Antifungal natural products

Heard, Stephanie C.; Wu, Guangwei; Winter, Jaclyn M.

doi:10.1016/j.copbio.2021.02.001

Cited by 55 publications

(26 citation statements)

References 55 publications

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“…Principalmente devido pequeno arsenal terapêutico antifúngico, além do alto custo total do tratamento, efeitos adversos dos fármacos e aparecimento de cepas resistentes. Isso impulsiona a busca de alternativas a este cenário (Heard et al, 2021) Os valores da CIM e CFM de di-hidrojasmona estão demonstrados na Tabela 1. O terpeno apresentou uma CIM de 128 -256 µg/mL, dependendo da cepa ensaiada, demonstrando, segundo critérios de (Sartoratto et al, 2004) forte atividade antifúngica.…”

Section: Resultsunclassified

Efeito inibitório de di-hidrojasmona frente cepas de Candida spp. fluconazol resistentes

Lima

Silva

Fonseca

et al. 2021

RSD

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Introdução: A candidíase está relacionada a uma grande variedade de manifestações clínicas que se expressam desde infecções na pele e mucosas à infecção sistêmica. Sendo esta última associada a uma alta taxa de mortalidade global, variando de 36% a 63% em diferentes grupos de pacientes. A terapêutica de infecções fúngicas invasivas é limitada pois há apenas três classes de fármacos convencionais utilizados. Diante deste cenário, estratégias de uso racional dos antifúngicos e busca de novas alternativas terapêuticas se fazem necessárias. Objetivo: Avaliar a atividade antifúngica in vitro do monoterpeno di-hidrojasmona frente cepas de Candida albicans e Candida parapsilosis fluconazol resistentes. Metodologia: As concentrações inibitórias mínimas (CIM) e fungicida mínima (CFM) foram determinadas pelo método de microdiluição. Posteriormente foi observado se a ação antifúngica de di-hidrojasmona ocorre via parede celular (ensaio com sorbitol) ou via membrana (ensaio com ergosterol exógeno). Resultados: A di-hidrojasmona apresentou uma CIM entre 128 - 256 µg/mL e a CFM teve os mesmos valores de CIM, respectivamente. No ensaio com ergosterol exógeno, a CIM da di-hidrojasmona aumentou na presença do ergosterol exógeno sugerindo que o mecanismo de ação do monoterpeno ocorre a partir de sua ligação ao ergosterol presente na membrana. Não houve alteração frente ao uso do sorbitol. Conclusão: Baseado nestes resultados, o presente estudo demonstra que di-hidrojasmona possui forte atividade antifúngica e sugere que esta atividade esteja relacionada a sua ligação ao ergosterol da membrana fúngica. Logo, di-hidrojasmona demostra ser um promissor bioproduto na busca de alternativas para o tratamento das candidíases.

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Section: Resultsunclassified

Efeito inibitório de di-hidrojasmona frente cepas de Candida spp. fluconazol resistentes

Lima

Silva

Fonseca

et al. 2021

RSD

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“…As shown in this study, thymoquinone, ocimene, or miramistin-loaded bacterial cellulose wound dressings are promising antifungal hydrogels that could address the aforementioned issues. As shown through the MFC and cytotoxicity assays, these materials could be potentially used in the groups mentioned above owing to the high level of antifungal activity and low cytotoxic effects when compared to conventional antifungal drugs that could exasperate pre-existing conditions, namely amphotericin B [ 70 ].…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

