Antikörpertiterverlauf gegen Epstein-Barr-Virus-spezifische Antigene bei infektiöser Mononukleose mit Tonsillektomie in der akuten Krankheitsphase

Sauerbrei, Andreas; Sprössig, M; Wutzler, Peter; Färber, I; Schweizer, H; Swoboda, R; Wilke, Joachim

doi:10.1055/s-2007-1008407

Cited by 8 publications

(5 citation statements)

References 3 publications

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“…TE in 23 Patients with a proven infectious mononucleosis resulted in a significant shortening of the reconvalescence. But also an increased susceptibility for a recurrence [489]. Tonsillar asymmetry was acknowledged as proper indication for TE, potentially as bilateral procedure.…”

Section: Resultsmentioning

confidence: 99%

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Indications for tonsillectomy stratified by the level of evidence

Windfuhr

2016

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 15:Doc09

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Section: Resultsmentioning

confidence: 99%

“…If complicated by airway obstruction or tonsillar hemorrhage TE is an option to alleviate the symptoms. Although TE can reduce the duration of the disease but may also compromise the immune system [489] (grade A), [496] (grade C).…”

Section: Resultsmentioning

confidence: 99%

Indications for tonsillectomy stratified by the level of evidence

Windfuhr

2016

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 15:Doc09

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“…Bei anamnestisch rezidivierender akuter Tonsillitis könne die OP-Indikation großzügiger gestellt werden. Bei der infektiösen Mononukleose verwiesen die Autoren auf die Publikation von Sauerbrei et al [514], in der sich bei der Hälfte von 23 Patienten die Krankheitsdauer durch die TE halbieren ließ. Allerdings konnten die tonsillektomierten Patienten nur einen geringeren Immunschutz aufbauen, waren also eher rezidivgefährdet.…”

Section: Wolfensberger Und Mund [37]unclassified

Evidenz basierte Indikationen der Tonsillektomie

2016

Laryngo-Rhino-Otol

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1) The literature suggests, that TE is not indicated to treat otitis media with effusion. 2) It has been shown, that the PFAPA-syndrome is self-limiting and responds well to steroid administration, at least in a considerable amount of children. The indication for TE therefore appears to be imbalanced but further research is required to clarify the value of surgery. 3) Abscesstonsillectomy as a routine is not justified and indicated only for cases not responding to other measures of treatment, evident complications, or with a significant history of tonsillitis. In particular, interval-tonsillectomy is not justified as a routine. 4) TE, with or without adenoidectomy, is efficacious to resolve sleep-related breathing disorders resulting from (adeno)tonsillar hypertrophy in children. However, the benefit is reduced by co-morbidities, such as obesity, and further research required to identify prognostic factors for this subgroup of patients. Further research is indicated to clarify selection criteria not only for this subpopulation that may benefit from less invasive procedures such as tonsillotomy in the long-term. 5) Further trials are also indicated to evaluate the efficacy of TE on the clinical course in children with psoriasis guttata as well as on psoriasis vulgaris in adults, not responding to first-line therapy. 6) Conflicting results were reported concerning the role of TE in the concert to treat Ig-A nephropathy, mandating further clinical research. 7) Most importantly, randomized-controlled clinical trials with an adequate long-term follow-up are desirable to clarify the benefit of TE in patients with recurrent episodes of tonsillitis, with or without pharyngitis. Factors like age, spontaneous healing rate and postoperative quality of life have to be included when comparing TE with antibiotic therapy.

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“…EBV-specific antibodies Table III gives the appearance and persistence of the antibodies with their respective reactivities. There is no cure for infectious mononucleosis other than time, although the clinical symptoms and the antibody titers reportedly reach normal values much faster, especially in severe cases, when the tonsils are removed [12]. The tonsils may be the primary site of immunologic defense and the reservoir or "recruitment center" of B-lymphocytes able to proliferate.…”

Section: Infectious Mononucleosis As the Primary Disease Caused By Ebvmentioning

confidence: 99%

Benign and Malignant Disease Caused by EBV.

Wolf¹,

Seibl²

1984

J Invest Dermatol

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Epstein-Barr virus (EBV) causes infectious mononucleosis as a primary disease. The virus infects more than 90% of the average population and persists lifelong in peripheral B-lymphocytes. The virus is produced in the parotid gland and spread via the oral route. Serology suggests that the Epstein-Barr virus might be involved in the causation of two neoplastic diseases of humans: African Burkitt's lymphoma and nasopharyngeal carcinoma. Whereas the development of the lymphoma has an even better linkage with chromosomal rearrangements, nasopharyngeal carcinoma shows a unique association with Epstein-Barr virus. Environmental factors, including traditional Chinese medicine, may be responsible for the enhanced risk of nasopharyngeal carcinoma in certain, predominantly Chinese, populations of southern Asia. Possible mechanisms leading to the establishment of the neoplastic manifestations will be discussed.

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Antikörpertiterverlauf gegen Epstein-Barr-Virus-spezifische Antigene bei infektiöser Mononukleose mit Tonsillektomie in der akuten Krankheitsphase

Cited by 8 publications

References 3 publications

Indications for tonsillectomy stratified by the level of evidence

Indications for tonsillectomy stratified by the level of evidence

Evidenz basierte Indikationen der Tonsillektomie

Benign and Malignant Disease Caused by EBV.

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