Antiinflammatory Activity of the Aqueous Extract of Gynura Cusimba Moore in Albino Rats

Abstract

Traditional medicines are most commonly used to meet the health care needs especially in developing countries. Gynura cusimba (D.Don) Moore has been traditionally used as a medicinal plant for healing wounds, headache and as anti-ulcer for centuries. The present study was taken to evaluate the antiinflammatory properties in suitable animal experimental model. Antiinflammatory activity of the aqueous extract of the plant was observed using carrageenan induced rat paw oedema. The foot/paw volume was measured by the modified plethysmographic method. The test drug at doses of 500,1000 and 2000mg/kg produced 16.67%, 33.34% and 44.44% inhibition of paw oedemas compared to 72.29% inhibition produced by the standard drug, Aspirin. It thus showed a significant antiinflammatory activity.

Anti-Ulcer Effect of Aqueous Extract of Gynura cusimbua (D.Don) S.Moore on Swimming Stress Ulcer Model in Albino Rats

“…[8] This anti-ulcer/ gastro protective activity can be attributed to the presence of several phytochemicals in Gynura cusimbua, chiefly flavonoids which are a consistent presence in the plants of genus Gynura, family asteraecea as determined by Ibrahim MH and Kong YC et al, [19] Akhi TM and Adib M et al [20] and Hassali HA et al [21] Additionally the antiinflammatory activity of the test drug, as established in a previous study could further help in reducing the occurrence of gastric ulcer and reducing the ulcer index in the experimental animals. [6] The test for toxicity showed no acute moribund or mortality, consistent with the findings of Mahmood AA et al [8]…”

“…[5] Previously the test plant, Gynura cusimbua, has been studied for the anti-inflammatory effect using the carrageenan induced paw oedema model with favourable results. [6] Additional the plant has been studied for the antiulcer effect using the aspirin plus pylorus ligation model in albino rats which revealed that it has significant antiulcer properties. [7] Gynura procumbens a close relative of the test plant Gynura cusimbua has been studied by Mahmood AA et al, [8] for the anti-ulcer effect using ethanol induced ulcer in the albino rats as an experimental model.…”

Evaluation of anti-inflammatory effects of the aqueous extract of Stephania rotunda in experimental animals

“…The method of Marak et al was followed to study the inflammatory effect with some modification. 16 The percentage of antiinflammatory activity was then calculated by the formula of Tewari et al and Diniz et al 17,18 𝑃𝑒𝑟𝑐𝑒𝑛𝑡𝑎𝑔𝑒 𝑜𝑓 𝑖𝑛ℎ𝑖𝑏𝑖𝑡𝑖𝑜𝑛 = 𝑉𝑐 − 𝑉𝑡/𝑉𝑐 × 100…”

“…On the seventh day, the pouch was opened under ether anaesthesia and the exudate was sucked out and the amount measured. The percentage inhibition was then calculated for the different groups of drugs as compared to the control group with reference to Tewari et al and Diniz et al [17][18][19] The data thus obtained was analysed and the mean comparison was done using ANOVA via Dunnett's T test and p value less than 0.05 was taken to be statistically significant.…”