Antifungal activity of gold nanoparticles prepared by solvothermal method

Ahmad, Tokeer; Wani, Irshad A.; Lone, Irfan H.; Ganguly, Anirban; Manzoor, Nikhat; Ahmad, Aijaz; Ahmed, Jahangeer; Al-Shihri, Ayed S.

doi:10.1016/j.materresbull.2012.09.069

Cited by 144 publications

(53 citation statements)

References 63 publications

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“…5). The broccoli-synthesized AuNps were highly efficient and have the high level of antifungal activity compared to the previous report of green synthesis gold nanoparticles from different sources (Geethalakshmi and Sarada 2013;Ahmad et al 2013). The antimicrobial ability of AuNPs might be referred to their small size (12-22 nm), which is 2759 smaller than a bacterium.…”

Section: Discussionmentioning

confidence: 76%

Gold nanoparticles synthesized by Brassica oleracea (Broccoli) acting as antimicrobial agents against human pathogenic bacteria and fungi

Piruthiviraj

Margret²,

Krishnamurthy

2015

Appl Nanosci

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Production of antimicrobial agents through the synthesis of gold nanoparticles using green technology has been extensively made consistent by various researchers; yet, this study uses the flower bud's aqueous extracts of Brassica oleracea (Broccoli) as a reducing agent for chloroauric acid (1 mM). After 30 min of incubation, synthesis of gold nanoparticles (AuNps) was observed by a change in extract color from pale yellow to purple color. Synthesis of AuNps was confirmed in UV-visible spectroscopy at the range of approximately 560 nm. The SEM analysis showed the average nanoparticles size of 12-22 nm. The antimicrobial activity of AuNps was analyzed by subjecting it to human pathogenic bacteria (Grampositive Staphylococcus aureus and Gram-negative Klebsiella pneumonia) and fungi (Aspergillus flavus, Aspergillus niger and Candida albicans) using disc diffusion method. The broccoli-synthesized AuNps showed the efficient antibacterial and antifungal activity of above-mentioned microbes. It was confirmed that AuNps have the best antimicrobial agent compared to the standard antibiotics (Gentamicin and Fluconazole). When the concentrations of AuNps were increased (10, 25, and 50 lg/ml), the sensitivity zone also increased for all the tested microbes. The synthesized AuNps are capable of rendering high antimicrobial efficacy and, hence, have a great potential in the preparation of drugs used against major bacterial and fungal diseases in humans.

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Section: Discussionmentioning

confidence: 76%

Gold nanoparticles synthesized by Brassica oleracea (Broccoli) acting as antimicrobial agents against human pathogenic bacteria and fungi

Piruthiviraj

Margret²,

Krishnamurthy

2015

Appl Nanosci

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“…It has been demonstrated that AuNPs possess antibacterial and antifungal activities [76,80,81], whereas the antimicrobial activity is dependent on the method of synthesis, size, shape, and concentration of the generated NPs [76,81]. The antibacterial and antifungal activities of the AuNPs prepared in this work were evaluated via a zone of inhibition assay.…”

Section: Zone Of Inhibitionmentioning

confidence: 99%

“…In acid, the antimicrobial activity was shown to increase with increasing molecular weight [24], while the antimicrobial activity changed at pH 7.0 [7]. In this study, four different molecular weights of chitosan (80,200, 500, and 1500 kDa) were tested for their antibacterial activities ( Table 1). The 200-kDa chitosan was found to have the lowest minimum inhibitory concentration (MIC) against E. coli ( Figure 1A).…”

Section: Characterzation Of Chitosan and Protaminementioning

confidence: 99%

Antibacterial Activity of Nanomaterials

2018

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“…Apart from these factors, other determinants affecting use of nanoparticles in SERS involve size distribution, surface charge as well as environment surrounding the nanoparticles [17]. Different synthesis approaches like solvothermal [18,19], chemical [20], spray pyrolysis [21,22], electrochemical [23,24], microwave-assisted [25] have been exploited for synthesizing silver as well as gold nanoparticles with different sizes as well as morphologies. Modulation of shape, size, surface area, electrical conductivity, etc of nanoparticles may be achieved via modification of the reaction conditions as well as chemicals used during chemical synthesis [20].…”

Section: Introductionmentioning

confidence: 99%

Gold and silver nanoparticles used for SERS detection of S. aureus and E. coli

Ankamwar

Gharpure

2020

Nano Ex.

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Surface enhanced Raman scattering (SERS) is emerging as a robust analytical method used in sensing applications in chemical as well as biological systems. SERS has been reported to be used in fast detection of micro-organisms up to the specificity of strain identification. However, use of SERS is tricky because of difficulties involved in selection of SERS active substrate so as to give uniform, sensitive as well as reproducible results. We have synthesized silver and gold nanoparticles using chemical, electrochemical and microwave-assisted methods followed by their characterization. Uses of these nanoparticles in association with micro-organisms such as S. aureus and E. coli have been analyzed using SERS to generate signature spectra. This demonstrates use of so synthesized gold and silver nanoparticles as SERS active substrates for rapid detection of micro-organisms which pave way to find applications in disease diagnostics.

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Antifungal activity of gold nanoparticles prepared by solvothermal method

Cited by 144 publications

References 63 publications

Gold nanoparticles synthesized by Brassica oleracea (Broccoli) acting as antimicrobial agents against human pathogenic bacteria and fungi

Gold nanoparticles synthesized by Brassica oleracea (Broccoli) acting as antimicrobial agents against human pathogenic bacteria and fungi

Antibacterial Activity of Nanomaterials

Gold and silver nanoparticles used for SERS detection of S. aureus and E. coli

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