In this study, a novel magnetic mesoporous MCM-41 silica supported ionic liquid/palladium complex (Fe 3 O 4 @MCM@IL/Pd) with core-structure was prepared and characterized and its catalytic performance was developed under green conditions. The Fe 3 O 4 @MCM@IL/Pd was prepared via a post grafting method and was characterized using Fourier transform infrared spectroscopy, thermal gravimetric analysis, wide-and low-angle powder X-ray diffraction, scanning electron microscopy, transmission electron microscopy, vibration sample magnetometer and energy-dispersive X-ray analyses. This was applied as an efficient and recoverable nanocatalyst for the one-pot synthesis of pyrano [2,3-d]pyrimidine derivatives under ultrasonic conditions. The catalyst was magnetically recovered and reused for 12 consecutive cycles without significant loss of its activity and selectivity.