Antimicrobial activity of various extracts and carvacrol from Lippia multiflora leaf extract

Kunle, Olobayo O.; Okogun, Joseph I.; Egamana, E.; Emojevwe, E.; Shok, M.

doi:10.1078/094471103321648674

Cited by 59 publications

(38 citation statements)

References 7 publications

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“…Since 1-buthanol as solvent posses antimicrobial activity this result is not considered for this work. n-hexane extracts are not antimicrobial active [4].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial activity of bioactive component from flower of linum capitatum kit

Ilić¹,

Konstantinović²,

Todorović³

2004

Facta Univ Phys Chem Technol

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Abstract. Different extracts containing bioactive components and etheric oil of the flowers of Linum capitatum Kit. (Linacea) of Serbian origin were tested for an antimicrobial activity against four bacteria (Staphylococcus aureus, Escherichia coli, Bacillus subtilus, Pseudomonas aeruginosa), one mold (Aspergillus niger) and one yeast (Candida albicans). The isolated flavonoids were also tested against Staphylococcus aureus, Escherichia coli, Bacillus anhtracis, Pseudomonas aeruginosa, Aspergillus niger, Candida albicans andHerpes simplex virus type.

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“…Since 1-buthanol as solvent posses antimicrobial activity this result is not considered for this work. n-hexane extracts are not antimicrobial active [4].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial activity of bioactive component from flower of linum capitatum kit

Ilić¹,

Konstantinović²,

Todorović³

2004

Facta Univ Phys Chem Technol

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“…The dominant source of knowledge of natural product uses from medicinal plants is as a result of man experimenting by trial and error for hundreds of centuries through palatability trials or untimely deaths, searching for available foods for the treatment of diseases (Kinghorn et al, 2011). Current trends in drug development process are focused on natural sources, especially sources of plant to some proven correlation between folkloric medicinal uses of some of these plants to biological activity (Kunle et al, 2003). Ficus species contain flavanoid glycosides, alkaloids, phenolic acids, steroids, saponinscoumarins, tannins, oleanolic acid, rusolic acid, α-hydroxyursolic acid, protocatechuic acid, maslinic acid.…”

Section: Introductionmentioning

confidence: 99%

GC-MS analysis of ethyl acetate extract of <i>Ficus sycomorus</i> root Linn. (Moraceae

Abubakar¹,

Danmalam²,

Ahmed³

et al. 2017

Bayero J. Pure App. Sci.

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Gas Chromatography-Mass Spectrometry (GC chromatography of the ethyl acetate extract of Ficus sycomorus Linn. root two compounds. The mass spectral data shows that all the compounds have molecular ion peak and base peak with M/Z 468 and 218 respectively. The tentative identification was achieved by comparing their mass spectra with the data sys compounds are suggested to be pentacyclic triterpenoid isomers, and this include; 12 yl, acetate (3.alpha) and Urs-12-en sycomorus suggests that the plant conforms to other members of the genus Ficus. The result of this study shows that pentacyclic triterpenoid isomers can be useful in the chemotaxonomy of the Moraceae Family if the investigation is extended to other genera and species. Furth should be carried out to isolate the compounds in their pure forms and detail spectroscopic studies should also be carried out to fully elucidate their structures.

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“…Such antimicrobial activities could form the basis to apply the oil in food preservation and in natural therapy (Albuquerque et al, 2007). The antimicrobial activity of carvacrol is well established (Kunle et al, 2003) and this study has shown that it is a major component of Lippia gracilis Schauer. One of the important cell types that are affected by diabetes is polymorphonuclear neutrophils (PMN).…”

Section: Discussionmentioning

confidence: 99%

O oleo essencial de Lippia gracilis Schauer, Verbenaceae, em ratos diabeticos

Neto¹,

Matos²,

Andrade³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "O oleo essencial de Lippia gracilis Schauer, Verbenaceae, em ratos diabeticos". O óleo essencial das folhas de Lippia gracilis Schauer, Verbenaceae, foi examinado por CG e CG-MS. Quinze constituintes foram identificados, onde o carvacrol, p-cimeno e o γ-terpineno foram as substâncias majoritárias. No estudo in vitro, a solução a 5% do óleo de L. gracilis Schauer apresentou atividade antibacteriana para Staphylococcus aureus isolado de úlcera infectada de paciente diabético. O estudo avaliou a atividade antibacteriana da solução a 5% do óleo de L. gracilis Schauer em modelo experimental em diabetes utilizando ratos albinos Wistar machos com membro pélvico infectado com cepa de Staphylococcus aureus. No experimento foram utilizados 28 ratos Wistar distribuídos em quatro grupos (G1-branco, G2-controle negativo, G3-controle positivo, G4-teste) de sete ratos. Quando comparado o grupo G4 com G3, observou-se que a solução a 5% promoveu uma redução nas CFU/mL após 24h da administração do inóculo (S.aureus sem L. gracilis Schauer 10 8 ± 313 versus S.aureus com L. gracilis Schauer 13,28 ± 4,03). Os resultados foram expressos através do cálculo da média±EPM) e análise de variança (ANOVA). A diferença entre a concentração inibitória mínima no estudo in vitro foi determinada pelo teste Turkey (p<0.05). O teste Newman-Keuls com nível de significância (p<0.05) foi utilizado para o cálculo dos resultados obtidos no experimento in vivo. A solução a 5% do óleo essencial de Lippia gracilis Schauer apresentou boa atividade antibacteriana tanto no estudo in vivo como no in vitro.Unitermos: Lippia gracilis Schauer, Verbenaceae, alecrim-de-tabuleiro, monoterpenos, carvacrol, p-cimeno, γ-terpineneo. ABSTRACT:The essential oil from Lippia gracilis Schauer (Verbenaceae) leaves was examined by GC and GC-MS. Fifteen constituents were identified. Carvacrol, p-cymene and γ-terpinene were found to be the major components. In the in vitro study, 5% solution of the Lippia gracilis Schauer oil presented antibacterial activity against Staphylococcus aureus isolated from diabetic patients with infected ulcers. The study evaluated the antibacterial activity of the 5% solution of the Lippia gracilis Schauer oil on the experimental model of diabetic adult male albino Wistar rats with leaft pelvic limb infected by Staphylococcus aureus strain. In this experiment, 28 diabetic Wistar rats were used, randomly distributed in four different groups of seven rats, (G1-white; G2-negative control; G3-positive control and G4-test). When comparing group G4 with G3, it was observed that the 5% solution presented a reduced CFU/mL level showing the antibacterial effect of the oil 24 hours after the administration of the inoculum (S .aureus without Lippia gracilis Schauer 108 ±313 versus S.aureus with Lippia gracilis Schauer 13.28± 4.03). The results were expressed as mean±S.E.M. One-way analysis of the variance (ANOVA) was used. The differences between the minimum inhibitory concentration in vitro test were determined by the Tukey test (p<0.05). The Newma...

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Antimicrobial activity of various extracts and carvacrol from Lippia multiflora leaf extract

Cited by 59 publications

References 7 publications

Antimicrobial activity of bioactive component from flower of linum capitatum kit

Antimicrobial activity of bioactive component from flower of linum capitatum kit

GC-MS analysis of ethyl acetate extract of <i>Ficus sycomorus</i> root Linn. (Moraceae

O oleo essencial de Lippia gracilis Schauer, Verbenaceae, em ratos diabeticos

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