Antifertility Activity of Ethanol Leaf Extract of Moringa oleifera Lam in Female Wistar Rats

Agrawal, S. S.; Dubey, Vishal; Sumeet, G.; Shekhar, Chander; Ashish, N.; Parul, D.; Ankita, Sable; Prakash, Anu; Prakash, Tanu; Kumar, Pramod; Varun, Sood

doi:10.4172/pharmaceutical-sciences.1000394

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…The basal diet consisted of wheat, corn, rice bran, soybean meal, sugarcane molasses, and minerals formulated to fulfill the nutritional requirements of the goats (19) as shown in Table 1. The feeding levels were adjusted according to the previous studies conducted on mice with some modification in the goats (17,20). The does were offered free pasture (Chloris gayana, Carduus nutans, Leptochloa fusca, Cirsium arvense, and Chenopodium album) grazing two times during the morning and evening schedule and were provided free access to clean drinking water.…”

Section: Study Design and Animal Managementmentioning

confidence: 99%

Moringa oleifera Supplementation Improves Antioxidant Status and Biochemical Indices by Attenuating Early Pregnancy Stress in Beetal Goats

2021

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This study investigated the effects of supplementing different levels of Moringa oleifera leaf powder (MOLP) on antioxidant status and blood biochemical indices during early gestation in Beetal goats. A total of 30 goats were randomly divided into three groups (n = 10) comprising control (basal diet without MOLP), the 1.6% MOLP supplemented group (basal diet + 1.6% MOLP), and the 3.2% MOLP supplemented group (basal diet + 3.2% MOLP). The experiment started 5 days before estrus synchronization and lasted till day 60 of gestation. The MOLP significantly increased plasma flavonoids in 1.6% as well as 3.2% supplemented group on days 40 and 60 of pregnancy, while total phenolic contents were observed to be higher in the 3.2% MOLP supplemented group throughout the experiment in comparison with the control group. The supplementation improved plasma total antioxidant capacity (TAC) by decreasing malondialdehyde (MDA) and total oxidant status (TOS) in contrast to the control group. The activities of superoxide dismutase (SOD) and peroxidase (POD) were enhanced in both supplemented groups, whereas catalase (CAT) activity was noticed to be significantly high in the 3.2% MOLP supplemented group. The protein contents were significantly elevated with 1.6 and 3.2% supplementation levels from day 40 to day 60 of the experiment. Plasma sugar level, carotenoids, progesterone profile, and hydrolytic (protease and amylase) enzymes activities were improved only when supplemented with 3.2% MOLP. The findings suggest that supplementing with 3.2% MOLP provides beneficial effects on early pregnancy stress in Beetal goats.

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Section: Study Design and Animal Managementmentioning

confidence: 99%

Moringa oleifera Supplementation Improves Antioxidant Status and Biochemical Indices by Attenuating Early Pregnancy Stress in Beetal Goats

2021

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“…Women have traditionally utilized medicinal plants to aid childbirth, promote menstrual flow, and limit fertility (Agrawal et al, 2018). M. oleifera is well-known for its therapeutic benefits.…”

Section: Antifertility Activitymentioning

confidence: 99%

Phytochemistry, nutritional composition and pharmacological potential of Moringa oleifera: A comprehensive review

Adusei¹,

Azupio

Tei

2022

ijpbp

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Moringa oleifera is a medicinally important plant of the family Moringaceae, which is highly valued because of its enormous nutritional and therapeutic potential. Each part of M. oleifera is said to contain medicinal properties, which contributes to its diversity and value as a medicinal herb. Literature has revealed that the plant possesses anticancer, antimicrobial, anti-inflammatory, antidiabetic, antifertility, hepatoprotective, cardiovascular, and other important pharmacological attributes. Most of these biological activities of the plant are due to its high content of phytochemicals, including flavonoids, alkaloids, saponins, terpenes, glucosides, glucosinolates, anthocyanins, and steroids. Aside from the plant's exceptional phytochemicals and therapeutic potentials, it is also rich in essential nutrients such as vitamins, minerals, proteins, betacarotene, fiber, and fatty acids. This systematic review aims at providing updated and categorized scientific data on phytochemicals, nutritional composition, and pharmacological potentials of M. oleifera. The information compiled in this present review would be crucial for developing novel therapeutic medicines and pharmaceutical formulations, which are more effective with great curative actions.

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“…Furthermore, artificial decidualization studies revealed dose-dependent reductions in weight gain, oestradiol levels, and progesterone levels, which led to reduced expression of various local cytokines, include cyclooxygenase-2, leukaemia inhibitory factor, vascular endothelial growth factor, and interleukin 11, as demonstrated by immunohistochemistry and reverse transcription polymerase chain reaction studies. Moringa oleifera ethanol extract at doses of 250 and 500 mg/kg inhibited implantation in female rats, indicating that it has an antifertility effect and should be investigated further for potential contraceptive action 46 .…”

Section: Wound Healing Activitymentioning

confidence: 99%

Untitled

2022

IJPSR

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Moringa oleifera is an angiosperm plant that belongs to the family Moringaceae. It is also known as the Drumstick tree or Horseradish tree. Alkaloids, protein, quinine, saponins, flavonoids, tannin, steroids, glycosides, fixed oil and lipids are among the active phytoconstituents present. It is distributed throughout the world's tropical and subtropical regions. Several studies show that various parts of the plant, such as seeds, flowers, bark, fruits, pods, gum and leaves, have antitumor, antiinflammatory, wound healing, cholesterol-lowering, antioxidant, antidiabetic, antibacterial and antifungal, antimicrobial, antiulcer, antifibrotic, antifertility, antiurolithiatic, anticonvulsant, analgesic, local anesthetic, antiasthmatic and are used in the indigenous system of medicine to treat various diseases. This review aims to provide complete data, including morphology, cultivation and propagation, distribution, phytochemistry, traditional uses & Pharmacological activities. INTRODUCTION:Moringa oleifera is commonly known as 'drumstick tree' or 'horseradish tree' belonging to the family of Moringaceae 1 . It belongs to the genus Moringa having 13 different species. The most widely grown of them is Moringa oleifera, which is native to tropical and subtropical regions of the world 2 . The tree reaches a height of 5-10 m and can be found wild and cultivated across the plains, especially in hedges and house yards. It grows best in an insular tropical environment and is widespread near river and stream sandy beds 3 . Alkaloids, protein, quinine, saponins, flavonoids, tannin, steroids, glycosides, fixed oil and fat and other active phytoconstituents have been found in this plant through phytochemical studies 4 .

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Antifertility Activity of Ethanol Leaf Extract of Moringa oleifera Lam in Female Wistar Rats

Cited by 8 publications

References 6 publications

Moringa oleifera Supplementation Improves Antioxidant Status and Biochemical Indices by Attenuating Early Pregnancy Stress in Beetal Goats

Moringa oleifera Supplementation Improves Antioxidant Status and Biochemical Indices by Attenuating Early Pregnancy Stress in Beetal Goats

Phytochemistry, nutritional composition and pharmacological potential of Moringa oleifera: A comprehensive review

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