Antiepileptic Rectal Hydrogel Loaded With Carbamazepine – Rice Bran Wax Microspheres

Nair, Sreeja C.; Krishnapriya, M.; Ramesh, Karthika

doi:10.22159/ajpcr.2017.v10i3.16144

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…Thus, apart from existing strategies, additional methods are needed to confine the drug delivery to diseased region. 97 Nano drug delivery system based on positive chargemucoadhesive Nanoparticles coated with positive charge attract to mucosal surface in the inflamed region due to interaction of positively charged nanoparticle and negatively charged mucosal layer. 98 Mucins present in colon are negatively charged because of presence of sulfates and scales acid in the carbohydrates.…”

Section: Nanodrug Delivery System Based On Sizementioning

confidence: 99%

Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery

2019

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An ideal colon specific drug delivery system needs to perform multiple functions like greater bio availability, less toxicity and higher therapeutic efficacy, all of which require high degree of smartness. This article focuses on the overview of the stimuli-responsive polymers and various nanodrug delivery systems which have found applications in colon specific delivery of drugs as this system provide a link between therapeutic need and drug delivery. These polymers exhibit a non-linear response to a small stimulus leading to a macroscopic alteration in their structure/properties. Stimuli responsive polymers display a significant physio chemical change in response to small changes in their environment (temperature, pH, light etc.). Colonic drug delivery has gained increased importance in treating diseases like Crohn’s disease, ulcerative colitis, colon cancer etc. The expansion in the development of polymers based system with greater flexibility, versatility and unexplored potential enables new opportunities for them in uplifting bio medicine. Applying the concepts of smartness in the context of clinically relevant therapeutic and diagnostic systems, it can prelude in a new era of ‘smart’ therapeutics that can improve the health care fields. In particular, due to its high sensitivity to the stimuli, this system has been identified as a sensible platform for releasing drug at suitable site and at appropriate time.

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Section: Nanodrug Delivery System Based On Sizementioning

confidence: 99%

Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery

2019

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Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Zhao,

Ngai,

Wang

et al. 2024

Small Structures

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The treatment of neurological disease, such as epilepsy is rather complicated. Emerging therapies such as surgery, gene therapy, stem cell transplantation, and neurostimulation have been developed to replace traditional drug therapy. However, great challenges such as the difficult localization of epileptic foci (EF), incomplete excision of lesioned nerves, high drug resistance, and severe side effects limit their clinical applications. As an alternative, bioinorganic materials have been emerged and show great potentials for epilepsy theranostics. Their unique physical properties, including fluorescence, magnetic resonance effect, and surface‐enhanced Raman scattering effect (SERS), give them the ability to image the localization of EF. In addition, the fluorescence and conductivity of bioinorganic materials could be further used for studying pathogenesis. Moreover, bioinorganic materials could serve as intelligent systems to deliver drugs and cooperative therapy for epilepsy. Herein, this review highlights the design and application of bioinorganic materials in the imaging, diagnosis, and therapy of epilepsy. Furthermore, light is shown on the potential bottlenecks and future perspectives of bioinorganic materials in epilepsy theranostics.

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