2014
DOI: 10.1021/np5000473
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Antileishmanial Metabolites from Geosmithia langdonii

Abstract: Antileishmanial bioassay guided fractionation of Geosmithia langdonii has resulted in the isolation and identification of two new compounds (1 and 2) together with 10 known compounds (3–12). The structures of the isolated metabolites were elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as mass spectrometry. The absolute configuration at C4, C5, and C6 of 2 was determined as R using a modified Mosher esterification method and NOESY correlations. The extracts and the isolated metabolit… Show more

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Cited by 27 publications
(23 citation statements)
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“…All the spectroscopic data of the known structures 2,2′methylenebis(3-methylphenol) (8), 6-methylsaligenin (9), (3-hydroxy-1,2-phenylene)dimethanol (10), and 3-(hydroxymethyl)- 2-(methoxymethyl)phenol (11) were consistent with those reported in the literature [9][10][11][12]. Although the mouse lymphocytic leukemia cell line (P388) was used to screen the extract, the cytotoxic potential of compounds 1-7 were evaluated against three selected human-originated cell lines (HeLa, HL-60, and HCT-116 cell lines) (l " [13], microorganisms [14,15], and terrestrial plants [16][17][18][19][20][21]. Mostly, they are halogenated with bromine [13] or chlorine [14], with broad bioactivities like antimicrobial [13], feeding deterrent [13], antioxidant [13,14], anticancer [13,14], relaxant (muscle relaxant and neurogenic relax-ant) [16], neuroprotective [17], and Leishmania donovani inhibitory acitivities [15].…”
Section: Resultssupporting
confidence: 81%
See 1 more Smart Citation
“…All the spectroscopic data of the known structures 2,2′methylenebis(3-methylphenol) (8), 6-methylsaligenin (9), (3-hydroxy-1,2-phenylene)dimethanol (10), and 3-(hydroxymethyl)- 2-(methoxymethyl)phenol (11) were consistent with those reported in the literature [9][10][11][12]. Although the mouse lymphocytic leukemia cell line (P388) was used to screen the extract, the cytotoxic potential of compounds 1-7 were evaluated against three selected human-originated cell lines (HeLa, HL-60, and HCT-116 cell lines) (l " [13], microorganisms [14,15], and terrestrial plants [16][17][18][19][20][21]. Mostly, they are halogenated with bromine [13] or chlorine [14], with broad bioactivities like antimicrobial [13], feeding deterrent [13], antioxidant [13,14], anticancer [13,14], relaxant (muscle relaxant and neurogenic relax-ant) [16], neuroprotective [17], and Leishmania donovani inhibitory acitivities [15].…”
Section: Resultssupporting
confidence: 81%
“…Although the mouse lymphocytic leukemia cell line (P388) was used to screen the extract, the cytotoxic potential of compounds 1-7 were evaluated against three selected human-originated cell lines (HeLa, HL-60, and HCT-116 cell lines) (l " [13], microorganisms [14,15], and terrestrial plants [16][17][18][19][20][21]. Mostly, they are halogenated with bromine [13] or chlorine [14], with broad bioactivities like antimicrobial [13], feeding deterrent [13], antioxidant [13,14], anticancer [13,14], relaxant (muscle relaxant and neurogenic relax-ant) [16], neuroprotective [17], and Leishmania donovani inhibitory acitivities [15]. Structurally, they feature a variety of benzyl monomers and oligomers including the dimers, trimers, and tetramers, which are joined by the linkage of the two carbons of C-7/ C-4′ or sometimes through an ether bond between C-7 and C-4′.…”
Section: Resultsmentioning
confidence: 99%
“…13 C NMR δ: 65.6 (C‐3), 81.2 (C‐5), 134.7 (C‐6), 129.9 (C‐7), 78.5 (C‐8), 131.4 (C‐22), 134.2 (C‐23). It has been isolated from the mushroom Lentinus edodes (Shiitake) and from the ascomycete Geosmithia lavendula . In addition, ergosta‐6,22‐diene‐3β,5α,8α‐triol has been identified in roots of Trichosanthes kirilowii and Trichosanthes baviensis leaves .…”
Section: Resultsmentioning
confidence: 99%
“…Gentisyl alcohol has also been previously isolated from marine-derived fungal microbes Penicillium terrestre, Penicillium vulpinum, Penicillium commune, Aspergillus varians, P. herbarum, Dothideomycete sp., and Geosmithia longdonii [25,[73][74][75][76][77][78].…”
Section: Pirg Percentage Inhibition In Radial Growthmentioning
confidence: 99%