Antiendomysium antibodies in brazilian patients with celiac disease and their first-degree relatives

Lm, Kotze; Utiyama,; Rm, Nisihara; Mp, Zeni; Mg, de Sena; Hm, Amarante

doi:10.1590/s0004-28032001000200004

Cited by 27 publications

(28 citation statements)

References 53 publications

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“…The prevalence of CD in first-degree relatives of patients with CD undergoing intestinal biopsy varies from 5.5% [29] to 22.5% [30] . In a previous study with 115 Brazilian relatives, we reported 15.6% CD prevalence [5] , with female preponderance, and in the present study there was 3.8% of test positivity (Table 2) [31] . All were female: 1 sister and 1 daughter of the same family; 1 mother.…”

Section: Discussionsupporting

confidence: 71%

“…The first-degree relatives of the patients were invited to participate in the study by phone call [5] . Patients with clinical complaints suggestive of CD were submitted to the point-of-care test and to intestinal biopsy plus IgA EmA determination for comparison [18] .…”

Section: Issn 1007-9327 Cn 14-1219/r World J Gastroenterol September mentioning

confidence: 99%

“…As CD is a disorder that can be r uled out in the differential diagnosis of several gastrointestinal diseases, non-invasive tests are recommended as a first-step to screening patients before small intestinal biopsy to confirm CD [1,4] . Also, gluten-triggered tissue autoantibodies can be determined to aid in monitoring the diet and for case findings of CD in at-risk groups such as relatives [5] and in patients with other autoimmune diseases [6][7][8] . The conventional tests, EMA deter mined by indirect immunofluorescence and anti-tTG performed by ELISA, require sera samples, are laborious and time-consuming, need special laboratorial centers, are expensive and the results are available only after a time lag.…”

Section: Introductionmentioning

confidence: 99%

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A Brazilian experience of the self transglutaminase-based test for celiac disease case finding and diet monitoring

Kotze¹,

Rodrigues²,

Kotze³

et al. 2009

WJG

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AIM:To evaluate the effectiveness of a rapid and easy fingertip whole blood point-of-care test for celiac disease (CD) case finding and diet monitoring. METHODS:Three hundred individuals, 206 females (68.7%) and 94 males (31.3%), were submitted to a rapid and easy immunoglobulin-A-class fingertip whole blood point-of-care test in the doctor's office in order to make immediate clinical decisions: 13 healthy controls, 6 with CD suspicion, 46 treated celiacs, 84 relatives of the celiac patients, 69 patients with dyspepsia, 64 with irritable bowel syndrome (IBS), 8 with Crohn's disease and 9 with other causes of diarrhea. RESULTS:Upper gastrointestinal endoscopy with duodenal biopsies was performed in patients with CD suspicion and in individuals with positive test outcome: in 83.3% (5/6) of the patients with CD suspicion, in 100% of the patients that admitted gluten-free diet transgressions (6/6), in 3.8% of first-degree relatives (3/79) and in 2.9% of patients with dyspepsia (2/69). In all these individuals duodenal biopsies confirmed CD (Marsh's histological classification). The studied test showed good correlation with serologic antibodies, endoscopic and histological findings. CONCLUSION:The point-of-care test was as reliable as conventional serological tests in detecting CD cases and in CD diet monitoring.

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Section: Discussionsupporting

confidence: 71%

Section: Issn 1007-9327 Cn 14-1219/r World J Gastroenterol September mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Brazilian experience of the self transglutaminase-based test for celiac disease case finding and diet monitoring

Kotze¹,

Rodrigues²,

Kotze³

et al. 2009

WJG

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“…The disease may present a wide clinical spectrum, from malabsorption syndrome to extra-intestinal presentations, and can be atypical or asymptomatic (25,74) . Serologic tests are useful for screening and histological abnormalities confirm the diagnosis (38,74) . CD is associated with autoimmune disorders and can cause complications and death.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease in Brazilian patients: associations, complications and causes of death. Forty years of clinical experience

Kotze

2009

Arq. Gastroenterol.

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-Context -Celiac disease is a multisystem auto-immune disorder and may start at any age in genetically predisposed individuals. Objective -To identify associations, complications, and cause of death in Brazilian patients. Methods -One hundred and fifty-seven patients were studied: 23 adolescents and 134 adults, 79.6% females, 20.4% males, 75.8% at the time of diagnosis and 24.2% on a gluten-free diet, follow-up between 1 and 40 years. The diagnosis of celiac disease was based on histologic findings and the presence of serologic auto-antibodies markers for celiac disease. Specific tests were done according to clinical suspicion of associations. Bone mineral density was determined by dual energy x-rays in 53 patients upon diagnosis. The data regarding associations, complications, and causes of death were obtained by interviews and from the patient's charts. -Results -Associations: atopy (22.3%), depression (17.2%), thyroid disorder (15.9%), dermatitis herpetiformis (11.5%), diabetes mellitus types 1 and 2 (4.5%) and tumors (4.5%). Complications -Anemia and osteopenia/osteoporosis in all groups; increased number of spontaneous abortion. Four patients (4.5%) died (one from lymphoma, one with diabetes type 1, one from acute meningitis and one due to suicide). Conclusions -This experience is similar to those described in the world literature. Celiac disease presents the same characteristics independently of the geographic region. We recommend periodic evaluations, from childhood, independent of the duration of the diet. The key is to establish an interval between evaluations. HEADINGS -Celiac disease. Gluten. Lymphoma, non-Hodgkin.

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“…The first, by NUNES et al (24) disclosed a prevalence of 0.8% among a group of 121 relatives. The main focus of the second study, by KOTZE et al (16) was to determine specificity and sensitivity of the antiendomysium antibody test performed on cryostatic sections of human umbilical cord, in a group of confirmed celiac patients and their first-degree relatives. Among the 18 serological positive first-degree relatives seven agreed to underwent intestinal biopsy.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of celiac disease among first degree relatives of Brazilian celiac patients

Almeida

Gandolfi

Modelli

et al. 2008

Arq. Gastroenterol.

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Antiendomysium antibodies in brazilian patients with celiac disease and their first-degree relatives

Abstract: -Background -Literature data have shown high specificity of antiendomysial antibodies (EmA IgA)

Cited by 27 publications

References 53 publications

A Brazilian experience of the self transglutaminase-based test for celiac disease case finding and diet monitoring

A Brazilian experience of the self transglutaminase-based test for celiac disease case finding and diet monitoring

Celiac disease in Brazilian patients: associations, complications and causes of death. Forty years of clinical experience

Prevalence of celiac disease among first degree relatives of Brazilian celiac patients

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