Antimicrobial Activity Evaluation of Cassia spectabilis Leaf Extracts

Nagendran, K.; Ramanathan, Surash; Sasidharan, Sreenivasan; Murugaiyah, Vikneswaran; Mansor, Sharif Mahsufi

doi:10.3923/ijp.2010.510.514

Cited by 39 publications

(28 citation statements)

References 14 publications

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“…According to Krishnan et al. ( 2010 ), antibacterial extracts or compounds are categorized into two classes: bacteriostatic (MBC/MIC ratio >4) and bactericidal (MBC/MIC ratio ≤4). Following this classification, hexane extract of Mentha arvensis with MBC/MIC ratio above 61.7 was bacteriostatic for MRSA; this extract was bacteriostatic for E. coli and bactericidal for A. baumannii .…”

Section: Resultsmentioning

confidence: 99%

Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh

Hossan

Jindal

Maisha

et al. 2018

Pharmaceutical Biology

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Context: The resistance of bacteria to antibiotics is raising serious concern globally. Asian medicinal plants could improve the current treatment strategies for bacterial infections. The antibacterial properties of medicinal plants used by the Khyang tribe in Bangladesh have not been investigated.Objective: The present study examines the antibacterial properties of 18 medicinal plants used by the Khyang tribe in day-to-day practice against human pathogenic bacteria.Materials and methods: Leaves, bark, fruits, seeds, roots and rhizomes from collected plants were successively extracted with hexane, ethyl acetate and ethanol. The corresponding 54 extracts were tested against six human pathogenic bacteria by broth microdilution assay. The antibacterial mode of actions of phytoconstituents and their synergistic effect with vancomycin and cefotaxime towards MRSA was determined by time-killing assay and synergistic interaction assay, respectively.Results and discussion: Hexane extract of bark of Cinnamomum cassia (L.) J. Presl. (Lauraceae) inhibited the growth of MRSA, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii with MIC values below 100 µg/mL. From this plant, cinnamaldehyde evoked at 4 × MIC in 1 h an irreversible decrease of MRSA count Log10 (CFU/mL) from 6 to 0, and was synergistic with vancomycin for MRSA with fractional inhibitory concentration index of 0.3.Conclusions: Our study provides evidence that the medicinal plants in Bangladesh have high potential to improve the current treatment strategies for bacterial infection.

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Section: Resultsmentioning

confidence: 99%

Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh

Hossan

Jindal

Maisha

et al. 2018

Pharmaceutical Biology

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“…In addition to this, the higher vapor pressure of methanol allows the cavitational bubbles formed as a result of its low viscosity, to require less force to collapse, hence less energy is released to disrupt plant tissue [21]. Methanol has a low viscosity compared to water which eases the diffusion of methanol into the pores of the plant materials to extract the compound more effectively compared to other extraction solvent which have the same polarity [22]. Generally, the percentage yield of C. odontophyllum leaves decreased in the following order; methanol > water > acetone > hexane.…”

Section: Discussionmentioning

confidence: 99%

Phytoconstituent Screening and Antibacterial Activity of the Leaf Extracts from <i>Canarium odontophyllum</i> Miq.

Basri¹,

Nor²

2014

AJPS

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Canarium odontophyllum is one of the underutilized fruits among the local community in Sarawak, Malaysia. The leaf extracts from C. odontophyllum (6.25 mg/ml to 50 mg/m) were screened against two Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus) and two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). Extraction of the C. odontophyllum leaves using methanol produced the highest yield (5.46%) followed by water (4.0%) and acetone (2.83%) whereas hexane extracted the lowest yield (0.98%). Out of the four bacterial species tested, only S. aureus was found to be susceptible towards the C. odontophyllum leaves extract. Screening result using agar well diffusion method showed that the antimicrobial activity of the acetone and methanol extracts from C. odontophyllum leaves was concentration-dependent towards the growth inhibition of S. aureus. The MIC values for both MeOH and acetone extracts were 0.391 mg/ml. The MBC value of MeOH extract was twice its MIC value whereas the MBC and MIC values of acetone extract against S. aureus were the same. Phytochemical analysis showed that acetone, MeOH and water extracts contain flavonoid, tannin, terpenoid and phenol. These findings conclude that the leaves of C. odontophyllum may contain therapeutically-useful compounds against S. aureus, which are mostly concentrated in the acetone extract. As such, C. odontophyllum have the potential to be developed as an alternative treatment against Staphylococcus aureus-associated skin and soft tissue infections.

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“…Biological studies with extracts from Senna species (specially S. carnaval, S. excelsa and S. spectabilis) have shown a number of relevant effects, such as antimicrobial, sedative, anticonvulsant, antioxidant, antinociceptive, anti-inflammatory and leishmanicidal effects. [14][15][16][17][18][19][20] In Brazil, Senna spectabilis, S. carnaval and S. excelsa are endemic species of southeast states and have been identified as important sources of piperidine alkaloids, which have demonstrated sedative, anticonvulsant, 14 antimicrobial, antioxidant, 21 anti-inflammatory 22 and central nervous system effects, 20,23 including the inhibition of acetylcholinesterase and central analgesia. Recently, antiparasitic activity was also reported against Leishmania major promastigotes of the crude extract, fractions and a mixture of the two major alkaloids (À)-cassine/(À)-spectaline (C/E) from flowers of S. spectabilis.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of the schistosomicidal effect of the extracts, fractions and major 3-hydroxy-2,6-dialkyl-substituted piperidine alkaloids from the flowers of Senna spectabilis (Fabaceae)

Castro

Silva

et al. 2016

Bioorganic & Medicinal Chemistry Letters

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In this work, we present the in vitro schistosomicidal activity evaluation of the most active dichloromethane fraction (FDm) (ED50=83.5μg/mL) and of a mixture of the major alkaloids ((-)-cassine/(-)-spectaline, C/E) (ED50=37.4μg/mL) from the flowers of Senna spectabilis against adult worms and cercariae. We also demonstrate other toxic effects including paralysis of the adult worms, inhibition of the secretory activity, tegument lesions and cercaricidal activity. In the association test of Praziquantel (PZQ)-C/E, we observed up to 80% mortality of Schistosoma mansoni in comparison to PZQ monotherapy. Due to the diversity of the toxic effects, the schistosomicidal activity of C/E is likely a result of a multitarget mechanism involving the tegument, secretory system and neuromotor action.

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Antimicrobial Activity Evaluation of Cassia spectabilis Leaf Extracts

Cited by 39 publications

References 14 publications

Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh

Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh

Phytoconstituent Screening and Antibacterial Activity of the Leaf Extracts from <i>Canarium odontophyllum</i> Miq.

In vitro evaluation of the schistosomicidal effect of the extracts, fractions and major 3-hydroxy-2,6-dialkyl-substituted piperidine alkaloids from the flowers of Senna spectabilis (Fabaceae)

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Antimicrobial Activity Evaluation of Cassia spectabilis Leaf Extracts

Cited by 39 publications

References 14 publications

Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh

Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh

Phytoconstituent Screening and Antibacterial Activity of the Leaf Extracts from &lt;i&gt;Canarium odontophyllum&lt;/i&gt; Miq.

In vitro evaluation of the schistosomicidal effect of the extracts, fractions and major 3-hydroxy-2,6-dialkyl-substituted piperidine alkaloids from the flowers of Senna spectabilis (Fabaceae)

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Phytoconstituent Screening and Antibacterial Activity of the Leaf Extracts from <i>Canarium odontophyllum</i> Miq.