Antiinflammatory activity of isoflavonoids fromPueraria radix and biochanin A derivatives

Lee, Song Jin; Baek, Ho Jin; Lee, Changhee; Kim, Hyun Pyo

doi:10.1007/bf02978244

Cited by 26 publications

(15 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the HMBC correlations δ H 7.82 (H-1)/δ C 41.3 (C-1'), 154.5 (C-4a), and 160.9 (C-11a), and δ H 1.59 (H-4' and 5')/δ C 133.6 (C-2) clearly indicated that the α,α-dimethylallyl group was located at C-2. These spectroscopic data of compound 1 were almost the same as those of puerarol (2) (Lee et al, 1994), which was also isolated and identified in this study, except for the absence of geranyl group signals and the presence of signals corresponding one α,α-dimethylallyl unit. Accordingly, the structure of the new compound 1 was elucidated as 2-(α,α-dimethylallyl)coumestrol.…”

Section: Resultssupporting

confidence: 53%

“…Additionally, 11 compounds of previously known structures were identified as puerarol (2) (Lee et al, 1994), daidzein (3) (Baek et al, 2009), formonetin (4) (Kinjo et al, 1987), daidzin (5) (Baek et al, 2009), ononin (6) (Baek et al, 2009), 4',8-dimethoxyisoflavone 7-O-β-D-glucose (7) (Kaneko et al, 1988), genistein (8) (Kinjo et al, 1987), biochanin A (9) (Baek et al, 2009), sissotrin (10) (Lewis et al, 1998), puerol B (11) (Nohara et al, 1993), and puerol B 2-O-β-D-glucose (12) (Baek et al, 2009), respectively, by analysis of their NMR data and comparison of their physical and spectral data with those of literature values.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity

Choi

Hong

Shin³

et al. 2010

Arch. Pharm. Res.

View full text Add to dashboard Cite

Bioassay-guided fractionation of the EtOAc-soluble extract of Pueraria lobata based on the inhibition of Aβ-induced toxicity in PC12 cells resulted in the isolation of four known active compounds, genistein (8), biochanin A (9), sissotrin (10), and puerol B (11). Of these, genistein (8) and biochanin A (9) exhibited potent neuroprotective effects with ED(50) values of 33.7 and 27.8 μM, respectively. In addition, a new coumestan, 2-(α,α-dimethylallyl)coumestrol (1) was isolated and characterized, but proved to be inactive, as were additional seven known compounds. The structure of new compound 1 was determined using spectroscopic techniques.

show abstract

Section: Resultssupporting

confidence: 53%

Section: Resultsmentioning

confidence: 99%

Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity

Choi

Hong

Shin³

et al. 2010

Arch. Pharm. Res.

View full text Add to dashboard Cite

show abstract

“…Podocarpaceae is one of the non-leguminous families that produce isoflavonoids (Lapčík, 2007). A number of natural and synthetic isoflavonoids are known to possess potent antioxidant and antiinflammatory activities (Lee et al, 1994;Rahman et al, 2003;Pan et al, 2005).…”

Section: Discussionmentioning

confidence: 97%

Anti-inflammatory, antioxidant, anti-tyrosinase and phenolic contents of four Podocarpus species used in traditional medicine in South Africa

Abdillahi

Finnie

Staden

2011

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…It gave the main biological compound, which the signals were clearly visible in the 1 H-NMR spectrum. Perhaps, the obvious were chemical shifts were between weak 3.0 ppm (Lee et al, 1994).…”

Section: Analysis Of Total Phenolics and Flavonoid Contents Of The Gamentioning

confidence: 99%

Free radical scavenging activity and kinetic behavior of the Galgeuntang water extract

Shin¹,

Kim²,

Baek

2008

Oriental Pharmacy and Experimental Medicine

View full text Add to dashboard Cite

SUMMARYGalgeuntang water extract exhibited a strong free radical scavenging activity and reducing power determination. However, a gradual increase in the free radical scavenging activity and reducing power determination was obtained with increasing concentrations. The highest radical scavenging activity was shown by the water extract from Galgeuntang (116.93 μg/mL) and the water extract from Cinnamonum cassia Presl. (95.01 μg/mL). These results of phenolic and flavonoid contents of the extracts indicated that the strong radical scavenging activity of the Cinnamonum cassia Presl. extract might be in part due to the phenolic compounds. The correlation coefficient between TPC and DPPH (r 2 = 0.9312), TFC and DPPH (r 2 = 0.9677), showed positive correlation among total phenolic/flavonoid contents and antioxidant activity. These results suggest that Galgeuntang has a potential antioxidant activity.

show abstract

Antiinflammatory activity of isoflavonoids fromPueraria radix and biochanin A derivatives

Cited by 26 publications

References 6 publications

Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity

Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity

Anti-inflammatory, antioxidant, anti-tyrosinase and phenolic contents of four Podocarpus species used in traditional medicine in South Africa

Free radical scavenging activity and kinetic behavior of the Galgeuntang water extract

Contact Info

Product

Resources

About