Antihyperglycemic and antihyperlipidemic activities of 2-(4-[(2-hydroxybenzyl) amino]-phenyl amino-methyl)-phenol in STZ induced diabetic rats

Swapna, Sirasanagandla; Kasetti, Ramesh Babu; Shaik, Abdul Nabi; Natava, Rajesh; Surtineni, Venkata Prasad; Cirradur, Suresh Reddy; Chippada, Apparao

doi:10.1016/j.ejmech.2013.05.014

Cited by 10 publications

(6 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DM is one of the leading causes of death in the global scenario (Devi et al 2012). It is classified as defects in insulin secretion which is termed as type-1 (or) resistance to insulin action which is termed as type-2 (Sirasanagandla et al 2013). DM is associated with hyperglycemia which would cause damage to the blood vessels, eyes, nerves and kidneys.…”

Section: Introductionmentioning

confidence: 99%

Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats

et al. 2018

View full text Add to dashboard Cite

The aim of our study is to investigate the protective effect of against streptozotocin-induced diabetes inWistar albino rats. Rats were divided into five groups: group I was normal control, group II was diabetic control (50 mg/kg b.w. of streptozotocin, i.p.), group III was (400 mg/kg b.w., p.o.) treated diabetic rats; group IV was Glibenclamide (0. 6 mg/kg b.w., p.o.) treated diabetic rats and group V was treated with (400 mg/kg b.w., p.o.) alone. There was significant elevation in the levels of blood glucose, serum lipid profile and serum renal markers (total protein, urea, creatinine and uric acid) in the diabetic rats. Also, diabetic rats showed significantly ( < 0.05) reduced antioxidant status (reduced levels of superoxide dismutase, catalase, glutathione peroxidase, glutathione--transferase and reduced glutathione; increased levels of TBARS), impaired oral glucose tolerance and elevated HbA1C. was able to normalize the above mentioned parameters. Significant histopathological changes were found in the pancreas, liver and kidney sections of the diabetic control group while treatment with was able to minimize the extent of tissue damage. Current study shows that possesses significant antidiabetic and antihyperlipidemic effects in streptozotocin-induced diabetic rats by effectively reducing the rise in blood glucose levels and lipid profile.

show abstract

Section: Introductionmentioning

confidence: 99%

Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A significant relationship between diabetes and liver damage has been confirmed by many numerous previous research articles (Sirasanagandla et al, 2013;Xie et al, 2014;Muruganathan et al, 2017). In DM, hepatic glucose release dysregulation contributes significantly to these pathophysiological conditions.…”

Section: Introductionmentioning

confidence: 75%

The potency of , -diphenyl-1,4-phenylenediamine and adipose-derived stem cell co-administration in alleviating hepatorenal dysfunction complications associated with type 1 diabetes mellitus in rats

M. ABD EL-LATEEF,

H. QAHL,

FAYAD

et al. 2023

Biocell

View full text Add to dashboard Cite

Background: The increasing occurrence of diabetes mellitus (DM) noted worldwide has considerably elicited concern in the recent past. DM is associated with elevated vascular complications, morbidity, mortality, and poor quality of life. In this context, mesenchymal stem cells (MSCs) have shown significant therapeutic potentialities in managing and curing type 1 DM owing to their self-renewable, immunosuppressive, and differentiation capacities. We investigated the potential action of N, N′-diphenyl-1,4-phenylenediamine (DPPD), a well-known synthetic antioxidant to enhance the therapeutic ability of the adipose-derived stem cells (AD-MSCs) in alleviating kidney and liver complications in diabetic rats. Methods: Over the four weeks of experiments, albino male rats (n = 36) were split into six test groups: control, DPPD (250 mg/kg, i.p.), STZ-diabetic (D), D+DPPD, D+AD-MSCs (1 × 10 6 cell/rat, i.v.), and D+AD-MSCs +DPPD treated groups. Results: Significant declines in the renal and hepatic oxidative stress markers (MDA, ROS, and AGEs) were observed coupled with a significant elevation in many antioxidant marker levels (GSH, SOD, CAT, GPx, HO-1, and TAC) in the diabetic rats treated with either DPPD or AD-MSCs or their co-administered injection compared to the diabetic untreated rats. This was suggested to be the leading cause of amelioration of the kidney functions (as measured by urea, uric acid, and creatine levels) and liver functions (as evidenced by the levels of AST, ALT, ALP, bilirubin, total proteins, albumin, and globulins). Conclusion: DPPD and AD-MSCs co-administration showed superior results in terms of the enhancement of the relative hepato-renal function, indicating the beneficial role of DPPD supplementation in increasing the therapeutic potential of AD-MSCs.

show abstract

“…amino]-phenyl amino-methyl)-phenol at 30 mg/kg dose after diabetes mellitus induced by STZ. Thirtyday care of STZ rats with HBPMP 30 mg/kg resulted in a substantial reduction in their fasting blood sugar (FBS) amounts (Sirasanagandla et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Anti-diabetic effect of Biological activities of 2-(4- [(2-hydroxy benzyl) amino]-phenyl amino-methyl)-phenol derivatives on Alloxan induced rats

Chandra¹,

Kudagi²,

Buchineni³

et al. 2020

ijrps

View full text Add to dashboard Cite

The word diabetes describes a category of metabolic disorders characterised and defined by hyperglycemia in the absence of therapy. Type 1 & 2 diabetes mellitus are two main types. It is now widely accepted that failure or loss of pancreatic β (beta) cells is the underlying common feature of all types of diabetes. In this study, male Wistar albino rats of approximate weighing 180-250 g were used. Compound 2-(4-[(2-hydroxy benzyl) amino]-phenyl amino-methyl)-phenol derivatives were used to assess the anti-diabetic activity. Derivatives such as hydroxyl amino, acetyl keto, and hydro benzophenone groups are derivatives and are further studied for the screening of anti-diabetic activity. Diabetes was produced by intraperitoneal administration of Alloxan in male Wistar albino rats. Rats were divided into 12 groups of six in each group. The outcomes of the study reveal compound C - 60 mg/kg shows significance in decreasing the blood sugar level when compared to control. A significant effect on blood sugar levels was shown by glibenclamide 20 mg/kg. The study concludes that Biological activities of 2-(4- [(2-hydroxy benzyl) amino]-phenyl amino-methyl)-phenol derivatives of compound C - 60 mg/kg has high blood sugar-lowering activity.

show abstract

Antihyperglycemic and antihyperlipidemic activities of 2-(4-[(2-hydroxybenzyl) amino]-phenyl amino-methyl)-phenol in STZ induced diabetic rats

Cited by 10 publications

References 38 publications

Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats

Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats

The potency of , -diphenyl-1,4-phenylenediamine and adipose-derived stem cell co-administration in alleviating hepatorenal dysfunction complications associated with type 1 diabetes mellitus in rats

Anti-diabetic effect of Biological activities of 2-(4- [(2-hydroxy benzyl) amino]-phenyl amino-methyl)-phenol derivatives on Alloxan induced rats

Contact Info

Product

Resources

About