Antifungal Activity of <i>Chromolaena odorata </i>(L.) King & Robinson(Asteraceae) of Cameroon

Abstract

An aqueous ethanol extract of leaves of Chromolaena odorata and some of its fractions were examined for their antifungal properties by dilution methods on solid and liquid media, using yeasts and filamentous fungi. Extract and fractions inhibit the in vitro growth of Cryptococcus neoformans, Microsporum gypseum, Trichophyton mentagrophytes and Trichophyton rubrum with a minimal inhibitory concentration range from 62.5 to 500 µg/ml for the extract and from 25 to 100 µg/ml for fractions. A qualitative chemical analysis of the extract and fractions showed the presence of biologically active constituents such as some coumarins, flavonoids, phenols, tannins and sterols. No toxic effect was observed in mice treated per os with the extract. This study provides a scientific confirmation of the use of Chromolaena odorata in traditional medicine.

A New Flavanone as a Potent Antioxidant Isolated from Chromolaena odorata L. Leaves

“…Recently, C. odorata was described for its beneficial attributes in some Asia-Africa countries, especially the pharmacological effects of this plant. The specific reported attributes of C. odorata include being antibacterial [17], antifungal [18, 19], anti-inflammatory [20, 21], anticancer [11, 13, 22], antiplasmodial [9], antidiabetic [23, 24], and antioxidant [6, 25–28]. However, the antioxidant activity of the isolated compound from C. odorata has never been reported.…”

The medicinal plants of Myanmar

“…No toxic effect was noticed in the mice treated. ( Ngono Ngane et al 2006 ). Ethanol extracts of leaves of this species also showed antibacterial activites, inhibiting the growth of Bacillus subtilis , Staphylococcus aureus , and Salmonella typhimurium .…”

Characterization of the Oxidative Enzyme Potential in Wild White Rot Fungi From Misiones (Argentina)

“…Unsurprisingly, only some fungi are able to grow in tannic acid-containing medium because tannins are usually toxic to microorganisms, mainly due to enzymatic inhibition, substrate deficiency, action on membranes and lack of metal ions (Ngono Ngane et al, 2006). Nevertheless, some fungi, bacteria and yeasts are quite resistant and capable of growing in the presence of tannins making its use justifiable to the screening purpose under stringent conditions (Bhat et al, 2007).…”