Antifouling Stripes Prepared from Clickable Zwitterionic Copolymers

Sae‐ung, Pornpen; Kolewe, Kristopher W.; Bai, Ying; Rice, Eric W.; Schiffman, Jessica D.; Emrick, Todd; Hoven, Voravee P.

doi:10.1021/acs.langmuir.7b01431

Cited by 30 publications

(29 citation statements)

References 36 publications

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“…To visualize the MPC polymer on the substrate, rhodamine 6G is generally used as a fluorescence dye . Figure shows the fluorescence images of the PMBPAz‐immobilized PMMA substrates stained with rhodamine.…”

Section: Resultsmentioning

confidence: 99%

Reliable surface modification of dental plastic substrates to reduce biofouling with a photoreactive phospholipid polymer

Ishihara

Fukazawa

Inoue

et al. 2018

J of Applied Polymer Sci

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Plastic substrates have been widely applied in clinical settings for dental treatments. These substrates should be strong enough for long‐term implantation in the oral cavity and should be resistant to biofouling. We developed a new photoreactive phospholipid polymer to reduce biofouling on dental plastics via a photochemical reaction. Poly(methyl methacrylate) (PMMA) and poly(ether ether ketone) (PEEK) were used as dental plastics. To determine the antibiofouling properties on the polymer surface, the phospholipid polymer was covalently immobilized on the substrates by UV irradiation. We evaluated the antibiofouling properties by observing the protein adsorption and cell and bacterial adhesion. Significant protein adsorption and cell adhesion appeared on the bare PMMA and PEEK substrates but decreased dramatically after surface modification with the phospholipid polymer. Thus, this photoreactive polymer shows potential for conferring dental plastics with antibiofouling properties. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46512.

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Section: Resultsmentioning

confidence: 99%

Reliable surface modification of dental plastic substrates to reduce biofouling with a photoreactive phospholipid polymer

Ishihara

Fukazawa

Inoue

et al. 2018

J of Applied Polymer Sci

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“…Firstly, poly(MPC‐DHLA) was synthesized as previously reported via a controlled RAFT polymerization in TFE using ACVA as the radical initiator and CPD as the chain transfer agent. The target degree of polymerization and copolymer composition (MPC: DHLA) were set at 100 and 70:30, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…A random copolymer of MPC and DHLA was synthesized in three steps as previously reported . The monomer based on HEMA conjugated with LA (HEMA‐LA) was first synthesized via carbodiimide coupling.…”

Section: Methodsmentioning

confidence: 99%

“…In this research, seven biomedically relevant substrates composed of three inorganic substrates (Si, Ti, and SUS) and four organic substrates (PDMS, PE, PMMA, and PEEK) were chosen for universal coating. All substrates were cut into a square shape (1.2 × 1.2 cm 2 ) and poly(MPC‐DHLA) film was spin‐coated onto all substrates as previously reported with slight modifications.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, a straightforward method for antifouling coating onto silicon (Si) substrates using copolymers of 2‐methacryloyloxyethyl phosphorylcholine (MPC) and a methacrylate‐substituted dihydrolipoic acid (DHLA) (poly(MPC‐DHLA)) was reported . The MPC units provided the antifouling property and the DHLA units enabled cross‐linking via thiol‐ene reactions in the presence of multifunctional alkenes to achieve the robust thin films.…”

Section: Introductionmentioning

confidence: 99%

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Clickable Zwitterionic Copolymer as a Universal Biofilm‐Resistant Coating

Sae‐ung

Wijitamornloet

Iwasaki

et al. 2019

Macro Materials & Eng

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Hospital‐acquired infections are often caused by bacterial biofilms on medical devices. To prevent biofilm formation, herein, a universal coating of an antifouling polymer that inhibits the initial adhesion of bacteria is developed. This copolymer is made of methacryloyloxyethyl phosphorylcholine (MPC) and a methacrylate‐substituted dihydrolipoic acid (DHLA) (poly(MPC‐DHLA)). The MPC units provide the antifouling property, while the DHLA units offer cross‐linkable sites via thiol‐ene reactions to form the stable coated copolymer film. Without the requirement for covalent surface grafting, the poly(MPC‐DHLA) coating on various biomedically relevant substrates is investigated, where X‐ray photoelectron spectroscopy, water contact angle measurements, atomic force microscopy, and ellipsometry are used to confirm the success of the surface coating. Moreover, to mimic an actual clinical use, the copolymer coating is applied on a titanium dental substrate and the ability to inhibit biofilm formation by Staphylococcus aureus is quantified and visualized by crystal violet staining and scanning electron microscopy, respectively. As compared with the bare substrate, an effective reduction in bacterial adhesion and suppression of the subsequent biofilm formation is observed on the copolymer‐modified substrate. These features are maintained for up to 7 d indicating the durability as well as universal applicability of this coating approach.

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Strategies toward development of antimicrobial biomaterials for dental healthcare applications

Parhi

Pal

Das

et al. 2021

Biotech & Bioengineering

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Several approaches for elimination of oral pathogens are being explored at the present time since oral diseases remain prevalent affecting approximately 3.5 billion people worldwide. Need for antimicrobial biomaterials in dental healthcare include but is not restricted to designing resin composites and adhesives for prevention of dental caries. Constant efforts are also being made to develop antimicrobial strategies for clearance of endodontic space prior root canal treatment and for treatment of periimplantitis and periodontitis. This article discusses various conventional | © 2021 Wiley Periodicals LLC Microorganisms Type of disease References Lactobacilli Dental caries Caufield et al. (2015) (Mutans streptococci) Streptococcus mutans, Streptococcus sorbinus Dianawati et al. (2020) Aggregatibacter actinomycetemcomitans Periodontitis Oscarsson et al. (2019) Porphyromonas gingivalis Z. He et al. (2020) Fusobacterium nucleatum Endodontic infection Martinho et al. (2016); Matsui et al. (2014) Enterococcus faecalis Alghamdi and Shakir (2020)

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Antifouling Stripes Prepared from Clickable Zwitterionic Copolymers

Cited by 30 publications

References 36 publications

Reliable surface modification of dental plastic substrates to reduce biofouling with a photoreactive phospholipid polymer

Reliable surface modification of dental plastic substrates to reduce biofouling with a photoreactive phospholipid polymer

Clickable Zwitterionic Copolymer as a Universal Biofilm‐Resistant Coating

Strategies toward development of antimicrobial biomaterials for dental healthcare applications

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