Antimalarial substances. 26. Folate antagonists. 4. Antimalarial and antimetabolite effects of 2,4-diamino-6-[(benzyl)amino]pyrido[2,3-d]pyrimidines

Abstract

and the quinine equiv Q (the ratio of the SD90 of quinine-HC1 to the SD90 of the test substance under comparable exptl conditions). 2,4-Diamino-6- [(benzyl)aminb] pyrido [2,3-d]pyrimidine (Via) and 2 ,4-diamino-6-[(3,4-dichlorobenzyl)amino] pyrido [2,3-d] pyrimidine (VIb) lacked significant antimalarial effects at daily doses of 325 and 171 mg/kg, respectively, and were therefore <20 times as potent as the corresponding quinazoline analog 2,4-diamino-6-[(3,4-dichlorobenzyl)amino] quinazoline (la).2 2,4-Diamino-6-[(3,4-dichlorobenzyl)nitrosamino] pyrido [2,3-d]

Synthesis and Biological Evaluation of some Novel Pyrano[2,3-<i>d</i>]Pyrimidine Derivatives

“…If pyrano [2,3-d]pyrimidine moieties are clubbed into one molecule, then resultant derivative enhances its pharmaceutical activity as abundant in biologically active compounds such as antitumour [5], cardiotonic [6], antibronchitic [7] and antifungal activity [8]. Some of them exhibit antihypertensive activity [9], antimalarial [10], analgesic [10,11], and antimicrobial and antiviral evaluation [12,13] properties. Pyrano [2,3-d]pyrimidines are building blocks used to evaluate their antimicrobial activities and various derived natural products [14].…”

Two ligand oxidio-vanadium(IV) complexes as novel efficient catalysts in multicomponent reactions for synthesis of tetrahydrobenzopyran derivatives

“…These compounds are widely used as anticancer [8], antimalarial [9], antileishmanial [10], antibacterial [11], antifungal [12], antitumor [13], antianaphylactic [14], antiallergenic [15], diuretic [16] and hypotensive [17] agents. They can also be used as cognitive enhancers for the treatment of neurodegenerative disease as Alzheimer's disease, amyoprophic lateral sclerosis, Huntington's disease, Parkinson's disease, AIDS associated [18].…”

The One-Pot Synthesis of Pyrano[2,3-d]pyrimidinone Derivatives with 1,4-diazabicyclo[2.2.2]octane in Aqueous Media

“…Compounds with an uracil moiety antitumor, antibacterial, antihypertensive, vasodilator, bronchiodilator, hepatoprotective, cardiotonic, and antiallergic activities. Some of them exhibit antimalarial, antifungal analgesics, and herbicidal properties [10][11][12][13][14][15][16][17] .…”