Antihyperlipidemic Activity of Gymenma sylvestre R. Br. Leaf Extract 
 on Rats Fed with High Cholesterol Diet

Rachh, Punit R.; Rachh, M. R.; Ghadiya, N. R.; Modi, Dikshit C.; Modi, Ketan; Patel, N; Rupareliya, M. T.

doi:10.3923/ijp.2010.138.141

Cited by 40 publications

(29 citation statements)

References 11 publications

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“…Similar observations were reported in several studies (He et al, 2008;Amin and Nagy, 2009;Koya-Miyata et al, 2009;Lee et al, 2009;Bhalodia et al, 2010;Rachh et al, 2010). Administration of Coenzyme Q10 for last month inhibited the percentage change of body weight in rats treated with high cholesterol diet and con oil.…”

Section: Discussionsupporting

confidence: 77%

“…Diet-induced hypercholesterolemia has long been useful for the assessment of agents interfering with the absorption, degradation and excretion of cholesterol, rather than interfering with cholesterol biosynthesis. Indeed, many animal species have been used in experiments to evaluate the hypercholesterolemic effect of highcholesterol and high-fat diet (Beere et al, 1992;Ramirez-Tortosa et al, 1999;Hsu and Yen, 2007;Zulkhairi et al, 2008;Kanashiro et al, 2009;Kim et al, 2009;Shimoda et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

Al-Attar¹

2010

American Journal of Pharmacology and Toxicology

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Problem statement: Hyperlipidemia is well known to play a main role in the development of atherosclerosis. It is characterized by abnormally elevated cholesterol, triglyceride, low density lipoprotein cholesterol and very low density lipoprotein cholesterol levels in the blood. It has been recognized for many years that hypercholesterolemia is a major risk factor for cardiovascular diseases such as atherosclerosis, myocardial infraction, heart attacks and cerebrovascular diseases. In recent years, Coenzyme Q10 has gained considerable attention as a dietary supplement capable of influencing cellular bioenergetics and as a supplementary treatment for some chronic diseases. Approach: The present study was undertaken to evaluate whether Coenzyme Q10 supplementation would alter high cholesterol dietinduced hypercholesterolemic model in female rats. Sixty female albino rats of the Wistar strain weighing between 34.3 and 42.1 g were used. The experimental animals were divided into six groups. Rats of group 1 served as controls, fed with standard diet and had free access to water for three months. Rats of group 2 were daily supplemented with 1 mL of corn oil containing 10 mg of cholesterol/rat for two months. Animals of group 3 were daily supplemented with 1 mL of corn oil containing 10 mg of cholesterol/rat for two months and daily supplemented with 1 mg Coenzyme Q10/rat at third month. Rats of group 4 were daily supplemented with 1 mL of corn oil /rat for two months. The experimental rats of group 5 were daily supplemented with 1 mL of corn oil /rat for two months and daily supplemented with 1 mg Coenzyme Q10/rat at third month. Rats of group 6 were supplemented with 1 mg Coenzyme Q10/rat at third month. The body weight percentage changes were determined after second and third months in all experimental groups. Results: After 2 months, the maximum changes of body weight were noted in groups treated with high cholesterol diet and corn oil. After three months, the maximum percentage changes were observed in groups two and four and the minimum changes were noted in sixth group supplemented with only Coenzyme Q10 at last period. Serum triglycerides, cholesterol, High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C), Very Low Density Lipoprotein Cholesterol (VLDL-C), Atehrogenic Index (AI) and HDL Cholesterol (HDL-C) ratio were assessed at the end of experimental period. Significant increases in the levels of triglycerides, cholesterol, LDL-C VLDL-C were noted in rats supplemented with high cholesterol diet, while the level of HDL-C was significantly reduced. Similar observations were noted in rats treated with high cholesterol diet plus Coenzyme Q10. Statistically, the treatment of Coenzyme Q10 in rats subjected to high cholesterol diet showed a decrease in the change levels of these parameters. Also, the Atehrogenic Index (AI) value was significantly elevated in rats supplemented with high cholesterol diet compared with control value. Administration of Coenzyme Q10 for a peri...

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

Al-Attar¹

2010

American Journal of Pharmacology and Toxicology

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“…This concluded that extract of Gymnema sylvestre R. Br. Leaf contained phenolic compounds that resulted in antihyperlipidemic activity [16].…”

Section: Literature Reviewmentioning

confidence: 99%

A Review of antihyperlipidemic effect of synthetic phenolic compounds

Nawaz¹,

Shareef²,

Shahid³

et al. 2017

Matrix sci. medica

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It is seen that most of the deaths are occurring due to diseases of cardiovascular system. There is a significant impact of lifestyle changes on the quality of health. Utilization of food highly rich with saturated fat and having low fiber content is one of the factors of disarray in energy balance. It is now evinced that hyperlipidemia is depicted as a major risk factor for the premature development of atherosclerosis and its cardiovascular complications. The prevalence of obesity has doubled in the past 25 years; today, two-thirds of adults are overweight in the United State [1].

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“…Swiss albino mice were used in this study because they are the preferable animal for evaluation of learning and memory. Hyperlipidemia was induced by replacing the normal diet with high fat diet (HFD) consisting of cholesterol, cholic acid and coconut oil mixed in powdered normal pellet diet [8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…It was prepared by mixing Cholesterol 2%, Cholic acid 1%, Coconut oil 5%, Standard pellet diet powder 92% [8][9][10][11][12]. This mixture was made into small rounds and was baked.…”

Section: High Fat Diet (Hfd)mentioning

confidence: 99%

Effect of Atorvastatin on Memory in Albino Mice

Kadali

2014

JCDR

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Antihyperlipidemic Activity of Gymenma sylvestre R. Br. Leaf Extract on Rats Fed with High Cholesterol Diet

Cited by 40 publications

References 11 publications

Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

A Review of antihyperlipidemic effect of synthetic phenolic compounds

Effect of Atorvastatin on Memory in Albino Mice

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