Antiinflammatory Activity of Pagoda Flower (Clerodendrum Paniculatum L.) Ethanol Extract Using Paw Edema Method

Abstract

Objectives: The purpose of this study was to determine antiinflammatory activity of pagoda flower (Clerodendrum paniculatum L.) ethanolic extract
 Design: This study uses an experimental laboratory design. This research uses paw edema method by inducing carrageenin in the legs of male white rats as an induction of inflammation.
 Interventions: The sample used was pagoda flower ethanol extract in various dosages of 25, 50 and 100 mg / kg. As a comparison, acetosal dose 33 mg / kg was used. Na CMC suspension was used as a negative control.
 Main outcome measure: The results in this study are the difference in the volume of edema volume from rat feet per unit time. The measurement of the rat's leg volume was measured at 30, 60, 120, 180, 240 and 300 minutes.
 Conclusion: Pagoda flower ethanol extract does not have good anti-inflammatory activity. there were no significant differences between groups except at dose 100 and positive control at minute 300 of negative control.
 

Anti-inflammatory Activity of Ethanol Extract of Lotus (Nelumbo nucifera G.) Seed Against White Male Rats Using Paw Edema Method

“…Extract samples were made in suspension dosage form. 1% Na CMC suspension was used as a negative control as well as the basis for the suspension of the entire sample 14 . Lotus seed extract is formulated in the form of a suspension which can then be given to the test animals at doses of 200, 300 and 400 mg/kg bw.…”

“…During this process, rats are maintained so that their food and drinking needs can be fulfilled. The rats were fasted for 8 hours before treatment but water was still given 14 .…”

“…The antiinflammatory activity given by a drug/test preparation is expressed as the percentage of inflammation. The data obtained from the five groups were analyzed by one way analysis of variance (ANOVA) 15 .…”

Penapisan Senyawa Kimia Tumbuhan dan Daya Hambat Pertumbuhan Bakteri dari Fraksi n-Heksan Daun Pagoda (Clerodendrum paniculatum L.) terhadap Bakteri Staphylococcus aureus dan Staphylococcus epidermidis

“…Selain sebagai antibakteri, tanaman pagoda dan sejenisnya diketahui memiliki aktivitas farmakologi sebagai antivirus, antioksidan, antihipertensi, antiinflamasi, antiplatelet dan berpotensi antikanker (Hafiz et al, p-ISSN 1693-3591 (Pharmaceutical Journal of Indonesia) e- ISSN 2579-910X Vol.18 No. 02 Desember 2021: 334-344 2019b, 2019a, 2016Hafiz and Ginting, 2019;Pertiwi et al, 2020b).…”

Determination of Antiradical Activity, Total Phenolic and Flavonoid Contents of Kamena-mena Kamena-mena (Clerodendrum paniculatum. L) Leaves

“…7 Several studies have reported that C. paniculatum leaves have pharmacological activity, such as anti-bacterial activity, 8 antioxidant activity, 9 anti-inflammatory activity in vitro and in vivo, 10 and antioxidant activity in vitro and antiinflammatory in vivo. 11 This study aims to evaluate the antiradical activity of extract and fractions of Kamena-mena (Clerodendrum paniculatum Linn) leaf using the DPPH (2, 2-diphenyl-1-picryhidrazyl) and ABTS (2, 2'azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) method and determination of phenolic and flavonoid contents.…”