Antifertility effects of the intrauterine foreign body

Sahwi, Samir El; Moyer, Dean L.

doi:10.1016/0010-7824(70)90010-7

Cited by 50 publications

(5 citation statements)

References 103 publications

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“…Despite this privileged immune status, some biomaterial foreign bodies are known to provoke an immune response in the uterus. In fact, the contraceptive mechanism of intrauterine devices (IUDs) is due in part to inflammation generated towards a foreign body [ [31] , [32] , [33] , [34] ]. Although IUDs provoke an immune response, these devices are not subject to fibrous capsule formation and can be readily removed [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of tissue microenvironment on fibrous capsule formation to biomaterial-coated implants

et al. 2021

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Within tissue exposed to the systemic immune system, lymphocytes and fibroblasts act against biomaterials via the development of a fibrous capsule, known as the foreign body reaction (FBR). Inspired by the natural tolerance that the uterine cavity has to foreign bodies, our study explores the role of microenvironment across classical (subcutaneous) and immune privileged (uterine) tissues in the development of the FBR. As a model biomaterial, we used electrospun fibers loaded with sclerosing agents to provoke scar tissue growth. Additionally, we integrated these materials onto an intrauterine device as a platform for intrauterine biomaterial studies. Polyester materials in vitro achieved drug release up to 10 days, greater pro-inflammatory and pro-healing cytokine expression, and the addition of gelatin enabled greater fibroblast attachment. We observed the materials that induced the greatest FBR in the mouse, had no effect when inserted at the utero-tubal junction of non-human primates. These results suggest that the FBR varies across different tissue microenvironments, and a dampened fibrotic response exists in the uterine cavity, possibly due to immune privilege. Further study of immune privileged tissue factors on biomaterials could broaden our understanding of the FBR and inform new methods for achieving biocompatibility in vivo .

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Section: Introductionmentioning

confidence: 99%

Effect of tissue microenvironment on fibrous capsule formation to biomaterial-coated implants

et al. 2021

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“…Many studies suggest that the anti-fertility effects are mediated by the consistently observed influx of polymorphonuclear leucocytes (PMNL) into the uterus resulting from the inflam¬ matory stimulus of the IUD. It has been claimed that fertility is inversely related to the surface area of the IUD in contact with the uterine endometrium (Davis & Lesinski, 1970) and to the number of PMNL cells present (El Sahwi & Moyer, 1970).…”

Section: Introductionmentioning

confidence: 99%

Glycogen-induced intrauterine leucocytosis and its effect on mouse blastocyst implantation in vivo and in vitro

Waites¹,

Bae²

1982

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“…Marston, Kelly & Eckstein, 1969;El Sahwi & Moyer, 1970;Eckstein, 1972). It may be, however, that they also cause an accumula¬ tion of phagocytic cells in the uterine lumen, as a result of which the number of viable spermatozoa reaching the Fallopian tube is critically reduced.…”

Section: Metrium Of Baboons Without Iudsmentioning

confidence: 94%