Antihyperglycemic Effect of Umbelliferone in Streptozotocin-Diabetic Rats

Ramesh, B.; Pugalendi, Kodukkur Viswanathan

doi:10.1089/jmf.2006.9.562

Cited by 162 publications

(105 citation statements)

References 22 publications

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“…This point is in agreement with the findings of other reports (Greene and Lattimer, 1983;Kim et al, 2006;Mazloomi et al, 2010;Musabayane et al, 1995;Ramesh and Pugalendi, 2006;Sajedianfard et al, 2013). In the diabetic control group, from the first day until the end of the study weight loss was 24.5%.…”

Section: Discussionsupporting

confidence: 93%

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

Sajedianfard¹,

Nazifi²,

Shamsaei³

2014

American Journal of Animal and Veterinary Sciences

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In this research, the effect of oral administration of different doses of hydroalcoholic extract of silymarin on the status of trace elements with antioxidant properties (Se, Cu, Zn, Mn and Fe) was studied. Fifty male rats were randomly used in five groups including healthy control group (treated by saline), diabetic control group (treated by saline) and three diabetic groups that were daily treated by different oral dose of silymarin (100, 175 and 250 mg kg −1 ). Diabetes was induced by intraperitoneal injection of streptozotocin (50 mg kg −1 ) in rats. Rats were orally treated for 14 days by gavage. Weight was measured before STZ injection, 7 and 14 days after treatment. The blood glucose was measured before injection of STZ, 3 days after injection and 7 and 14 days after diabetes was induced (under treatment by silymarin). At the end of the study, blood samples were taken by heart puncture. Results showed that the average weight increased during the 14 days of treatment with silymarin and the blood glucose was decreased. Hydroalcoholic extract of silymarin increased trace elements levels in treated groups by dose-dependent manner. The present study showed that in diabetic rats, high therapeutic doses of silymarin had a major effect on serum antioxidant factors. Results also showed that hydroalcoholic extract of silymarin increased the body weight and decreased serum glucose concentration at the end of the treatment period. Silymarin in a dose dependent manner could improve trace element levels in diabetic rats. Therefore, it may cause reduction of oxidative stress in the diabetic rats.

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Section: Discussionsupporting

confidence: 93%

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

Sajedianfard¹,

Nazifi²,

Shamsaei³

2014

American Journal of Animal and Veterinary Sciences

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“…Interestingly, esculetin and quercetin showed almost the same moderate inhibitory activity toward sucrase, with IC 50 values of 72 and 71 µM, respectively ( Table 1), but the suppressive effects on the blood glucose levels were obviously greater in the esculetin-treated group. Ramesh et al (27) have reported that umbelliferone significantly elevated the plasma insulin level as compared with nontreated diabetic rat, and it caused a reduction in the blood glucose level. In the present study, we were not able to find any significant inhibitory activity of umbelliferone (1) against R-amylase, maltase, and sucrase ( Table 1).…”

Section: Results and Disussionmentioning

confidence: 99%

Protective Effects of Dietary Chamomile Tea on Diabetic Complications

Kato

Minoshima

Yamamoto

et al. 2008

J. Agric. Food Chem.

162

101

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Matricaria chamomilla L., known as "chamomile", has been used as an herbal tea or supplementary food all over the world. We investigated the effects of chamomile hot water extract and its major components on the prevention of hyperglycemia and the protection or improvement of diabetic complications in diabetes mellitus. Hot water extract, esculetin (3) and quercetin (7) have been found to show moderate inhibition of sucrase with IC 50 values of 0.9 mg/mL and 72 and 71 µM, respectively. In a sucrose-loading test, the administration of esculetin (50 mg/kg body weight) fully suppressed hyperglycemia after 15 and 30 min, but the extract (500 mg/kg body weight) and quercetin (50 mg/ kg body weight) were less effective. On the other hand, a long-term feed test (21 days) using a streptozotocin-induced rat diabetes model revealed that the same doses of extract and quercetin showed significant suppression of blood glucose levels. It was also found that these samples increased the liver glycogen levels. Moreover, chamomile extract showed potent inhibition against aldose reductase (ALR2), with an IC 50 value of 16.9 µg/mL, and its components, umbelliferone (1), esculetin (3), luteolin (6), and quercetin (7), could significantly inhibit the accumulation of sorbitol in human erythrocytes. These results clearly suggested that daily consumption of chamomile tea with meals could contribute to the prevention of the progress of hyperglycemia and diabetic complications.

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“…A wide range of pharmacological activities of HOC is demonstrated in animal studies. The compound lowers serum GLU (glucose) level in rats with streptozotocin diabetes, exhibit antioxidant, antinociceptive and anti-inflammatory effects, is used as derivative in the synthesis of drugs [2][3][4][5][6][7]. The recent study showed that HOC is α-amylase and α-glucosidase inhibitor in vitro [8], causes neuroprotective effects [9,10], attenuate alcohol-induced fatty liver in rats [11].…”

mentioning

confidence: 99%

Single and Repeat Dose Toxicity Study of 7-Hydroxycoumarin, Ethanol, and Their Mixture in Rats

Zinovieva¹,

Zhminko²

2017

JPP

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Acute and repeat-dose toxic effects of HOC (7-hydroxycoumarin), ethanol and their mixture were studied in rats. Single oral administration of HOC (5,000 mg/kg) caused transitional glycosuria associated with lowered serum glucose levels, decreased urea clearance. HOC given orally during 28 days (200 mg/kg) decreased serum glucose, and increased serum triglyceride concentrations. No enhancement of acute toxic effect of HOC (5,000 mg/kg) and ethanol (6,000 mg/kg) mixture was found in the acute toxicity study phase. Effect of HOC (200 mg/kg) and ethanol (750 mg/kg) during 28 days of exposure was less pronounced in comparison with HOC effect only, as far as neither decrease of glucose, nor increase of triglyceride serum concentrations were found.

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Antihyperglycemic Effect of Umbelliferone in Streptozotocin-Diabetic Rats

Cited by 162 publications

References 22 publications

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

Protective Effects of Dietary Chamomile Tea on Diabetic Complications

Single and Repeat Dose Toxicity Study of 7-Hydroxycoumarin, Ethanol, and Their Mixture in Rats

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