Antiestrogenic Activities of 3,8-Dihydroxy-6,11-dihydrobenzo[a]carbazoles with Sulfur-Containing Side Chains

We herein describe a facile and versatile synthetic route to the tetracyclic system of 6-substituted 5,6-dihydro-11H-pyrido[3,2-i]-1-azacarbazoles with promising anticancer properties. These derivatives are built up by an elegant one-step base-catalyzed synthetic procedure from commercially available building blocks. One additional step provides the corresponding skeleton hitherto unknown in the literature. The possibility to synthesize a large library of compounds with various substitution patterns utilizing this method underlines the importance of this synthetic procedure.

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Triggering the Directional Selectivity of a Ring‐Closure Reaction Leads to Pyridoazacarbazoles with Anticancer Properties

Steinhauer

Längle

Meier

et al. 2015

Chemistry A European J

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Synthesis and Cytotoxicity Studies of Cyclohepta[b]indoles, Benzo[6,7]Cyclohepta[1,2-b]Indoles, Indeno[1,2-b]Indoles, and Benzo[a]Carbazoles

Hong

Jiang

Chang

et al. 2006

Jnl Chinese Chemical Soc

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Synthesis of Novel Indolo‐Spirocyclic Compounds

Sayed

Mahmoud

Hilgeroth

et al. 2015

Journal of Heterocyclic Chem

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In the present work, we succeeded to synthesize the novel indolo‐spirocyclic compounds (4, 5, 6, 7 and 11) via electrophilic condensation reactions of indoles with carbonyl compounds including different types of ketones, for example, heteroacetyl ketones (3‐acetylindole and 3‐acetylpyridine), cyclohexanone, isatin, cyclohexane‐1,4‐dione, whereas an attempt to prepare the spirocyclic 9 failed. This new idea will open a high prospective for continuous investigations related to the synthesis of novel indolo‐spirocyclic compounds.

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Antiestrogenic Activities of 3,8-Dihydroxy-6,11-dihydrobenzo[a]carbazoles with Sulfur-Containing Side Chains

Cited by 10 publications

References 18 publications

Triggering the Directional Selectivity of a Ring‐Closure Reaction Leads to Pyridoazacarbazoles with Anticancer Properties

Triggering the Directional Selectivity of a Ring‐Closure Reaction Leads to Pyridoazacarbazoles with Anticancer Properties

Synthesis and Cytotoxicity Studies of Cyclohepta[b]indoles, Benzo[6,7]Cyclohepta[1,2-b]Indoles, Indeno[1,2-b]Indoles, and Benzo[a]Carbazoles

Synthesis of Novel Indolo‐Spirocyclic Compounds

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