Antimicrobial and Antifungal Activities of Quasi-Dimeric and Related Alkaloids

Caron, Catherine; Hoizey, M. J.; Men‐Olivier, L. Le; Massiot, Georges; Zèches, Monique; Choisy, Claude; Magrex, E. Le; Verpoorte, Robert

doi:10.1055/s-2006-962483

Cited by 28 publications

(12 citation statements)

References 6 publications

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“…It is evident from literature that alkaloids isolated from plants have considerable biological activity 1,2 . Similar observations were made by Caron et al 14 of indole alkaloids for their antimicrobial properties 14 and antifungal properties 15 , isolated from various Strychnos species. Further, dolichantoside and palicoside, the glucoindole alkaloids of S. melladora have shown significant antimycotic activity against Candida species 16 .…”

Section: Resultssupporting

confidence: 79%

In Vitro Antimicrobial Screening of Alkaloid Fractions from Strychnos potatorum

Mallikharjuna

Seetharam

2009

Journal of Chemistry

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Alkaloid fractions isolated fromStrychnos potatorumL.f. (Loganiaceae) seed were tested for their antimicrobial properties against some pathogenic gram positive, gram negative and acid-fast bacteria and fungi. These fractions have shown considerable antimicrobial activity against both bacteria and fungi at the tested concentrations (100 & 200 μg/mL). Further, the growth ofProteus vulgaris, taphylococcus aureus, Salmonella typhimurium, Vibrio cholerae, Mycobacterium tuberculosis, Aspergillus nigerandCandida albicanswere significantly inhibited. These findings have confirmed the use of this plant in treating of several microbial infections both in traditional and folk medicine in India.

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Section: Resultssupporting

confidence: 79%

In Vitro Antimicrobial Screening of Alkaloid Fractions from Strychnos potatorum

Mallikharjuna

Seetharam

2009

Journal of Chemistry

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“…Further studies on the structureactivity relationship of 34 different quasidimeric alkaloids (Fig. 2), differing in stereochemistry and substitution pattern, were made by Caron et al (1988). The alkaloids showed similar activities, and minor changes were observed influenced by the C/O ring junction, aromatic substitution, and the oxidation of the C-ring.…”

Section: Terpenoid Indole Alkaloidsmentioning

confidence: 99%

“…Such a substitution leads to an increase of activity for the monomers. A carbomethoxy + Caron et al (1988) 10'-OH-(3c:x,1713 + Caron et al (1988) 10,1O'-d iOMe-(3C:X, 17c:x) + Caron et al (1988) 10, 1O'-diOMc,NMc-(3C:X, 17c:x) + Caron et al (1988) 10 '-OH, 1O-0Me,NMe-(3c:x ,17c:x) + Caron et al (1988) 1O,IO'-diOH,NMe-(3C: X ,17c:x ) + Caron et al (1988) 1O-0H,10'-OMe,NMe-(3c:x,17c:x) + Caron et al (1988) Caron et al (1988) cinchophylline (3c:x,17c:x) + Caron et al (1988Caron et al ( ) cinchophylline (3c:x,1713 + Caron et al (1988) cinchophylline (3J3, 17c:x)…”

Section: Terpenoid Indole Alkaloidsmentioning

confidence: 99%

“…Caron et al (1988) cinchophylline (313,1713) + 32 Caron et al (1988) and derivatives 17,4'-didehydro (3c:x) + Caron et al (1988) 18,19-dihydro (3C: X ,17c:x) + Caron et al (1988Caron et al ( ) 18, 19-dihydro (3c:x, 1713 + Caron et al (1988) (continued ) + Caron et al (1988Caron et al ( ) 18,19-dihydro (313,1713 + Caron et al (1988) 19-0H,18,19-diH (3a,17a) + Caron et al (1988Caron et al ( ) 19-0H,18,19-diH (3a,1713 + 32 Caron et al (1988) 19-0H,18,19-diH OI3,17a) + Caron et al (1988Caron et al ( ) 19-0H,18, 19-diH (313,1713 + Caron et al (1988) Perera et al (1985) 3' -OH-NdeMe-tabernamine + Perera et al (1985) 3' -OH-NdeMe-ervahanine B + Perera et al (1985) Mariee et al (1988) borreveri ne +…”

Section: Terpenoid Indole Alkaloidsmentioning

confidence: 99%

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Antimicrobially Active Alkaloids

Verpoorte¹

1998

Alkaloids

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“…Alkaloids are biologically significant and can act as stimulators, inhibitors and growth terminators [5,6]. They also have anti-microbial and anti-parasitic properties [7-14]. Alkaloids can alter DNA, selectively deform cells and cause locoism.…”

Section: Introductionmentioning

confidence: 99%

BIAdb: A curated database of benzylisoquinoline alkaloids

et al. 2010

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BackgroundBenzylisoquinoline is the structural backbone of many alkaloids with a wide variety of structures including papaverine, noscapine, codeine, morphine, apomorphine, berberine, protopine and tubocurarine. Many benzylisoquinoline alkaloids have been reported to show therapeutic properties and to act as novel medicines. Thus it is important to collect and compile benzylisoquinoline alkaloids in order to explore their usage in medicine.DescriptionWe extract information about benzylisoquinoline alkaloids from various sources like PubChem, KEGG, KNApSAcK and manual curation from literature. This information was processed and compiled in order to create a comprehensive database of benzylisoquinoline alkaloids, called BIAdb. The current version of BIAdb contains information about 846 unique benzylisoquinoline alkaloids, with multiple entries in term of source, function leads to total number of 2504 records. One of the major features of this database is that it provides data about 627 different plant species as a source of benzylisoquinoline and 114 different types of function performed by these compounds. A large number of online tools have been integrated, which facilitate user in exploring full potential of BIAdb. In order to provide additional information, we give external links to other resources/databases. One of the important features of this database is that it is tightly integrated with Drugpedia, which allows managing data in fixed/flexible format.ConclusionsA database of benzylisoquinoline compounds has been created, which provides comprehensive information about benzylisoquinoline alkaloids. This database will be very useful for those who are working in the field of drug discovery based on natural products. This database will also serve researchers working in the field of synthetic biology, as developing medicinally important alkaloids using synthetic process are one of important challenges. This database is available from http://crdd.osdd.net/raghava/biadb/.

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Antimicrobial and Antifungal Activities of Quasi-Dimeric and Related Alkaloids

Abstract: tion of the C-ring of the quasi-dimeric alkaloid decreases the activity. Harman, dihydroharman, and a synthetic bisharman (34) were found to be inactive in this test system at the concentrations tested.

Cited by 28 publications

References 6 publications

In Vitro Antimicrobial Screening of Alkaloid Fractions from Strychnos potatorum

In Vitro Antimicrobial Screening of Alkaloid Fractions from Strychnos potatorum

Antimicrobially Active Alkaloids

BIAdb: A curated database of benzylisoquinoline alkaloids

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