Antiedematogenic effects of the polar fractions of Persea cordata Mez. (Lauraceae) on microvascular extravasation in rat skin

Schlemper, Valfredo; Schlemper, Susana Regina de Mello; Zampirolo, Júlio Araújo

doi:10.1016/j.jep.2013.08.035

Journal of Ethnopharmacology

2013

DOI: 10.1016/j.jep.2013.08.035

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Antiedematogenic effects of the polar fractions of Persea cordata Mez. (Lauraceae) on microvascular extravasation in rat skin

Valfredo Schlemper

Susana Regina de Mello Schlemper

Júlio Araújo Zampirolo

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Cited by 3 publications

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“…were evaluated for their anti-inflammatory activity, Poikilacanthus glandulosus (Nees) Ariza(de Brumm et al, 2016), Persea cordata Meisn(Schlemper et al, 2013), Macrosiphonia longiflora (Desf.) Müll.Arg.…”

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Ethnopharmacological studies in 21st century Brazil: a systematic review

Silva

Carvalho

Benevides

2022

RSD

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Brazil is a country with a large party of the population, including traditional communities, that use plants for medicinal purposes, however, the prospect of drugs derived from plants is still little explored. The present study aimed to carry out a systematic review of the literature, in an attempt to understand how studies involving ethnopharmacology have developed in Brazil during the 21st century. The Scielo and PubMed data bases were used, using the keywords “ethnopharmacology” and “Brazil”. In a total of 212 articles were selected and the highest number of publications in the years of, respectively: 2018 (9.43%), 2020 (8.96%) and 2014 (8.96%). Experimental studies (laboratory studies, such as phytochemicals and biological activity) accounted 41.98% of the total, followed by literature reviews (36.32%) and ethno-directed interviews (20.28%). The results showed that the most common types of studies were popular use and biological activity (33.96%), followed by studies of popular use, phytochemical composition and biological activity (21.70%) and ethno-directed survey (20.75%). The most cited botanical families were Fabaceae (8.49%), Asteraceae (5.19%) and Lamiaceae (2.83%) and the main biological activities evaluated were anti-inflammatory (10.85%), antimicrobial (10 .85%), antimalarial (5.19%) and antioxidant (4.72%). Among the traditional communities surveyed were rural communities (50%) and quilombola communities (13.64%). The present study indicates that there was a significant increase in publications involving ethnopharmacology in Brazil, mainly from 2010, associated with a greater diversification of the researched objectives.

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mentioning

confidence: 99%

Ethnopharmacological studies in 21st century Brazil: a systematic review

Silva

Carvalho

Benevides

2022

RSD

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Persea americana Mill. crude extract exhibits antinociceptive effect on UVB radiation-induced skin injury in mice

et al. 2018

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Persea americana, popularly known as avocado, has been empirically used as analgesic and anti-inflammatory including in the skin disorder treatment. Species of the genus Persea also show a photoprotective effect against UVB radiation. We investigated the antinociceptive and anti-inflammatory effects from a topical formulation containing the P. americana leaf extract in a UVB irradiation-induced burn model in mice and performed a gel-formulation stability study. The antinociceptive and anti-inflammatory effect was evaluated through mechanical allodynia, paw oedema, and inflammatory cell infiltration. Phenolic compounds were quantified by UHPLC-MS/MS. The gel-formulation stability study was performed analyzing organoleptic characteristics, pH, and viscosity. P. americana (3%) gel was able to prevent the UVB irradiation-induced mechanical allodynia on the 2nd and 3rd day after irradiation with maximum inhibition of 60 ± 12% at 2nd day. Such effect may be attributed, at least in part, due the presence of (+)-catechin (302.2 ± 4.9 μg/g) followed by chlorogenic acid (130 ± 5.1 μg/g) and rutin (102.4 ± 0.9 μg/g) found in the extract. The gel was not able to prevent the inflammatory parameters such as edema and leukocyte infiltration induced by UVB irradiation. No changes important were detected in the stability study, mainly in low temperature. Our results suggest that P. americana gel-formulation, which presented stability, ensuring its quality and the therapeutic effect, could be an interesting strategy for the treatment of the pain associated with sunburn; this effect could be attributed to its biological constituents, especially catechin, chlorogenic acid, and rutin.

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Inhibitory effect of hydroalcoholic extract of Cunila spicata Benth. on phlogistic agents-induced cellular migration in the airways of mice

Schlemper

Molin

Frankenberger

et al. 2023

Journal of Ethnopharmacology

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Antiedematogenic effects of the polar fractions of Persea cordata Mez. (Lauraceae) on microvascular extravasation in rat skin

Cited by 3 publications

References 41 publications

Ethnopharmacological studies in 21st century Brazil: a systematic review

Ethnopharmacological studies in 21st century Brazil: a systematic review

Persea americana Mill. crude extract exhibits antinociceptive effect on UVB radiation-induced skin injury in mice

Inhibitory effect of hydroalcoholic extract of Cunila spicata Benth. on phlogistic agents-induced cellular migration in the airways of mice

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