Antimalarial endoperoxides: synthesis and implications for the mode of action

Abstract

2 has been applied in probing the bonds of the endoperoxide moiety and the bonds of the rings owing to the presence of the O-O, the C-O, the O-O-C as well as the C=O modes in the spectrum. The endoperoxide moiety is especially useful in this regard because the homolytic cleavage of the O-O bond can be characterized and hence can be used to assess the vibrational properties of the O-and C-centered radicals and subsequently that of the C-C bond cleavage. The cleavage of the O-O bond, and the ability to correlate vibrational properties of the reaction products with structural properties of the isolated products suggest that infrared spectroscopy is an appropriate tool to study the mode of action of antimalarial endoperoxides.

Effect of Ozone on the Stability of Solution-Processed Anthradithiophene-Based Organic Field-Effect Transistors

“…9 The rise in the overall background signal below 1000 cm −1 after ozone exposure can be attributed to the formation of O−O bonds belonging to endoperoxide groups. 10 The breadth of these newly formed peaks could collectively increase the magnitude of the background signal when it is superimposed on the already existing signals.…”