Antigens of Coccidioides posadasii as an Important Tool for the Immunodiagnosis of Coccidioidomycosis

Cordeiro, Rossana de Aguiar; Patoilo, Kharla Rabelo Nobre; Praciano, Silviane Bandeira; Medrano, Delia Jessica Astete; Marques, Francisca Jakelyne de Farias; Martins, Liline Maria Soares; Eulálio, Kelsen Dantas; Filho, Antônio de Deus; Cavalvanti, Maria do Amparo Salmito; Fechine, Maria Auxiliadora Bezerra; Brilhante, Raimunda Sâmia Nogueira; Camargo, Zoilo Pires de; Rocha, Marcos Fábio Gadelha; Sidrim, José Júlio Costa

doi:10.1007/s11046-012-9604-1

Cited by 9 publications

(7 citation statements)

References 48 publications

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“…Thus, this type of analysis has been used successfully to identify biomarkers for fungal diseases, including candidiasis [ 156 , 163 , 164 ], paracoccidioidomycosis [ 43 , 140 ], cryptococcosis [ 158 , 165 ], and is also aiming at the development of vaccines, diagnostic tests [ 154 , 166 ], clinical biomarkers [ 155 , 167 ] and comparative analyses [ 159 , 168 ]. Due to their effectiveness in the identification of antigenic molecules, these techniques have already been used in several studies of fungal antigens causing systemic mycoses, such as coccidioidomycosis [ 169 ], paracoccidioidomycosis [ 43 ], cryptococcosis [ 158 ], histoplasmosis [ 128 ] and sporotrichosis [ 159 ]. Recently, immunoproteomic studies aimed at identifying exoantigens of the Paracoccidioides complex have been carried out [ 43 ].…”

Section: Approaches Used To Search For New Diagnostic Candidatesmentioning

confidence: 99%

Challenges in Serologic Diagnostics of Neglected Human Systemic Mycoses: An Overview on Characterization of New Targets

et al. 2022

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Systemic mycoses have been viewed as neglected diseases and they are responsible for deaths and disabilities around the world. Rapid, low-cost, simple, highly-specific and sensitive diagnostic tests are critical components of patient care, disease control and active surveillance. However, the diagnosis of fungal infections represents a great challenge because of the decline in the expertise needed for identifying fungi, and a reduced number of instruments and assays specific to fungal identification. Unfortunately, time of diagnosis is one of the most important risk factors for mortality rates from many of the systemic mycoses. In addition, phenotypic and biochemical identification methods are often time-consuming, which has created an increasing demand for new methods of fungal identification. In this review, we discuss the current context of the diagnosis of the main systemic mycoses and propose alternative approaches for the identification of new targets for fungal pathogens, which can help in the development of new diagnostic tests.

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Section: Approaches Used To Search For New Diagnostic Candidatesmentioning

confidence: 99%

Challenges in Serologic Diagnostics of Neglected Human Systemic Mycoses: An Overview on Characterization of New Targets

et al. 2022

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“…Some studies have discussed difficulties in antibody detection during early time-points of the infection, as well as in immunosuppressed patients [136]. An alternative approach is the detection of fungal antigens in biofluids (typically sera) via antigen enzyme immunoassay [137]. For example, antibodies against fungal galactomannan could improve detection of coccidioidomycosis [138].…”

Section: Diagnosismentioning

confidence: 99%

The mysterious desert dwellers:Coccidioides immitis and Coccidioides posadasii, causative fungal agents of coccidioidomycosis

2019

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The genus Coccidioides consists of two species: C. immitis and C. posadasii . Prior to 2000, all disease was thought to be caused by a single species, C. immitis . The organism grows in arid to semiarid alkaline soils throughout western North America and into Central and South America. Regions in the United States, with highest prevalence of disease, include California, Arizona, and Texas. The Mexican states of Baja California, Coahuila, Sonora, and Neuvo Leon currently have the highest skin test positive results. Central America contains isolated endemic areas in Guatemala and Honduras. South America has isolated regions of high endemicity including areas of Colombia, Venezuela, Argentina, Paraguay, and Brazil. Although approximately 15,000 cases per year are reported in the United States, actual disease burden is estimated to be in the hundreds of thousands, as only California and Arizona have dedicated public health outreach, and report and track disease reliably. In this review, we survey genomics, epidemiology, ecology, and summarize aspects of disease, diagnosis, prevention, and treatment.

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“…(MiraVista Diagnostics, Indianapolis, Indiana), although there are reports of cross-reactions with histoplasmosis and blastomycosis. Antigenemia can be detected in more than 70% of immunocompromised subjects with severe or disseminated disease, a population in which serological tests are less reliable (de Aguiar- Cordeiro R et al, 2013& Durkin M et al, 2008.…”

Section: Diagnosismentioning

confidence: 99%

Interdisciplinary Science to Confront Coccidioidomycosis

Sarafoglou¹,

Laniado-Laborı́n²,

Sprigg³

et al. 2020

IJSSS

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The long journey of research to lower risks of Coccidioidomycosis (CM) began in the late 19th century in Argentina and continued north to Mexico, the US and other countries. During this trip, medical science led the way. Although interdisciplinary research is not alien to medical science, e.g. geographic epidemiology, interaction with other disciplines has been low priority. This paper argues that the efficacy of CM mitigation and treatment can be improved through multi- and inter-disciplinary information exchange, particularly with earth and environmental sciences. Greater interaction and open publication practice are essential. Section 1 describes CM-epidemiology, the clinical features, the diagnosis and finally, the treatment.Section 2 discusses epidemiological evidence for atmospheric influence on cases of CM.Section 3 highlights the most important contributions and controversies in the history of CM-research through scientometric or bibliometric evaluations of research that are based on Garfield’s work on the propagation of scientific thinking.

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Antigens of Coccidioides posadasii as an Important Tool for the Immunodiagnosis of Coccidioidomycosis

Cited by 9 publications

References 48 publications

Challenges in Serologic Diagnostics of Neglected Human Systemic Mycoses: An Overview on Characterization of New Targets

Challenges in Serologic Diagnostics of Neglected Human Systemic Mycoses: An Overview on Characterization of New Targets

The mysterious desert dwellers:Coccidioides immitis and Coccidioides posadasii, causative fungal agents of coccidioidomycosis

Interdisciplinary Science to Confront Coccidioidomycosis

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