Antimicrobial Activity of Gotu Kola (Centella asiatica) Leaf Extract as an Alternative to Herbal Beverage

Abstract

Pathogenic microorganisms include Aspergillus sp., Escherichia coli and Staphylococcus aureus. Antibiotic administration during the treatment of contagious illnesses may cause bacterial resistance. Treatment with herbal medicine, made from natural ingredients, is an option to prepare for this. A plant known as gotu kola (Centella asiatica) has the capacity to become a herbal beverage. The intention of this research was to discover whether gotu kola leaves, a herbal beverage, had any antimicrobial properties. This study was categorized as an experimental study with an entirely random approach. This study performing an analysis of variance on the data, the Duncan's Multiple Range Test was conducted. The findings demonstrated that Staphylococcus aureus and Escherichia coli bacteria could not grow when exposed to gotu kola leaf extract. Gotu kola leaf preparation has the ability to stop Staphylococcus aureus and Escherichia coli from growing. The greatest average hindrance of 9.67 ± 0.36 mm and 10.12 ± 1.12 mm against Escherichia coli and Staphylococcus aureus bacteria was obtained by 100% concentrated infusion from the leaves of gotu kola. Alkaloids, flavonoids, and tannins are examples of the gotu kola leaf extract's metabolite components that can increase the inhibitory power of the herb. However, the Aspergillus sp. in this research was not inhibited by the gotu kola extract. The body structure of the Aspergillus sp. and length of storing of the gotu kola extract are probable causes for there was not inhibitory effect.

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“…According to Soebagio et al (2020), the ethanol extract of gotu kola leaves at a concentration of 20% has an inhibition zone area against Propionibacterium acnes bacteria that has the same value as that of clindamycin (6.0755 cm2). By rebuilding skin tissue, gotu kola leaf extract can accelerate the healing of acne-related inflammation (Yoscar & Edityaningrum, 2023) caused by Staphylococcus aureus (Siregar et al, 2022), Propionibacterium acne and Staphylococcus aureus (Khairiah et al, 2020), Propionibacterium acnes and Staphylococcus aureus, Propionibacterium acnes (Jatmiko et al, 2022), Staphylococcus aureus (Fatimah et al, 2022), and Staphylococcus aureus and Escherichia coli (Wulansari et al, 2023). Research on the inhibitory activity in gotu kola plant extract (Centella asiatica (L.) Urb.)…”

REVIEW: A STUDY ON THE USE OF GOTU KOLA EXTRACT (Centella asiatica (L.) Urb.) AS A TREATMENT FOR ACNE

“…According to Soebagio et al (2020), the ethanol extract of gotu kola leaves at a concentration of 20% has an inhibition zone area against Propionibacterium acnes bacteria that has the same value as that of clindamycin (6.0755 cm2). By rebuilding skin tissue, gotu kola leaf extract can accelerate the healing of acne-related inflammation (Yoscar & Edityaningrum, 2023) caused by Staphylococcus aureus (Siregar et al, 2022), Propionibacterium acne and Staphylococcus aureus (Khairiah et al, 2020), Propionibacterium acnes and Staphylococcus aureus, Propionibacterium acnes (Jatmiko et al, 2022), Staphylococcus aureus (Fatimah et al, 2022), and Staphylococcus aureus and Escherichia coli (Wulansari et al, 2023). Research on the inhibitory activity in gotu kola plant extract (Centella asiatica (L.) Urb.)…”

Sosialisasi Potensi Daun Pegagan (Centella Asiatica) Sebagai Minuman Herbal Yang Bersifat Antibakteri Di Desa Renon

“…Ekstrak daun pegagan memiliki aktivitas antibakteri terhadap pertumbuhan Streptococcus mutans (Azzahra & Hayati, 2018). Selain itu, penelitian yang dilakukan oleh Wulansari, et al (2023) menyatakan bahwa ekstrak daun pegagan mampu menghambat pertumbuhan bakteri S.aureus dan E.coli. Adanya kandungan metabolit sekunder pada daun pegagan menyebabkan daun ini berpotensi sebagai minuman herbal.…”

“…Kemampuan antibakteri dari ekstrak daun pegagan mampu menghambat pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli. Rerata daya hambat ekstrak daun yang dihasilkan sebesar 9,67 ± 0,36 mm dan 10,12 ± 1,12 berturut-turut terhadap bakteri Staphylococcus aureus dan Escherichia coli pada konsentrasi ekstrak 100% (Wulansari et al, 2023). Kegiatan sosialisasi ini penting dilakukan guna, mengenalkan kepada masyarakat tentang potensi yang dimiliki oleh tanaman pegagan sebagai minuman herbal yang berpotensi sebagai antibakteri.…”