Antimicrobial activity of extractives of Solidago microglossa

Morel, Ademir F.; Dias, Gaspari; Porto, Carla; Simionatto, Euclésio; Stüker, Caroline Z.; Dalcol, Ionara I.

doi:10.1016/j.fitote.2006.05.006

Cited by 21 publications

(14 citation statements)

References 2 publications

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“…Iron sulfate (Fe 2 SO 4 ), ascorbic acid, chloridric and acetic acid were obtained from Merck (Rio de Janeiro, RJ, Brazil). Quercitrin was isolated from Solidago microglossa D.C. and the purity of the isolated compound was 99.3% [38].…”

Section: Chemicalsmentioning

confidence: 99%

Antioxidant Effects of Different Extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus

et al. 2008

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Considering the important role of oxidative stress in the pathogenesis of several neurological diseases, and the growing evidence of the presence of compounds with antioxidant properties in the plant extracts, the aim of the present study was to investigate the antioxidant capacity of three plants used in Brazil to treat neurological disorders: Melissa officinalis, Matricaria recutita and Cymbopogon citratus. The antioxidant effect of phenolic compounds commonly found in plant extracts, namely, quercetin, gallic acid, quercitrin and rutin was also examined for comparative purposes. Cerebral lipid peroxidation (assessed by TBARS) was induced by iron sulfate (10 microM), sodium nitroprusside (5 microM) or 3-nitropropionic acid (2 mM). Free radical scavenger properties and the chemical composition of plant extracts were assessed by 1'-1' Diphenyl-2' picrylhydrazyl (DPPH) method and by Thin Layer Chromatography (TLC), respectively. M. officinalis aqueous extract caused the highest decrease in TBARS production induced by all tested pro-oxidants. In the DPPH assay, M. officinalis presented also the best antioxidant effect, but, in this case, the antioxidant potencies were similar for the aqueous, methanolic and ethanolic extracts. Among the purified compounds, quercetin had the highest antioxidant activity followed by gallic acid, quercitrin and rutin. In this work, we have demonstrated that the plant extracts could protect against oxidative damage induced by various pro-oxidant agents that induce lipid peroxidation by different process. Thus, plant extracts could inhibit the generation of early chemical reactive species that subsequently initiate lipid peroxidation or, alternatively, they could block a common final pathway in the process of polyunsaturated fatty acids peroxidation. Our study indicates that M. officinalis could be considered an effective agent in the prevention of various neurological diseases associated with oxidative stress.

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Section: Chemicalsmentioning

confidence: 99%

Antioxidant Effects of Different Extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus

et al. 2008

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“…The phytochemical study of this species demonstrated the presence of quercitrin, a glicosidic flavonoid, and also tanines, saponines, resins and essential oils in the tips, as well as inulin and rutine diterpines, quinine acid, rhamnoides and caffeic acid, chlorogenic and hydrocynamic and their derivates in the roots (Torres et al, 1989). Some studies have reported the cicatrizing and antimicrobial activity of the S. microglossa (Neto et al, 2004;Morel et al, 2006). However, there are no data in the literature, at least of our knowledge, with regard to the cytotoxicity of this medicinal plant popularly used.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic effects of infusions (tea) of Solidago microglossa DC. (Asteraceae) on the cell cycle of Allium cepa

Bagatini¹,

Fachinetto²,

Silva³

et al. 2009

Rev. bras. farmacogn.

