Antigenicity of infant formulas: Role of immatureintestine on protein permeability

Eastham, Edmund J.; T, Lichauco; Grady, Michael I.; Walker, W. Allan

doi:10.1016/s0022-3476(78)80888-9

Cited by 137 publications

(33 citation statements)

References 15 publications

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“…We cite several reports based on SPT results or anecdotal data. For example Eastham et al stress that "Our results confirm recent clinical documentation that soy-based formulas are not at least as antigenic as the milk-based and should be used with caution" [7]. It is of note that these authors measured the production of hemagglutinins to CM and soy proteins, which mainly belong to the IgG class (and not IgE).…”

Section: Introductionsupporting

confidence: 78%

Over-Estimation of Soy Allergenicity: Laboratory Versus Challenge Tests: A Meta-Analysis

Cantani¹

2016

Ann Clin Lab Res

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Soybeans have been cultivated in Eastern countries for many centuries and soy protein formulas (SPFs) have been developed, which have been widely used for feeding infants with cow's milk (CM) allergy (CMA) since more 70 years. Several long-term studies have shown that the nutritional adequacy of SPFs allows normal growth and development when fed to normal and high risk infants. We emphasize that most studies base the diagnosis of soy allergy on clinical evaluation or anecdotal case histories reported by parents, but not on challenge tests, thus soy allergy has been highlighted in the last decades, due to an excessive reliance on skin prick tests (SPTs) and/or RAST. We deem that the incorrect definition of soy allergy and non appropriate diagnostic criteria have led to a large discrepancy on the prevalence of soy allergy in the medical literature which ranges from 3% up to 80%, but was very seldom compared to results of DBPCFC (double-blind placebo controlled challenge tests). In this paper we present factual evidence that objective scientific and laboratory data establish the true prevalence of soy allergy in children with CMA and in the general pediatric population. We demonstrate that the importance attributed to SPTs is completely not justifiable

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Section: Introductionsupporting

confidence: 78%

Over-Estimation of Soy Allergenicity: Laboratory Versus Challenge Tests: A Meta-Analysis

Cantani¹

2016

Ann Clin Lab Res

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“…A steady rise of antibodies to whey proteins during the first 3 months of life was reported in a group of infants fed a commercial formula. Passive antibody to whey proteins had been found in 23 of 25 cord sera in this study (5). Lower IgG antibodies to 8-lactalbumin, a-casein and /3-&in were found in the sera of infants after prolonged mixed feeding as compared to infants who had been weaned within less than 1 wk (8).…”

Section: Elisa-units (Eu)supporting

confidence: 45%

Oral Immunization to Milk Protein in Human Infants in the Presence of Passive Antibody

1983

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“…It frequently is assumed that normal infants have increased levels of serum antibodies to food protein because of enhanced intestinal absorption of antigenic dietary proteins (7). A further increase in absorption has been hypothesized in food-intolerant infants (27).…”

Section: Resultsmentioning

confidence: 99%

Food Protein-induced Enterocolitis: Altered Antibody Response to Ingested Antigen

et al. 1984

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Antigenicity of infant formulas: Role of immatureintestine on protein permeability

Cited by 137 publications

References 15 publications

Over-Estimation of Soy Allergenicity: Laboratory Versus Challenge Tests: A Meta-Analysis

Over-Estimation of Soy Allergenicity: Laboratory Versus Challenge Tests: A Meta-Analysis

Oral Immunization to Milk Protein in Human Infants in the Presence of Passive Antibody

Food Protein-induced Enterocolitis: Altered Antibody Response to Ingested Antigen

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