Antimicrobial Activities of Mucuna pruriens (Agbara) on Some Human Pathogens

Stanley, Mbajiuka Chinedu; Ifeanyi, Obeagu Emmanuel; Chinedum, Ochei Kingsley; Chinwe, Ifediora Afoma; Emmanuel, Okezie; Nwamaka, Odo Nkechinyelu

doi:10.9790/3008-09270913

Cited by 20 publications

(25 citation statements)

References 2 publications

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“…This microbial shift might be due to the presence of huge numbers of chemically diverse and biologically active ingredients [13] in neem and acemannan, the polysaccharides in A. vera [14]. The results are in agreement with Mohammadmehdi and Jamshid [15] who also reported increased Lactobacillus spp.…”

Section: Discussionsupporting

confidence: 81%

Efficacy of early chick nutrition with Aloe vera and Azadirachta indica on gut health and histomorphometry in chicks

Shunmugaperumal¹,

Abhinaya²,

Sunder³

et al. 2017

Vet World

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Aim:This study was conducted with an aim of studying the efficacy of water supplements of Aloe vera and Azadirachta indica (neem) during pre-starter age (0-2 weeks) on gut health and histomorphometry in Vanaraja chicks.Materials and Methods:A total of 192 day old Vanaraja chicks were randomly assigned to one of four herbal water treatments throughout the experimental pre-starter stage (0-2 weeks) in a completely randomized design. Each treatment was given four replicates consisting of 12 chicks per replicate. Water treatments comprised T1: Control with regular antibiotic supplement, T2: 3 ml Aloe juice per chick per day, T3: 3 ml neem extract per chick per day, T4: 1.5 ml Aloe and 1.5 ml neem per chick per day. Gut culture was done for Escherichia coli and Lactobacillus sps. and gut histomorphometry in 24 gut samples at 14 days of age.Results:This study revealed that supplementation of A. vera and neem in water significantly (p<0.05) reduced and increased the number of gut E. coli and Lactobacillus sps. Colonies, respectively, as compared to that of control groups; Villi was significantly (p<0.05) taller and broader on 14 days of age across the jejunum of chicks fed with neem supplementation as compared to that of control chicks. Significantly lower crypt depth (p<0.05) was observed in the duodenum of Aloe supplementation. Villus height: Crypt depth ratio of duodenum and jejunum was significantly (p<0.05) increased neem and Aloe supplementation in chicks as compared to their combination and control.Conclusion:Immediate post hatch supplementation of Aloe juice and neem extract in chicks improved the development and health of their gut.

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Section: Discussionsupporting

confidence: 81%

Efficacy of early chick nutrition with Aloe vera and Azadirachta indica on gut health and histomorphometry in chicks

Shunmugaperumal¹,

Abhinaya²,

Sunder³

et al. 2017

Vet World

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“…Cheng et al [ 97 ] observed that aloe-emodin and further anthraquinone derivates coexisting with aloe emodin were more soluble in ethanol and methanol compared to water. Stanley et al [ 98 ] extracted AV gel with methanol and tested the filtrates against E. coli , S. aureus and C. albicans . Only E. coli was inhibited by the AV extract, while the other microorganisms were resistant [ 98 ].…”

Section: Discussionmentioning

confidence: 99%

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

2020

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Antibiotic resistance is an eminent threat for the survival of mankind. Nosocomial infections caused by multidrug resistant microorganisms are a reason for morbidity and mortality worldwide. Plant-based antimicrobial agents are based on synergistic mechanisms which prevent resistance and have been used for centuries against ailments. We suggest the use of cost-effective, eco-friendly Aloe Vera Barbadensis Miller (AV)-iodine biomaterials as a new generation of antimicrobial agents. In a facile, one-pot synthesis, we encapsulated fresh AV gel with polyvinylpyrrolidone (PVP) as a stabilizing agent and incorporated iodine moieties in the form of iodine (I2) and sodium iodide (NaI) into the polymer matrix. Ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) verified the composition of AV-PVP-I2, AV-PVP-I2-NaI. AV, AV-PVP, AV-PVP-I2, AV-PVP-I2-NaI, and AV-PVP-NaI were tested in-vitro by disc diffusion assay and dip-coated on polyglycolic acid (PGA) sutures against ten microbial reference strains. All the tested pathogens were more susceptible towards AV-PVP-I2 due to the inclusion of “smart” triiodides with halogen bonding in vitro and on dip-coated sutures. The biocomplexes AV-PVP-I2, AV-PVP-I2-NaI showed remarkable antimicrobial properties. “Smart” biohybrids with triiodide inclusions have excellent antifungal and promising antimicrobial activities, with potential use against surgical site infections (SSI) and as disinfecting agents.

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“…C. albicans used in this study was a pure strain of American Type Culture Collection 10231™. The use of seed stock minimizes the subculture method and has good protective and storage protocols for maintaining the safety and effectiveness of the culture [12]. C. albicans ATCC 10231 is a purified C. albicans laboratory subculture that can grow as a biofilm and has been widely used as a representative strain in clinical and laboratory studies [10,13,14].…”

Section: Methodsmentioning

confidence: 99%

Antifungal Effects of Aloe Vera Irrigant on Candida Albicans Biofilm

Astinah

Nazar

Meidyawati³

2019

Int J App Pharm

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Objective: Candida albicans tolerates unfavorable environmental conditions by forming biofilms, which can cause problems following endodontictreatments. C. albicans is the most common fungus found in failed root canals. Using natural irrigants with good antifungal properties for use assynthetic irrigant alternatives during root canal cleaning and shaping is very important. This study aimed to analyze the effects of Aloe vera onC. albicans biofilm.Methods: C. albicans biofilm was divided into the following five groups: Group I, no treatment (control group); Groups II, III, and IV, A. vera with aconcentration of 100%, 75%, and 50%, respectively; and Group V, Ethylenediaminetetraacetic acid (EDTA) 17%.Results: The average biofilm colony count for C. albicans for the A. vera 100%, 75%, and 50% groups was higher than that for the EDTA 17% groupbut lower than that for the control group.Conclusion: A. vera has antifungal effects on C. albicans biofilm, with the greatest effect occurring at 75% concentration.

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Antimicrobial Activities of Mucuna pruriens (Agbara) on Some Human Pathogens

Cited by 20 publications

References 2 publications

Efficacy of early chick nutrition with Aloe vera and Azadirachta indica on gut health and histomorphometry in chicks

Efficacy of early chick nutrition with Aloe vera and Azadirachta indica on gut health and histomorphometry in chicks

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

Antifungal Effects of Aloe Vera Irrigant on Candida Albicans Biofilm

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