Antigenic drift in swine influenza H3 haemagglutinins with implications for vaccination policy

Jong, J.C. de; Nieuwstadt, A. P. van; Kimman, Tjeerd G.; Loeffen, W.L.A.; Bestebroer, Theo M.; Bijlsma, K; Verweij, C.A.; Osterhaus, Albert D. M. E.; Claas, Eric C. J.

doi:10.1016/s0264-410x(98)00392-2

Cited by 53 publications

(34 citation statements)

References 24 publications

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“…Analysis of swine H3N2 viruses in The Netherlands and southern China showed that antigenic drift occurs. Phylogenetic analysis of these viruses, however, showed that swine and human viruses display diverging lines of evolution (12,19). The triple-reassortant variants described in the present study do not form distinct lineages, and thus they appear to have arisen through reassortment rather than through antigenic drift.…”

Section: Discussioncontrasting

confidence: 53%

Evolution of Swine H3N2 Influenza Viruses in the United States

Webby

Swenson²,

Krauss

et al. 2000

J Virol

333

273

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Section: Discussioncontrasting

confidence: 53%

Evolution of Swine H3N2 Influenza Viruses in the United States

Webby

Swenson²,

Krauss

et al. 2000

J Virol

333

273

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“…Sequence analysis of HA genes has shown that antigenic drift does occur in both European H1N1 and H3N2 viruses of swine (Brown et al, 1997;de Jong et al, 1999) raising concerns from some investigators that vaccines in swine may need to be continually updated as in human populations. Heinen et al (2001) nation with A/Port Chalmers/1/73 (H3N2) was sufficient to stop the development of fever and transmission upon challenge with a recent European field strain.…”

Section: Discussionmentioning

confidence: 99%

Multiple lineages of antigenically and genetically diverse influenza A virus co-circulate in the United States swine population

et al. 2004

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“…Several swine H3N2 viruses from Belgium and The Netherlands used in this study have been described previously (8). Additional virus isolates were obtained from respiratory samples of pigs in Italy during the period from 1977 to 1999.…”

Section: Methodsmentioning

confidence: 99%

“…Additional virus isolates were obtained from respiratory samples of pigs in Italy during the period from 1977 to 1999. All virus isolates were propagated in MDCK cells as described previously (8).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Antigenic and Genetic Evolution of Swine Influenza A (H3N2) Viruses in Europe

Jong

Smith

Lapedes

et al. 2007

J Virol

164

120

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In the early 1970s, a human influenza A/Port Chalmers/1/73 (H3N2)-like virus colonized the European swine population. Analyses of swine influenza A (H3N2) viruses isolated in The Netherlands and Belgium revealed that in the early 1990s, antigenic drift had occurred, away from A/Port Chalmers/1/73, the strain commonly used in influenza vaccines for pigs. Here we show that Italian swine influenza A (H3N2) viruses displayed antigenic and genetic changes similar to those observed in Northern European viruses in the same period. We used antigenic cartography methods for quantitative analyses of the antigenic evolution of European swine H3N2 viruses and observed a clustered virus evolution as seen for human viruses. Although the antigenic drift of swine and human H3N2 viruses has followed distinct evolutionary paths, potential cluster-differentiating amino acid substitutions in the influenza virus surface protein hemagglutinin (HA) were in part the same. The antigenic evolution of swine viruses occurred at a rate approximately six times slower than the rate in human viruses, even though the rates of genetic evolution of the HA at the nucleotide and amino acid level were similar for human and swine H3N2 viruses. Continuous monitoring of antigenic changes is recommended to give a first indication as to whether vaccine strains may need updating. Our data suggest that humoral immunity in the population plays a smaller role in the evolutionary selection processes of swine H3N2 viruses than in human H3N2 viruses.

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Antigenic drift in swine influenza H3 haemagglutinins with implications for vaccination policy

Cited by 53 publications

References 24 publications

Evolution of Swine H3N2 Influenza Viruses in the United States

Evolution of Swine H3N2 Influenza Viruses in the United States

Multiple lineages of antigenically and genetically diverse influenza A virus co-circulate in the United States swine population

Antigenic and Genetic Evolution of Swine Influenza A (H3N2) Viruses in Europe

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