Antimicrobial Activities of Centella asiatica Leaf and Root Extracts on Selected Pathogenic Micro-organisms

Diningrat, Diky Setya

doi:10.3923/jms.2018.198.204

Cited by 18 publications

(9 citation statements)

References 13 publications

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“…Table 1. There has also been a concordant study reporting an extensive zone of antibacterial activity obtained for the ethanol root extract of C. asiatica against S. aureus and E. coli 10 . Furthermore, reports on the plant's intense antibacterial activity of crude extracts have been registered against P. aeruginosa, E. coli, and S. aureus 15 .…”

Section: Resultsmentioning

confidence: 87%

“…Broad-spectrum antibacterial and antifungal activities of extracts of C. asiatica have previously been reported against various species of bacteria and fungi 9,10,11 . The present study was designed to experiment with the antibacterial activity of C. asiatica and compare the efficacy of aqueous, acetone and ethanol extracts of C. asiatica in inhibiting the growth of different bacteria.…”

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confidence: 99%

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2022

IJPSR

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Centella asiatica (Linn) Urban, a herb of immense medicinal properties, has been widely used by traditional healers in the treatment of skin diseases, mental fatigue, anxiety, rheumatism, eoilepsy and leprosy. In the present investigation, the antibacterial activity of ethanol, acetone and aqueous extracts of Centella asiatica were tested invitro against seven bacterial species viz. Staphylococcus aureus, Salmonella typhi, Salmonella paratyphi, Klebsiella sp., E. coli, Bacillus sp. and Pseudomonas sp. by well diffusion method. The ethanol extract inhibited the growth of Bacillus sp. and S. aureus, maximally (14 mm each), followed by that of E. coli (12 mm) and Klebsiella sp. (11 mm). The extract unaffected the growth of Salmonella typhi, Pseudomonas, and Salmonella paratyphi. The acetone extract inhibited the growth of Bacillus sp. (10 mm); the other six bacteria remained unaffected. Likewise, the aqueous extract also inhibited the growth of none of the test bacteria in this study. INTRODUCTION:Centella asiatica (L) Urban, a perennial herbaceous creeper, is an important medicinal herb belonging to Umbelliferae. The plant is commonly known as 'mandukparni', 'Indian pennywort', and jalabrahmi'. Centella asiatica is found in moist, damp places in tropical and subtropical countries, including parts of India,

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Section: Resultsmentioning

confidence: 87%

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confidence: 99%

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2022

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“…C. asiatica has effective antihypertensive, nootropic, neuroprotective, cardioprotective, antimicrobial, and anticancer activities in preclinical studies [17]. Nasution et al [18] depicted that C. asiatica root demonstrated a strong inhibitory effect than the leaf. Prakash et al [19] observed that petroleum ether, ethanol, chloroform, n-hexane, and aqueous extract of C. asiatica showed activity against Aspergillus niger and C. albicans with a zone of inhibition of 14, 16, 13, 13, and11 mm and 13, 15, 15, 11, and 9 mm respectively.…”

Section: Resultsmentioning

confidence: 99%

“…For centuries C. asiatica work against infections and diseases, including eczema, Ulcer, diarrhea, fever, and respiratory infections [7]. The purified extract of C. asiatica leaves significantly higher amounts of centellosides and antiglycation properties [8]. In addition, for com¬plementary therapy of vascular conditions, its extract works as a suitable intervention [9].…”

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confidence: 99%

Antifungal Activity of Centella asiatica on Radial Growth of Aspergillus species

2020

Lett Appl NanoBioSci

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The study was conducted to observe the antifungal activity of Centella asiatica against Aspergillus sp. Samples were collected from the local area of the Tangail district in Bangladesh. The bread was taken for isolating Aspergillus sp. in addition, Potato dextrose agar and malt extract agar were used as a media for culture and pure culture. One control group and two sample group (1%, 5%) hydrophilic extract of C. asiatica has been used. The routine observation was done for a total of 5 days after 24 hours. After routine observation, it has noticed that colony diameter and number of colonies increased rapidly from day 1 to day 5. The fungal growth was null of 5% solution both of PDA, MEA media at the first day and these increased with rising time on 5th days there were 1900 and 1600 respectively for black species and 1500 and 2500 respectively for green sp. Whereas compared with control group the growth was measured 1000, 1200 respectively at day 1 and these increased with rising time these numbers were 4000, 4200 respectively at day 5 for black. On the other hand, at 1st day the growth was measured 1100, 1200 respectively and these increased with rising time on 5th days there were 4200, 4300 respectively for green sp. However, at the end of the study, a remarkable change was observed between the control group and sample group after 1st, 2nd, 3rd, 4th and 5th days. Finally, the study showed that the bioactive compounds of C. asiatica are a potential source of preservative that inhibits the growth of fungus.

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“…Pegagan leaves are known to have activity as an anti-inflammatory (Ratz-Łyko et al, 2016), neuroprotective (Khan and Orhan, 2012), wound healing (Irhan et al, 2019), antioxidant (Park et al, 2017), urinary tract disease. respiratory disease (Chandrika and Kumara 2015), skin diseases (Bylka et al, 2014), antibacterial (Nasution et al, 2018), etc. The pharmacological activity of pegagan leaves is related to their secondary metabolites.…”

Section: Introductionmentioning

confidence: 99%

Development of Nanoparticles Pegagan Leaves Ethanolic Extract (centella asiatica (L.) Urban) using Variation Concentration of Poly-Lactic-CO-Glycolic Acid (PLGA) Polymer

2022

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Pegagan is a plant that plays an important role in health because of its secondary metabolite. However, many secondary metabolites tend to be unstable when exposed to UV light and oxygen such as flavonoid and terpenoid. The purpose of this study was to formulate the ethanolic extract of pegagan leaves into nanoparticle preparations to increase the stability of the extract. Nanoparticle preparations were made using the emulsion solvent evaporation method using Poly-Lactic-Co-Glycolic Acid (PLGA) and polyvinyl alcohol (PVA). PLGA acts as a polymer that will coat the extract and PVA as a stabilizer. Variations in the concentration of PLGA used were 50 mg, 75 mg, and 100 mg, while the concentration of PVA used was 40 mg and the extract concentration was 158 mg. Determination of the best formula is done by looking at the results of the percent encapsulation efficiency obtained from the three formulas, namely 93.68%, 85.35%, and 88.76%, respectively. Based on these results, formula 1 was determined as the best formula. The particle size obtained in the best formula was 288.1667±3.4195 nm, the polydispersity index (PDI) was 0.371±0.0045 and the zeta potential value was -10.6333±0.1154. A physical stability test (cycling test method) of the best formula found a decrease in pH of 0.54 and no organoleptic changes or precipitate formed.

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Antimicrobial Activities of Centella asiatica Leaf and Root Extracts on Selected Pathogenic Micro-organisms

Cited by 18 publications

References 13 publications

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Untitled

Antifungal Activity of Centella asiatica on Radial Growth of Aspergillus species

Development of Nanoparticles Pegagan Leaves Ethanolic Extract (centella asiatica (L.) Urban) using Variation Concentration of Poly-Lactic-CO-Glycolic Acid (PLGA) Polymer

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