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DC. (Asteraceae) no ciclo celular de Allium cepa". A espécie medicinal Solidago micrglossa DC., a qual é nativa da América do Sul, é usada como infusão (chá) para desordens estomacais na medicina popular. O objetivo desse estudo foi avaliar o potencial efeito citotóxico dessas infusões no ciclo celular de Allium cepa. Folhas in natura de três populações dessa espécie foram utilizadas no preparo das infusões em duas concentrações: 1,75 mg/mL e 14 mg/mL. Células de raízes de cebola (Allium cepa) foram usadas como sistema teste nos ensaios in vivo. As lâminas foram feitas através da técnica de esmagamento. As células foram analisadas em todos os ciclos celulares de A. cepa, totalizando 6000 células para cada grupo de bulbos. O índice mitótico (IM) foi calculado e a análise estatística foi realizada através do teste Qui-quadrado (χ 2 = 0,05). Os resultados mostraram que as infusões de S. microglossa na maior concentração (14 mg/mL) causou uma redução no IM comparado com os controles nas populações estudadas. Nas concentrações comumente usadas pelas pessoas houve um aumento significativo do IM em relação ao controle nas populações 1 e 3 e foi reduzido na população 2. Em conclusão, infusões de S. microglossa apresentam efeito antiproliferativo na maior concentração testada.Unitermos: Sistema teste vegetal, planta medicinal, citotóxico, Solidago microglossa, Asteraceae. ABSTRACT:The medicinal specie Solidago microglossa DC., which is native from South America, is used as infusion (tea) for stomach disorders in popular medicine. This study aimed to evaluate the potential cytotoxic effect of these infusions on the cell cycle of Allium cepa. In natura leaves of three populations of this species were used in preparing infusions at two concentrations: 1.75 mg/mL and 14 mg/mL. Onion (Allium cepa) root-tip cells were used as test system in in vivo assays. Slides were done through smashing technique. Cells were analyzed in all cell cycles of A. cepa, totalizing 6000 cells for each group of bulbs. The mitotic index (MI) was calculated, and the statistical analysis was carried out through the Chi-square test (χ 2 = 0.05). The results show that the infusions of S. microglossa at a highest concentration (14 mg/mL) caused a significant reduction in the MI compared with control in the studied populations. In concentrations commonly used by people there was a significant increase of MI in relation to controlled populations 1 and 3 and a decrease in population 2. In conclusion, infusions of S. microglossa presented antiproliferative effect at a highest concentration.

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“…Only diterpenes, substances protecting against gastric lesions, were isolated from the roots [35][36][37]. Morel et al [38] reported the use of Solidago leaves as gastrointestinal stimulant and healing and anti-inflammatory agent. Facury Neto et al [39] observed minimal, but significant, effects on wound healing in rats.…”

Section: Introductionmentioning

confidence: 99%

InGaP 670-nm laser therapy combined with a hydroalcoholic extract of Solidago chilensis Meyen in burn injuries

Catarino¹,

Godoy²,

Scharlack³

et al. 2015

Lasers Med Sci

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Therapies that accelerate the healing of burn injuries, improving the quality of life of the patient and reducing the cost of treatment are important. This study evaluated the effects of InGaP 670-nm laser therapy combined with a hydroalcoholic extract of Solidago chilensis leaves on burn wound healing in rats. Seventy-two rats were divided randomly into four groups: control untreated (C), treated with InGaP 670-nm laser with power density of 0.41 W/cm(2) and energy density of 4.93 J/cm(2) (L), treated with S. chilensis extract (S) and treated with S. chilensis extract and laser (LS). Second-degree burns were produced on the back of the animals with metal plate. Wound samples were collected on days 7, 14 and 21 of treatment for structural analysis, morphometry and Western blotting to quantify the expression of transforming growth factor beta 1 (TGF-β1) and vascular endothelial growth factor (VEGF). The results showed that InGaP laser irradiation at 670 nm alone and combined with extract of S. chilensis promoted significant tissue repair responses in this experimental model, increasing the number of fibroblasts, collagen fibres and newly formed blood vessels throughout the experimental period and decreasing the number of granulocytes in burn wounds of second degree in all treated groups. Exclusive treatment of burn wounds with the hydroalcoholic extract of S. chilensis provided similar quantitative results to those seen in the untreated group throughout the experimental period. Therefore, it was observed in the L and LS groups different responses in the expression of TGF-β1 and VEGF. The application of 670-nm laser alone or combined with the extract of S. chilensis promoted favourable responses in tissue repair of second-degree burns in this experimental model.

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Antimicrobial activity of extractives of Solidago microglossa

Cited by 21 publications

References 2 publications

Antioxidant Effects of Different Extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus

Antioxidant Effects of Different Extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus

Cytotoxic effects of infusions (tea) of Solidago microglossa DC. (Asteraceae) on the cell cycle of Allium cepa

InGaP 670-nm laser therapy combined with a hydroalcoholic extract of Solidago chilensis Meyen in burn injuries

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