Antidiabetic properties and metal analysis of Bombax ceiba flower extracts

Abstract

The plant may be considered a bio-synthetic laboratory, not only for the bio-chemicals such as carbohydrates, protein, and lipid that are utilized as food by man, but also for a multitude of compounds like glycosides, alkaloids, tannins etc, that exerts physiological effects. The compound those are responsible for therapeutic effects are usually the secondary metabolite. Bombex ceiba plant extracts have been evaluated for its antidiabetic properties by in-vitro inhabitation of alpha amylase and alpha glucosidase enzymes. The results so far obtained are encouraging by showing inhibition of these enzymes to a large extent. The water and ethanolic extracts of all the plant parts (thalamus and flower) show the highest inhibition as compared to DCM extracts.The corresponding IC50 values are as thalamus DCM extract 36.22, ethanolic extract 35.32, and water extract 31.31and the flower DCM extract 38.13, ethanolic extract 35.23, and water extract 33.00. The water, ethanolic and DCM extract of thalamus shows the concentration of sodium as 340, 310, 120 (ppm), potassium as 151, 180, 98 (ppm), lithium 31, 25, 11(ppm) and that of calcium 110, 80, 89 (ppm). The water, ethanolic and DCM extract of flower shows the concentration of sodium as 300, 295, 95 (ppm), potassium as 149, 175, 81 (ppm), lithium 28, 20, 05 (ppm) and that of calcium 95, 75, 64 (ppm).

A preliminary study of the chemical composition and bioactivity of Bombax ceiba L. flower and its potential mechanism in treating type 2 diabetes mellitus using ultra-performance liquid chromatography quadrupole-time-flight mass spectrometry and network pharmacology analysis

“…This also proved that α-glucosidase inhibitory activity was the combined effect of various bioactive substances in BCF. Previous studies have reported the hypoglycemic activity of BCF in vitro and in vivo ( 36 , 37 ), which was in accordance with our experimental results. Given that the in vivo hypoglycemic activity of the n-BuOH and EtOAc fractions merit further investigation.…”

Bombax ceiba flowers extract ameliorates hepatosteatosis induced by ethanol and relatively moderate fat diet in rats

“…The Phytochemical compositions of methanol extract of the Egyptian B. ceiba flowers indicate the presence of alkaloids, flavonoids, glycosides, saponine, polyphenols, tannins, proteins, carbohydrates, lipids, amino acids and coumarins [33,34]. These valuable compounds offer the potent antioxidant and hypolipedimic properties of BCE in the liver tissues [35].…”

Isolation and Analysis of Characteristic Compounds from Herbal and Plant Extracts

“…It is possible to consider metabolic pathways as groups of metabolites that share a common biological process and are related by one or more enzymatic reactions. A broad set of metabolic pathways are covered by comprehensive metabolic pathway databases, such as the KEGG database [173], MetaCyc [174], AraCyc [175] and the small molecule pathway database (SMPDB) [176] (Table 5). A number of software, such as, metabolite set enrichment analysis (MSEA), MPEA, IMPaLA, MBRole, VANTED, Metabo-Analyst, Paintomics, ProMeTra, Metscape2, and MetaMapRR can perform statistical and other metabolite enrichment analyses (Table 5).…”

“…Bombax ceiba L. The dichloromethane, ethanol, and aqueous thalamus and flower extracts of B. ceiba were reported for their antidiabetic properties in terms of their capacity to inhibit alpha-amylase and alpha-glucosidase enzymes under in vitro condition. The corresponding IC 50 values for alpha-amylase inhibition activities for thalamus were 36.22 µg/mL (dichloromethane extract), 35.32 µg/mL (ethanolic extract), and 31.31 µg/mL (aqueous extract) and for flowers, 38.13 µg/mL (dichloromethane extract), 35.23 µg/mL (ethanolic extract), and 33.00 µg/mL (aqueous extract) [174]. The n-hexane fraction of sepals [175] and ethanolic leaf extracts [177] of B. ceiba exhibited antidiabetic activities in STZ-induced diabetic rats.…”