Antimicrobial activity of catechol functionalized-chitosan versus Staphylococcus epidermidis

Amato, A.; Migneco, Luisa Maria; Martinelli, Andrea; Pietrelli, Loris; Piozzi, Antonella; Francolini, Iolanda

doi:10.1016/j.carbpol.2017.09.073

Cited by 87 publications

(61 citation statements)

References 47 publications

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“…Also, alginate, a carboxyl methyl derivative of chitosan with varying degrees of efficiency was reported to inhibit biofilm formation in pathogens [18]. However, the antibiofilm effect of CFA observed in our study is more effective compared to the antibioiflm property reported for catechol derivatives of chitosan against S. epidermidis biofilms [19]. …”

Section: Discussionmentioning

confidence: 54%

Antibacterial and Biofilm Modulating Potential of Ferulic Acid-Grafted Chitosan against Human Pathogenic Bacteria

Dasagrandhi

Park

Jung

et al. 2018

IJMS

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The emergence of more virulent forms of human pathogenic bacteria with multi-drug resistance is a serious global issue and requires alternative control strategies. The current study focused on investigating the antibacterial and antibiofilm potential of ferulic acid-grafted chitosan (CFA) against Listeria monocytogenes (LM), Pseudomonas aeruginosa (PA), and Staphylococcus aureus (SA). The result showed that CFA at 64 µg/mL concentration exhibits bactericidal action against LM and SA (>4 log reduction) and bacteriostatic action against PA (<2 log colony forming units/mL reduction) within 24 h of incubation. Further studies based on propidium iodide uptake assay, measurement of material released from the cell, and electron microscopic analysis revealed that the bactericidal action of CFA was due to altered membrane integrity and permeability. CFA dose dependently inhibited biofilm formation (52–89% range), metabolic activity (30.8–75.1% range) and eradicated mature biofilms, and reduced viability (71–82% range) of the test bacteria. Also, the swarming motility of LM was differentially affected at sub-minimum inhibitory concentration (MIC) concentrations of CFA. In the present study, the ability of CFA to kill and alter the virulence production in human pathogenic bacteria will offer insights into a new scope for the application of these biomaterials in healthcare to effectively treat bacterial infections.

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Section: Discussionmentioning

confidence: 54%

Antibacterial and Biofilm Modulating Potential of Ferulic Acid-Grafted Chitosan against Human Pathogenic Bacteria

Dasagrandhi

Park

Jung

et al. 2018

IJMS

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“…The degree of deacetylation usually ranges from 70% to 95%. The presence of amine functional groups in the CS backbone makes CS easy modifiable by both chemical reactions and physical interactions with a number of different molecules widening its applications [12,13]. CS modification also aims at enhancing its poor mechanical properties that often makes it unusable in some fields.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of TPP-Chitosan Crosslinked Scaffolds for Tissue Engineering

et al. 2020

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Scaffolds are three-dimensional porous structures that must have specific requirements to be applied in tissue engineering. Therefore, the study of factors affecting scaffold performance is of great importance. In this work, the optimal conditions for cross-linking preformed chitosan (CS) scaffolds by the tripolyphosphate polyanion (TPP) were investigated. The effect on scaffold physico-chemical properties of different concentrations of chitosan (1 and 2% w/v) and tripolyphosphate (1 and 2% w/v) as well as of cross-linking reaction times (2, 4, or 8 h) were studied. It was evidenced that a low CS concentration favored the formation of three-dimensional porous structures with a good pore interconnection while the use of more severe conditions in the cross-linking reaction (high TPP concentration and crosslinking reaction time) led to scaffolds with a suitable pore homogeneity, thermal stability, swelling behavior, and mechanical properties, but having a low pore interconnectivity. Preliminary biocompatibility tests showed a good osteoblasts’ viability when cultured on the scaffold obtained by CS 1%, TPP 1%, and an 8-h crosslinking time. These findings suggest how modulation of scaffold cross-linking conditions may permit to obtain chitosan scaffold with properly tuned morphological, mechanical and biological properties for application in the tissue regeneration field.

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“…It might be due to many other factors affecting the inhibition rate such as sorts of bacterial strains and conditions of biological testing [66]. To expect the synergetic effect of the antimicrobial activity, the incorporation with other promising compounds [43,44,[67][68][69] and the modification of structure of chitosan molecules are attempted [26,[70][71][72]. The phytochemicals like phenolic compounds are broadly attempted to improve antimicrobial activity of chitosan by grafting into the structure [44,73].…”

mentioning

confidence: 99%

Competitive Biological Activities of Chitosan and Its Derivatives: Antimicrobial, Antioxidant, Anticancer, and Anti-Inflammatory Activities

Kim

2018

International Journal of Polymer Science

178

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Chitosan is obtained from alkaline deacetylation of chitin, and acetamide groups are transformed into primary amino groups during the deacetylation. The diverse biological activities of chitosan and its derivatives are extensively studied that allows to widening the application fields in various sectors especially in biomedical science. The biological properties of chitosan are strongly depending on the solubility in water and other solvents. Deacetylation degree (DDA) and molecular weight (MW) are the most decisive parameters on the bioactivities since the primary amino groups are the key functional groups of chitosan where permits to interact with other molecules. Higher DDA and lower MW of chitosan and chitosan derivatives demonstrated higher antimicrobial, antioxidant, and anticancer capacities. Therefore, the chitosan oligosaccharides (COS) with a low polymerization degree are receiving a great attention in medical and pharmaceutical applications as they have higher water solubility and lower viscosity than chitosan. In this review articles, the antimicrobial, antioxidant, anticancer, anti-inflammatory activities of chitosan and its derivatives are highlighted. The influences of physicochemical parameters of chitosan like DDA and MW on bioactivities are also described.

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Antimicrobial activity of catechol functionalized-chitosan versus Staphylococcus epidermidis

Cited by 87 publications

References 47 publications

Antibacterial and Biofilm Modulating Potential of Ferulic Acid-Grafted Chitosan against Human Pathogenic Bacteria

Antibacterial and Biofilm Modulating Potential of Ferulic Acid-Grafted Chitosan against Human Pathogenic Bacteria

Preparation and Characterization of TPP-Chitosan Crosslinked Scaffolds for Tissue Engineering

Competitive Biological Activities of Chitosan and Its Derivatives: Antimicrobial, Antioxidant, Anticancer, and Anti-Inflammatory Activities

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