Antihypertensive effect of corn peptides, produced by a continuous production in enzymatic membrane reactor, in spontaneously hypertensive rats

Isolation and identification of a novel peptide from zein with antioxidant and antihypertensive activities

“…Many kinds of peptides derived from food proteins are known to exhibit ACE inhibitory activity and are considered to be milder and safer as compared to synthetic drugs. 22 In other studies on plant proteins and peptides such as grass carp protein and peanut protein hydrolysates, it was also found that the ACE inhibition capacity was increased with the increase of hydrolysis and the M w < 3 kDa fraction showed a higher ACE inhibitory activity than the fractions with a M w of 3-10 kDa or above 10 kDa. 21 The ACE inhibitory activity of different CP fractions is presented in Fig.…”

Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides

“…For example, enzymatic food protein hydrolysates and peptides with antihypertensive activities have been widely demonstrated García-Tejedor et al, 2014;He, Alashi, Malomo, et al, 2013;He, Malomo, Alashi, et al, 2013;He, Malomo, Girgih, Ju, & Aluko, 2013;Huang, Sun, He, Dong, & Li, 2011;Li et al, 2011;Majumder et al, 2013;Yamada et al, 2013). Some of the reports have also shown that the blood pressure-lowering effect of the food protein hydrolysates and peptides is related to direct in vivo reduction in plasma ACE and renin activities (García-Tejedor et al, 2014;Girgih, Alashi, He, Malomo, & Aluko, 2014;Huang et al, 2011). A recent report has shown the uptake of a casein-derived peptide (HLPLP) from the gastrointestinal tract into rat blood, which confirms that some of these food protein-derived peptides could be bioavailable .…”

Changes in arterial blood pressure after single oral administration of cuttlefish (Sepia officinalis) muscle derived peptides in spontaneously hypertensive rats

“…Nevertheless, it is important to test the effect of the ACEinhibitory compounds in vivo to establish their possible usefulness against hypertension. Most of studies performed to determine the antihypertensive effects of ACE-inhibitory peptides have used SHR rats (Huang et al, 2011;Lee et al, 2010;Wang et al, 2008). In vivo effects are usually tested in this strain, because SHR constitute an accepted model for human essential hypertension (FitzGerald, Murray, & Walsh, 2004).…”

“…Researchers have obtained ACE inhibitory peptides from various natural resources (Chen et al, 2009;Fitzgerald, Gallagher, Tasdemir, & Hayes, 2011;Herná ndez-Ledesma, del Mar Contreras, & Recio, 2011) and some of these sequences have also been verified in vivo, proving their antihypertensive effect. Thus, it has been demonstrated that certain food peptides can decrease arterial blood pressure in hypertensive animals after single oral doses (Contreras, Carron, Montero, Ramos, & Recio, 2009;Huang, Sun, He, Dong, & Li, 2011;Lee, Qian, & Kim, 2010;Quiros et al, 2007) and after long-term administration (Miguel, Lopez-Fandino, Ramos, & Aleixandre, 2006a;Miguel et al, 2005;Sipola et al, 2001;Yang, Yang, Chen, Tzeng, & Han, 2004). In addition, some of the food-derived peptides with ACE-inhibitory activity effectively reduced systolic blood pressure (SBP) and diastolic blood pressure (DBP) in hypertensive patients (Boelsma & Kloek, 2009;Seppo, Jauhiainen, Poussa, & Korpela, 2003;Usinger, Ibsen, & Jensen, 2009;Xu, Qin, Wang, Li, & Chang, 2008).…”