Antimalarial compounds from <i>Kniphofia foliosa</i> roots

Wube, Abraham Abebe; Bučar, Franz; Asres, Kaleab; Gibbons, Simon; Rattray, Lauren; Croft, Simon L.

doi:10.1002/ptr.1635

Cited by 49 publications

(44 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Traditionally used medicinal plants have played important role in malaria treatment in most African countries including Ethiopia (Wube et al, 2005;Hilou et al, 2006). Previous ethnobotanical studies (Gessler et al, 1995;Willcox and Bodeker, 2004;Wright, 2005) revealed that several plant species contain antimalarial compounds (Wright, 2005).…”

Section: Introductionmentioning

confidence: 99%

Ethnobotanical study of antimalarial plants in Shinile District, Somali Region, Ethiopia, and in vivo evaluation of selected ones against Plasmodium berghei

Mesfin

Giday

Animut

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Ethnobotanical study of antimalarial plants in Shinile District, Somali Region, Ethiopia, and in vivo evaluation of selected ones against Plasmodium berghei

Mesfin

Giday

Animut

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…Previously, related bianthrones were isolated from the roots of Kniphofia foliosa and showed in vitro activity comparable to that of chloroquine. 27) Compounds 2, 4, 6, 8, 10 and 12 were also tested against the cholinesterase family of enzymes consisting of AChE and BChE which represent the most attractive target for drug design and discovery of mechanism-based inhibitors for the 224 Vol. 56, No.…”

mentioning

confidence: 99%

Anti-plasmodial and Cholinesterase Inhibiting Activities of some Constituents of Psorospermum glaberrimum

et al. 2008

View full text Add to dashboard Cite

Malaria is still the most devastating parasitic disease in the world, causing 2-3 million deaths every year, mostly among children under five years old and pregnant women. Africa accounts for over 90% of malaria mortality. 1) In the last decades resistance of Plasmodium falciparum, the causative agent of the most severe form of the disease, to several antimalarials, especially chloroquine and antifolates, became widely disseminated, while the cost of effective treatment is prohibitive for the large majority of the populations. For these reasons, new effective and affordable antimalarials are urgently needed.2) In Africa and elsewhere, the use of indigenous plants plays an important role in malaria treatment. 3)These plants are indeed an interesting source of new antiplasmodial compounds perhaps with new mechanisms of action.Psorospermum glaberrimum HOCHR. (Hypericaceae) is a small-to medium-sized shrub (up to 3 m high) distributed in tropical regions. Leaves and bark extracts of this plant are used in traditional medicine for the treatment of several diseases across Africa.4) The decoctions of leaves and bark are used to treat epilepsy, respiratory affections and external uses for skin diseases and leprosy. The extracts of the root bark are used for the treatment of severe cases of malaria. The pulped roots and bark extracts and the bark red resin powdered with dried leaves are remedies used externally for skin diseases and leprosy. The boiled bark gives a soapy product that is mixed with oil to rub on the skin or applied to sores for animals to keep away flies that cause scabies.4) Previous phytochemical investigations of Psorospermum species reported the presence of bioactive xanthones, anthraquinones, vismiones and psorolactones.5-16) Although some phytochemical studies have been carried out on P. glaberrimum, to the best of our knowledge, no investigation has been reported on its anti-plasmodial activity and inhibitory properties towards acetyl-and butyrylcholinesterase (AChE and BChE). AChE and BChE have been identified as attractive targets in the treatment of Alzheimer's dementia, myasthenia gravis, glaucoma, and in the recovery of victims of nerve agent exposure. Any chemical that inhibits cholinesterase activity increases the availability of acetylcholine to sustain nerve cell communications.17) Hence, cholinesterase inhibitors act as potential leads in drug discovery for nervous-system disorders.In our continuing interest in new bioactive metabolites from Cameroonian medicinal plants, we investigated the hexane extract of stem bark of P. glaberrimum which showed potent anti-plasmodial activity against the W2 strain of P. falciparum, and good AChE and BChE inhibition in vitro. In this paper, we report on the isolation and structure elucidation of a new bianthrone derivative 1, the 13 C-NMR data of the known bianthrone A2b (11) together with the anti-plasmodial and cholinesterase inhibiting activities of the isolated compounds. Results and DiscussionThe air dried stem bark of P. glaberrimum was extracted...

show abstract

“…Previously, in Ethiopia, low-lands have always been regarded as areas of high malaria transmission yet nowadays this appears to be changing, and highlands, where a large proportion of the population lives, are also becoming malaria epidemic areas (4). Accordingly, it is estimated that about three-fourths of the land is malarious (5).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of In vivo Antimalarial Activities of leaves of Moringa oleifera against Plasmodium berghei in Mice

Mulisa

Girma

Tesema

et al. 2018

Jundishapur J Nat Pharm Prod

View full text Add to dashboard Cite

Background: In addition to resistance against drugs, no new drugs have reached the market during the last decade for malaria treatment. This implies the urgent need to search for new drugs from different sources. Medicinal plants are one of such sources for novel drugs. Therefore, the aim of the current study was to investigate antimalarial activity of crude extract of leaves of Moringa oleifera Lam (Moringaceae) in Plasmodium berghei in a mice model. Methods:The acute toxicity test was used as per standard guidelines. To determine parasite inhibition, 4-day Peter's suppressive test was done. Curative and prophylactic tests were done by applying standard methods. Windows SPSS version 16 was used to analyse the data and analysis of variance (ANOVA) followed by Post Hoc Tukey's HSD to compare results between groups. Results: Death was not observed up to a dose of 2000 mg/kg of the plant extract. In all mice treated with the extract, the level of parasitaemia was significantly reduced in comparison with the control group (P < 0.001) and also a very significant difference was observed in comparison with the chloroquine treated group (P < 0.0001) with lower doses. Mean survival time was significantly increased at all treatment doses. It reduced parasitemia in a dose-dependent manner in both curative and prophylactic activity tests resulting in a significant (P < 0.05) reduction of parasitaemia in comparison with the control group. Conclusions:The result of the current study revealed that the extract possessed significant anti-plasmodial activity as displayed by its ability to suppress P. berghei infection in mice. The present study can be considered as confirmation for traditionally claimed use of the plant against malaria treatment.

show abstract

Antimalarial compounds from Kniphofia foliosa roots

Cited by 49 publications

References 9 publications

Ethnobotanical study of antimalarial plants in Shinile District, Somali Region, Ethiopia, and in vivo evaluation of selected ones against Plasmodium berghei

Ethnobotanical study of antimalarial plants in Shinile District, Somali Region, Ethiopia, and in vivo evaluation of selected ones against Plasmodium berghei

Anti-plasmodial and Cholinesterase Inhibiting Activities of some Constituents of Psorospermum glaberrimum

Evaluation of In vivo Antimalarial Activities of leaves of Moringa oleifera against Plasmodium berghei in Mice

Contact Info

Product

Resources

About