2022
DOI: 10.2217/fmb-2022-0085
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Antimicrobial and Antibiofilm Activities of Desloratadine Against Multidrug-Resistant Acinetobacter Baumannii

Abstract: Aim: The antimicrobial and antibiofilm activities of the antihistamine desloratadine against multidrug-resistant (MDR) Acinetobacter baumannii were evaluated. Results: Desloratadine inhibited 90% bacterial growth at a concentration of 64 μg/ml. The combination of desloratadine with meropenem reduced the MIC by twofold in the planktonic state and increased the antibiofilm activity by eightfold. Survival curves showed that combinations of these drugs were successful in eradicating all bacterial cells within 16 h… Show more

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Cited by 4 publications
(5 citation statements)
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“…It is possible that targeting their protein surfaces rather than internal cavities, resulted in too weak interactions for co-evolution (Figure S2). In this regard, collagen-Hsp47 interactions [73][74][75][76] , may be required to define a complete binding cavity, rather than only a Hsp47 surface. Additional work may help to clarify these possibilities.…”
Section: Dw-bel Of Target / Parent Pair Modelsmentioning
confidence: 99%
See 1 more Smart Citation
“…It is possible that targeting their protein surfaces rather than internal cavities, resulted in too weak interactions for co-evolution (Figure S2). In this regard, collagen-Hsp47 interactions [73][74][75][76] , may be required to define a complete binding cavity, rather than only a Hsp47 surface. Additional work may help to clarify these possibilities.…”
Section: Dw-bel Of Target / Parent Pair Modelsmentioning
confidence: 99%
“…Deep-learning screening based on experimental inhibitory training-model developed from data on the Drug Repurposing Hub library 66 , recently discovered Abaucin 67 . Abaucin, targeted LolEC, showed anti-A.baumannii activities at low µM ranges [68][69][70][71][72][73][74] and suppressed mice infection. A. baumannii is a Gram-negative multi-drug resistant bacteria causing health care-associated infections world-wide [75][76][77] with high mortality rates 78 ,69 A. baumannii needs new drug discoveries [79][80][81][82] possibly targeting the E protein as in E.coli 83 .…”
Section: Introductionmentioning
confidence: 99%
“…These amino acid preferences confirmed their higher affinity predictions towards A.baumannii E protein at the LolCE complex. Because of the implication of lethal mutants in the upper E region 16 , the similar 18544 and 34326 preferences could be implicated in experimental binding to A.baumannii LolCE to interact with its lipoprotein traffic activity.…”
Section: Chain E Chainmentioning
confidence: 99%
“…Small-molecule inhibitors of lipoprotein transport have shown antibacterial activities. However, most of present Loltargeted antibiotics, including abaucin are active against A. baumannii at low micromolar ranges 7,[12][13][14][15][16][17] . There may be room for affinity improvements.…”
Section: Introductionmentioning
confidence: 99%
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