic, cardiac and renal tissues with a parallel decrease in serum insulin level, administration of 25 mg/kg of CS was found to normalize all the adverse changes induced by alloxan, revealing the antidiabetic and anti peroxidative potential of tested fruit peel extracts [59].…”

Anticancer, Anti HIV-1 and Antimicrobial Potentials of Methanol Extract and Non Polar Fractions of Citrus volkameriana Leaves and Phytochemical Composition

“…Recently, a lot of researches have been done concerning the bioactivities citrus byproducts. Results have shown that citrus extract exerted many bioactivities including anticancer (Visalli et al, 2014), antioxidant, analgesic, anti-inflammatory (Sood et al, 2009), antiulcer (Bhavitavya et al, 2012), hepatoprotective (Abirami et al, 2015), cardioprotective (Campelo et al, 2011), anxiolytic (Carvalho-Freitas and Costa, 2002), antiviral (Balestrieri et al, 2011), anti-microbial (Shende et al, 2015) antiobesity (Cardile et al, 2015) and antidiabetic activity (Parmar and Kar, 2007). These actions were correlated to the wide variety of secondary metabolites produced by citrus including polyphenolic compounds, alkaloids, limonoids, pectins and dietary vitamin C (Benavente- Garcia and Castillo, 2008;Marti et al, 2009;Murakami et al, 1997;Silalahi, 2002;Tundis et al, 2014;Visalli et al, 2014).…”