Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms

Huang, Chao‐Song; George, Brian C.; Ebersole, J. L.

doi:10.1016/j.archoralbio.2010.05.009

Cited by 173 publications

(117 citation statements)

References 22 publications

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“…The similarity in the results may be due to CPB and its antibacterial monomer MDPB (Imazato et al 1998). CSEB contains 10-MDP, which could have exerted an antibacterial effect (Paradella et al 2009), while the EA O tested in this study has an essential oil rich in fatty acids (Nakatsuji et al 2009;Huang et al 2010). Unpublished data showed that AP had a cytotoxic effect on fibroblasts, which could explain the antimicrobial effect observed in this study.…”

Section: Anti-biofouling Testing: Total Lactobacillisupporting

confidence: 57%

Self-etching dental adhesive containing a natural essential oil: anti-biofouling performance and mechanical properties

Peralta¹,

Carvalho²,

Sande³

et al. 2013

Biofouling

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This study assessed the anti-biofouling performance of an experimental adhesive system containing a naturally occurring essential vegetable oil and examined the following physical and mechanical properties: water sorption (WS) and solubility (SL), microtensile bond strength to dentin (μTBS), and degree of conversion. The following six groups were tested: a self-etching experimental adhesive containing refined essential oil from the seeds of the Butia capitata tree (EA O ); an oil-free version of the experimental adhesive (EA NO ); one group without adhesive as the control (C); and the three following commercial self-etching adhesives: Clearfil Protect Bond (CPB), Clearfil SE Bond, and Adper SE Plus. The antibacterial effect was estimated by microbiological culture on selective/non-selective media, and the results expressed as colony-forming units per unit weight of dry biofilm (CFU mg À1). The data were submitted to ANOVA and Tukey's post hoc test (α = 0.05). After 24 h, pH changes were similar in the storage medium of all tested adhesive systems. EA O showed similar levels of antimicrobial activity in a model biofilm microcosm as the commercial self-etching adhesive CPB. Both were effective against total microorganisms, aciduric bacteria, lactobacilli, and Streptococcus mutans. WS and SL were not affected by the presence of the essential oil; the values of EA O were similar to or less than those of commercial equivalents. The incorporation of an essential oil into an experimental adhesive did not influence its monomer conversion result. Immediate μTBS values of EA O and EA NO were similar and were greater than those of commercial equivalents. After storage for 6 months, the μTBS of the EA O decreased significantly and became similar to the values of commercial equivalents, while the strength of the EA NO was not affected.

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Section: Anti-biofouling Testing: Total Lactobacillisupporting

confidence: 57%

Self-etching dental adhesive containing a natural essential oil: anti-biofouling performance and mechanical properties

Peralta¹,

Carvalho²,

Sande³

et al. 2013

Biofouling

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“…A relative increase in oleic acid in the proximal colon of infected pigs could contribute to localized mucosal inflammation (22,23) and change the microbiome due to its antibacterial activity (9,16). A further consideration would be to determine if T. suis-induced mucosal damage in the proximal colon facilitated systemic exposure to local lipopolysaccaride, which has been shown recently to alter the oxidation of oleic acid in piglets and contribute to malabsorption by enterocytes (15).…”

Section: Discussionmentioning

confidence: 99%

Alterations in the Porcine Colon Microbiota Induced by the Gastrointestinal Nematode Trichuris suis

Li¹,

et al. 2012

Infect Immun

190

222

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ABSTRACTHelminth parasites ensure their survival by regulating host immunity through mechanisms that dampen inflammation. These properties have recently been exploited therapeutically to treat human diseases. The biocomplexity of the intestinal lumen suggests that interactions between the parasite and the intestinal microbiota would also influence inflammation. In this study, we characterized the microbiota in the porcine proximal colon in response toTrichuris suis(whipworm) infection using 16S rRNA gene-based and whole-genome shotgun (WGS) sequencing. A 21-dayT. suisinfection in four pigs induced a significant change in the composition of the proximal colon microbiota compared to that of three parasite-naive pigs. Among the 15 phyla identified, the abundances ofProteobacteriaandDeferribactereswere changed in infected pigs. The abundances of approximately 13% of genera were significantly altered by infection. Changes in relative abundances ofSuccinivibrioandMucispirillum, for example, may relate to alterations in carbohydrate metabolism and niche disruptions in mucosal interfaces induced by parasitic infection, respectively. Of note, infection byT. suisled to a significant shift in the metabolic potential of the proximal colon microbiota, where 26% of all metabolic pathways identified were affected. Besides carbohydrate metabolism, lysine biosynthesis was repressed as well. A metabolomic analysis of volatile organic compounds (VOCs) in the luminal contents showed a relative absence in infected pigs of cofactors for carbohydrate and lysine biosynthesis, as well as an accumulation of oleic acid, suggesting altered fatty acid absorption contributing to local inflammation. Our findings should facilitate development of strategies for parasitic control in pigs and humans.

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“…Increase in oleic acid levels in the colon of pigs due to presence of helminths have been observed by Knoch et al [46]. Oleic acid reportedly has antimicrobial properties [47].…”

Section: Shift In the Metabolome In The Animal Gut Due To The Presencmentioning

confidence: 89%

Helminth Infections and Gut Microbiota: The Futuristic Study of Pathogen Virulence and Gut Ecosystem

Biswal¹

2016

J Mol Biomark Diagn

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The animal gut has co-evolved with the microbes and parasites leading to an increased tolerance to their existence therein. Their peaceful co-existence has been a subject of research in the recent years to decipher their probabilities in multidimensional applications ranging from eradicating the helminths without affecting gut homeostasis or using helminths as therapeutics. Negligence in any one of the components of the animal gut can lead to unhealthy gut ecosystems often manifesting a diseased state. Supply of key nutrients, synthesis of vitamins, resistance to invasion by pathogens and helping in hatching of helminth eggs are some important services provided by the gut bacteria that may well be utilised by the helminth. The gut bacteria thus seem to be exploited by the helminths for establishment of infection in the host. However, relationships are not as simple as it seems. The paper tries to present different aspects of this host-bacteria-helminth relationship and their future perspectives.

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Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms

Cited by 173 publications

References 22 publications

Self-etching dental adhesive containing a natural essential oil: anti-biofouling performance and mechanical properties

Self-etching dental adhesive containing a natural essential oil: anti-biofouling performance and mechanical properties

Alterations in the Porcine Colon Microbiota Induced by the Gastrointestinal Nematode Trichuris suis

Helminth Infections and Gut Microbiota: The Futuristic Study of Pathogen Virulence and Gut Ecosystem

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