The Mould War: Developing an Armamentarium against Fungal Pathogens Utilising Thymoquinone, Ocimene, and Miramistin within Bacterial Cellulose Matrices

et al. 2021

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An increase in antifungal resistance has seen a surge in fungal wound infections in patients who are immunocompromised resulting from chemotherapy, disease, and burns. Human pathogenic fungi are increasingly becoming resistant to a sparse repertoire of existing antifungal drugs, which has given rise to the need to develop novel treatments for potentially lethal infections. Bacterial cellulose (BC) produced by Gluconacetobacter xylinus has been shown to possess many properties that make it innately useful as a next-generation biopolymer to be utilised as a wound dressing. The current study demonstrates the creation of a pharmacologically active wound dressing by loading antifungal agents into a biopolymer hydrogel to produce a novel wound dressing. Amphotericin B is known to be highly hepatotoxic, which reduces its appeal as an antifungal drug, especially in patients who are immunocompromised. This, coupled with an increase in antifungal resistance, has seen a surge in fungal wound infections in patients who are immunodeficient due to chemotherapy, disease, or injury. Antifungal activity was conducted via Clinical & Laboratory Standards Institute (CLSI) M27, M38, M44, and M51 against Candida auris, Candida albicans, Aspergillus fumigatus, and Aspergillus niger. This study showed that thymoquinone has a comparable antifungal activity to amphotericin B with mean zones of inhibition of 21.425 ± 0.925 mm and 22.53 ± 0.969 mm, respectively. However, the mean survival rate of HEp-2 cells when treated with 50 mg/L amphotericin B was 29.25 ± 0.854% compared to 71.25 ± 1.797% when treated with 50 mg/L thymoquinone. Following cytotoxicity assays against HEp-2 cells, thymoquinone showed a 71.25 ± 3.594% cell survival, whereas amphotericin B had a mean cell survival rate of 29.25 ± 1.708%. The purpose of this study was to compare the efficacy of thymoquinone, ocimene, and miramistin against amphotericin B in the application of novel antifungal dressings.

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“…Invasive aspergillosis usually leads to a severe life-threatening infection, especially for immunocompromised patients [17,18]. Recently, ASP2397 (also known as VL-2397 under clinical trial), a hydroxamate-containing siderophore isolated from fungus Acremonium persicinum, exhibited potent antifungal activities [6,19]. Hydroxamic acids usually possess a formula RC(O)N(OH)R' and can be regard as a type of N-hydroxy amides [20].…”

Section: Structure Elucidation Of Compounds 1-10mentioning

confidence: 99%

Cyclopeptide Derivatives from the Sponge-Derived Fungus Acremonium persicinum F10

2021

Marine Drugs

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Cyclopeptides usually play a pivotal role, either in the viability or virulence of fungi. Two types of cyclopeptides, six new hydroxamate siderophore cyclohexapeptides (1–6), including acremonpeptides E and F, and their complexes with aluminum and ferric ions; one new cyclic pentapeptolide, aselacin D (9); together with a known compound, aselacin C (10), were isolated and characterized from the sponge-derived fungus Acremonium persicinum F10. In addition, two new siderophore analogues chelating gallium ions (Ga3+), Ga (Ⅲ)-acremonpeptide E (7) and Ga (Ⅲ)-acremonpeptide F (8), using isolated acremonpeptides E and F, were prepared. The planar structures of 1–10 were elucidated by HRESIMS and (1D and 2D) NMR. The absolute configurations of amino acids were determined by means of the advanced Marfey’s method and X-ray single-crystal diffraction analysis. X-ray fluorescence (XRF) spectrometer was performed to disclose the elements of compound 1, indicating the existence of aluminum (Al). Al (Ⅲ)-acremonpeptides E (1), Ga (Ⅲ)-acremonpeptides E (5), Al (Ⅲ)-acremonpeptide F (7), and Ga (Ⅲ)-acremonpeptide F (8) displayed high in vitro anti-fungal activities, which are comparable to amphotericin B, against Aspergillus fumigatus and Aspergillus niger.

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Antifungal natural products

Cited by 55 publications

References 55 publications

Efeito inibitório de di-hidrojasmona frente cepas de Candida spp. fluconazol resistentes

Efeito inibitório de di-hidrojasmona frente cepas de Candida spp. fluconazol resistentes

The Mould War: Developing an Armamentarium against Fungal Pathogens Utilising Thymoquinone, Ocimene, and Miramistin within Bacterial Cellulose Matrices

Cyclopeptide Derivatives from the Sponge-Derived Fungus Acremonium persicinum F10

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