Antifungal activity of 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action

Soberón, José Rodolfo; Lizarraga, Emilio Fernando; Sgariglia, Melina Araceli; Juarez, Marisa B. Carrasco; Sampietro, Diego Alejandro; Altabef, A. Ben; Catalán, César A.N.; Vattuone, Marta Amelia

doi:10.1007/s10482-015-0559-3

Cited by 12 publications

(9 citation statements)

References 28 publications

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“…The closely-related compounds furfuryl alcohol and acetyl furan, as well as three of the six phenyl-ketones tested also performed well against P. infestans germination. Acetophenone derivatives are well-described antifungals thought to target the fungal cell wall (Soberon et al, 2015 ; De Aguiar et al, 2016 ). A high level of inhibition also resulted from exposure to diphenylamine and 2,5-dimethylpyrazine treatments; however we cautiously consider these compounds as artifacts originating from the medium.…”

Section: A Pharmacological Approach To Exploring Volatile Potentialmentioning

confidence: 99%

Mining the Volatilomes of Plant-Associated Microbiota for New Biocontrol Solutions

Bailly

Weisskopf

2017

Front. Microbiol.

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Microbial lifeforms associated with land plants represent a rich source for crop growth- and health-promoting microorganisms and biocontrol agents. Volatile organic compounds (VOCs) produced by the plant microbiota have been demonstrated to elicit plant defenses and inhibit the growth and development of numerous plant pathogens. Therefore, these molecules are prospective alternatives to synthetic pesticides and the determination of their bioactivities against plant threats could contribute to the development of control strategies for sustainable agriculture. In our previous study we investigated the inhibitory impact of volatiles emitted by Pseudomonas species isolated from a potato field against the late blight-causing agent Phytophthora infestans. Besides the well-documented emission of hydrogen cyanide, other Pseudomonas VOCs impeded P. infestans mycelial growth and sporangia germination. Current advances in the field support the emerging concept that the microbial volatilome contains unexploited, eco-friendly chemical resources that could help select for efficient biocontrol strategies and lead to a greener chemical disease management in the field.

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Section: A Pharmacological Approach To Exploring Volatile Potentialmentioning

confidence: 99%

Mining the Volatilomes of Plant-Associated Microbiota for New Biocontrol Solutions

Bailly

Weisskopf

2017

Front. Microbiol.

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“…Apesar de ainda não haver dados sobre a atividade antifúngica do EPHO, outras moléculas da classe das acetofenonas e derivados já demonstraram atividade contra diferentes fungos, incluindo C. albicans, sugerindo também que sua ação farmacológica provavelmente ocorra devido a inibição da formação da parede celular fúngica além de impedir o desenvolvimento de estruturas de virulência como pseudohifas [19,32].…”

Section: Resultsunclassified

Estudo de atividade antimicrobiana de 3,4-(metilenodióxi)-acetofenona

et al. 2020

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A crescente incidência de infecções por bactérias e fungos têm preocupado diversos órgãos de saúde ao redor do mundo. Entre as infecções mais prevalentes estão as bacterianas, causadas por Staphylococcus aureus e Pseudomonas aeruginosa, e infecções fúngicas como candidíase e aspergilose. A farmacoterapia utilizada nos casos de infecção normalmente apresenta toxicidade indesejada e hoje em dia já começa a falhar ao não obter êxito diante de cepas resistentes. Esta realidade gera a necessidade crítica de desenvolvimento de novas estratégias para o combate destas infecções de elevadas taxas de mortalidade. A 3,4-(metilenodióxi)-acetofenona (EPHO) é um produto químico da classe das acetofenonas, facilmente adquirido comercialmente e amplamente utilizado em reações de síntese química. Contudo, ainda não é apropriadamente explorada quanto ao seu potencial antimicrobiano. Para avaliar o perfil antimicrobiano da substância, a concentração inibitória mínima (CIM) foi determinada contra cepas bacterianas e fúngicas envolvendo tanto leveduras quanto fungos filamentosos. Foi observado que, apesar do produto se mostrar inerte contra bactérias, ele apresentou atividade inibitória contra algumas cepas de fungos leveduriformes e filamentosos com CIM respectivas de 1024 e 512 µg/mL.

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“…For example, Candida albicans and Aspergillus fumigatus are opportunistic fungi. These fungi can produce invasive fungal infections in any organ of humans [3]. Limited numbers of therapeutic antifungal agents are available for these fungi because of increased resistance mechanisms through the biofilms' formation by the fungal strains [2].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antifungal Activity of the Extracts of Different Parts of Avicennia marina (Forssk.) Vierh

Okla

Alatar

Al-amri

et al. 2021

Plants

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Increased problems associated with side effects and bacterial resistance of chemical drugs has prompted the research focus on herbal medicines in the past few decades. In the present investigation, the antimicrobial activity of the various parts of Avicennia marina (AM), a mangrove plant, has been evaluated. The plants were collected from the Jazan area of the Kingdom of Saudi Arabia. Primary extracts of roots, stem, leaves, fruits, and seeds were made in ethanol and fractioned in ethanol, ethyl acetate, petroleum ether, chloroform, and water. Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the extracts were determined against Bacillussubtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. It has been observed that the chloroform extract of roots of the AM exhibited inhibitory effects against both S. aureus (MIC = 1.5 ± 0.03 mg/mL) and E. coli (MIC = 1.7 ± 0.01 mg/mL). The ethanolic extract of the AM roots has shown antibacterial activity against Pseudomonas aeruginosa (MIC = 10.8 ± 0.78 mg/mL), Bacillussubtilis (MIC = 6.1 ± 0.27 mg/mL), Staphylococcus aureus (MIC = 2.3 ± 0.08 mg/mL), and Escherichia coli (MIC = 6.3 ± 0.28 mg/mL). The leaf extract of the AM in ethyl acetate showed antibacterial activity against S. aureus and E. coli. Antifungal activity of these extracts was also investigated against Aspergillus fumigatus and Candida albicans. Ethanolic extract of roots and seeds of the AM has shown antifungal activity against Aspergillus fumigatus when applied individually. Ethanolic extract of the AM fruits has shown an inhibitory effect on the growth of Aspergillus fumigatus and Candida albicans. It is suggested that the plant extracts of AM have tremendous antimicrobial activity against a group of microbes, and this effect depends on both the plant part and the solvent used for extraction. Therefore, this plant can be considered to treat various diseases caused by antibiotic-resistant bacteria.

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Antifungal activity of 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action

Cited by 12 publications

References 28 publications

Mining the Volatilomes of Plant-Associated Microbiota for New Biocontrol Solutions

Mining the Volatilomes of Plant-Associated Microbiota for New Biocontrol Solutions

Estudo de atividade antimicrobiana de 3,4-(metilenodióxi)-acetofenona

Antibacterial and Antifungal Activity of the Extracts of Different Parts of Avicennia marina (Forssk.) Vierh

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